Abstract
As a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction in patients with irritable bowel syndrome (IBS). However, the regional morphological alterations of the thalamus in IBS are not well defined. We acquired structural magnetic resonance data from 34 patients with IBS and 34 demographically similar healthy subjects. Data processing was performed using FMRIB’s Integrated Registration and Segmentation Tool (FIRST). Volumetric analysis and surface-based vertex analysis were both carried out to characterize the morphology of the thalamus and other subcortical structures. Our results suggested that the majority (31 cases) of the patients with IBS had diarrhea-predominant symptoms. Volumetric analysis revealed a larger normalized volume of the right thalamus and left caudate nucleus in patients with IBS than in healthy controls. Surface analysis indicated that the difference arose mainly from the laterodorsal nucleus of the right thalamus, and the body of the left caudate nucleus. In addition, patients with IBS had different hemispheric asymmetries of the thalamus (rightward) and caudate nucleus (leftward) from controls (leftward for the thalamus and rightward for the caudate nucleus). In general, our results indicated that patients with diarrhea-predominant IBS had enlarged thalamus and caudate nucleus volumes, as well as altered hemispheric asymmetries of these two structures, compared with healthy controls. The neuroimaging evidence of these structural alterations helps clarify the underlying pathophysiology of diarrhea-predominant IBS.
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Acknowledgements
The authors gratefully acknowledge the financial support provided by China Scholarship Council (No. 201806285075). The study was funded by the Natural Science Foundation of Shaanxi Province (2018SF-135), National Natural Science Foundation of China (81501455), as well as Xi’an Science and Technology Bureau (2016048SF/YX04(3)).
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Mao, C.P., Chen, F.R., Sun, H.H. et al. Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study. Brain Imaging and Behavior 14, 2302–2310 (2020). https://doi.org/10.1007/s11682-019-00181-w
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DOI: https://doi.org/10.1007/s11682-019-00181-w