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Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant—a Chinese retrospective cohort study among 148 cases

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Abstract

This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P < 0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.

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References

  1. Ertas IE, Taskin S, Goklu R, Bilgin M, Goc G, Yildirim Y, Ortac F. Long-term oncological and reproductive outcomes of fertilitysparing cytoreductive surgery in females aged 25 years and younger with malignant ovarian germ cell tumors. J Obstet Gynaecol Res 2014; 40(3): 797–805

    Article  PubMed  Google Scholar 

  2. Sieh W, Sundquist K, Sundquist J, Winkleby MA, Crump C. Intrauterine factors and risk of nonepithelial ovarian cancers. Gynecol Oncol 2014; 133(2): 293–297

    Article  PubMed  PubMed Central  Google Scholar 

  3. Nishio S, Ushijima K, Fukui A, Fujiyoshi N, Kawano K, Komai K, Ota S, Fujiyoshi K, Kamura T. Fertility-preserving treatment for patients with malignant germ cell tumors of the ovary. J Obstet Gynaecol Res 2006; 32(4): 416–421

    Article  PubMed  Google Scholar 

  4. Weinberg LE, Lurain JR, Singh DK, Schink JC. Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors. Gynecol Oncol 2011; 121(2): 285–289

    Article  PubMed  Google Scholar 

  5. Bryk S, Farkkila A, Butzow R, Leminen A, Heikinheimo M, Anttonen M, Riska A, Unkila-Kallio L. Clinical characteristics and survival of patients with an adult-type ovarian granulosa cell tumor: a 56-year single-center experience. Int J Gynecol Cancer 2015; 25 (1): 33–41

    Article  PubMed  Google Scholar 

  6. Yesilyurt H, Tokmak A, Guzel AI, Simsek HS, Terzioglu SG, Erkaya S, Gungor T. Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. Asian Pac J Cancer Prev 2014; 15(19): 8447–8450

    Article  PubMed  Google Scholar 

  7. Pectasides D, Pectasides E, Kassanos D. Germ cell tumors of the ovary. Cancer Treat Rev 2008; 34(5): 427–441

    Article  CAS  PubMed  Google Scholar 

  8. Tomao F, Peccatori F, Del Pup L, Franchi D, Zanagnolo V, Panici PB, Colombo N. Special issues in fertility preservation for gynecologic malignancies. Crit Rev Oncol Hematol 2016; 97: 206–219

    Article  PubMed  Google Scholar 

  9. Yang ZJ, Liu ZC, Wei RJ, Li L. An analysis of prognostic factors in patients with ovarian malignant germ cell tumors who are treated with fertility-preserving surgery. Gynecol Obstet Invest 2016; 81(1): 1–9

    Article  CAS  PubMed  Google Scholar 

  10. Slayton RE, Park RC, Silverberg SG, Shingleton H, Creasman WT, Blessing JA. Vincristine, dactinomycin, and cyclophosphamide in the treatment ofmalignant germ cell tumors of the ovary. A Gynecologic Oncology Group Study (a final report). Cancer 1985; 56(2):243–248

    Article  CAS  PubMed  Google Scholar 

  11. Williams SD, Birch R, Einhorn LH, Irwin L, Greco FA, Loehrer PJ. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 1987; 316(23):1435–1440

    Article  CAS  PubMed  Google Scholar 

  12. Low JJ, Ilancheran A, Ng JS. Malignant ovarian germ-cell tumours. Best Pract Res Clin Obstet Gynaecol 2012; 26(3): 347–355

    Article  PubMed  Google Scholar 

  13. Mangili G, Sigismondi C, Lorusso D, Cormio G, Candiani M, Scarfone G, Mascilini F, Gadducci A, Mosconi AM, Scollo P, Cassani C, Pignata S, Ferrandina G. The role of staging and adjuvant chemotherapy in stage I Malignant ovarian germ cell tumors (MOGTs): the MITO-9 study. Ann Oncol 2017; 28(2):333–338

    CAS  PubMed  Google Scholar 

  14. Pedersen-Bjergaard J, Daugaard G, Hansen SW, Philip P, Larsen SO, Rørth M. Increased risk of myelodysplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ-cell tumours. Lancet 1991; 338(8763):359–363

    Article  CAS  PubMed  Google Scholar 

  15. Borovskaya TG, Timina EA, Perova AV, Pakhomova AV, Shchemerova YA, Gol’dberg VE. Pharmacological correction of etoposide ovariotoxicity. Bull Exp Biol Med 2007; 143(5):614–616

    Article  CAS  PubMed  Google Scholar 

  16. Fabbri R, Macciocca M, Vicenti R, Paradisi R, Klinger FG, Pasquinelli G, Spisni E, Seracchioli R, Papi A. Doxorubicin and cisplatin induce apoptosis in ovarian stromal cells obtained from cryopreserved human ovarian tissue. Future Oncol 2016; 12 (14):1699–1711

    Article  CAS  PubMed  Google Scholar 

  17. Swerdlow AJ, Cooke R, Bates A, Cunningham D, Falk SJ, Gilson D, Hancock BW, Harris SJ, Horwich A, Hoskin PJ, Linch DC, Lister A, Lucraft HH, Radford J, Stevens AM, Syndikus I, Williams MV; England and Wales Hodgkin Lymphoma Follow-up Group. Risk of premature menopause after treatment for Hodgkin’s lymphoma. J Natl Cancer Inst 2014; 106(9): dju207

    Article  CAS  PubMed  Google Scholar 

  18. Yoo SC, Kim WY, Yoon JH, Chang SJ, Chang KH, Ryu HS. Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy. Acta Obstet Gynecol Scand 2010; 89(1): 126–130

    Article  PubMed  Google Scholar 

  19. Gadducci A, Lanfredini N, Tana R. Menstrual function and childbearing potential after fertility-sparing surgery and platinumbased chemotherapy for malignant ovarian germ cell tumours. Gynecol Endocrinol 2014; 30(7): 467–471

    Article  CAS  PubMed  Google Scholar 

  20. Cong J, Li P, Zheng L, Tan J. Prevalence and Risk Factors of Infertility at a Rural Site of Northern China. PLoS One 2016; 11(5): e0155563

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by grants from the National Science Foundation of China (No. 81302266) and Hubei Province Health and Family Planning Scientific Research Project (Nos. WJ2015MB003 and WJ2015Q004). The funding sources had no role in the design, analysis, interpretation, or drafting of the manuscript.

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  1. These authors contributed equally to this manuscript.

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China

    Bin Yang, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Yongqun Yuan, Jihui Ai & Kezhen Li

  2. Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University, Hangzhou, 310006, China

    Yan Yu & Xinyu Wang

  3. Department of Gynecologic Oncology, Women’s Hospital, Zhongxiang, 431900, China

    Haiyan Huang

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  1. Bin Yang
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  2. Yan Yu
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  3. Jing Chen
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  4. Yan Zhang
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  5. Ye Yin
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  6. Nan Yu
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  7. Ge Chen
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  8. Shifei Zhu
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  9. Haiyan Huang
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  10. Yongqun Yuan
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  11. Jihui Ai
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  12. Xinyu Wang
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  13. Kezhen Li
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Correspondence to Xinyu Wang or Kezhen Li.

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Yang, B., Yu, Y., Chen, J. et al. Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant—a Chinese retrospective cohort study among 148 cases. Front. Med. 12, 509–517 (2018). https://doi.org/10.1007/s11684-017-0554-3

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  • DOI: https://doi.org/10.1007/s11684-017-0554-3

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