Skip to main content

Advertisement

Log in

Focus on Effects of Chinese Medicine on Improving Anxiety-Depression and Quality of Life of Patients with Primary Sjögren’s Syndrome

  • Feature Article
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease with a long duration of illness, for which there is no cure. Patients often suffer from anxiety and depression due to various reasons, exhibiting a decline in their quality of life. Chinese medicine (CM) has certain advantages in the treatment of pSS, which not only helps relieve clinical symptoms and improve treatment outcomes, but also reduces anxiety and depression and improves the quality of life. Therefore, CM should be considered as early as possible given its effectiveness and synergistic effects in treating pSS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Zhao Y, Li Y, Wang L, Li XF, Huang CB, Wang GC, et al. Primary Sjogren’s syndrome in Han Chinese clinical and immunological characteristics of 483 patients. Medicine 2015;94:1–8.

    CAS  Google Scholar 

  2. Qin BD, Wang JQ, Yang ZX, Yang M, Ma N, Huang FL, et al. Epidemiology of primary Sjögren’s syndrome: a systematic review and meta-analysis. Ann Rheum Dis 2015;74:1983–1989.

    Article  CAS  Google Scholar 

  3. Chinese Rheumatology Association. Guidelines for the diagnosis and management of Sjögren’s syndrome. Chin J Rheumatol (Chin) 2010;14:766–768.

    Google Scholar 

  4. Thorne I, Sutcliffe N. Sjögren’s syndrome. Br J Hosp Med (Lond) 2017;78:438–442.

    Article  Google Scholar 

  5. Meijer JM, Meiners PM, Huddleston Slater JJR, Spijkervet FKL, Kallenberg CGM, Vissink A, et al. Health-related quality of life, employment and disability in patients with Sjogren’s syndrome. Rheumatology (Oxford) 2009;48:1077–1082.

    Article  Google Scholar 

  6. Ramos-Casals M, Brito-Zerón P, Sisó-Almirall A, Bosch X. Primary Sjögren’s syndrome. BMJ 2012;344:e3821.

    Article  Google Scholar 

  7. Ding Y, Han JM, Han M, Liu G, Li W, Xiao Y, et al. Meta analysis of the therapeutic effects on xerostomia treated with Chinese herbal medicine. World J Integr Tradit West Med (Chin) 2017;12:1213–1220.

    Google Scholar 

  8. Luo H, Li XX, Liu JP. Chinese herbal medicine in treating Primary Sjögren’s syndrome: a systematic review of randomized trials. Evid Based Complement Alernat Med 2012;2012:640658.

    Google Scholar 

  9. Chou A, Gonzales JA, Daniels TE, Criswell LA, Shiboski SC, Shiboski CH. Health-related quality of life and depression among participants in the Sjögren’s International Collaborative Clinical Alliance registry. RMD Open 2017;3:e000495.

    Article  Google Scholar 

  10. Cui BB, Qing PY, Liu Y. Neuropsychiatric syndromes in patients with primary Sjogren’s syndrome: anxiety and relative factors. Sichuan Med (Chin) 2012;33:707–708.

    Google Scholar 

  11. Barbara S, Simon JB, Philip CF, Frederick BV, Nandita SJ, Bowman J, et al. Primary Sjogren’s syndrome: health experiences and predictors of health quality among patients in the United States. Health Qual Life Outcomes 2009;7:46–54.

    Article  Google Scholar 

  12. Westhoff G, Dorner T, Zink A. Fatigue and depression predict physician visits and work disability in women with primary Sjogren’s syndrome: results from a cohort study. Rheumatology 2012;51:262–269.

    Article  Google Scholar 

  13. Lendrem D, Mitchell S, McMeekin P, Gompels L, Hackett K, Bowman S, et al. Health-related utility values of patients with primary Sjogren’s syndrome and its predictors. Ann Rheum Dis 2014;73:1362–1368.

    Article  Google Scholar 

  14. Xu ZR, Chen F, Jiang FG, Yan CZ. Evaluation of quality of life in dry eye patients with Sjogren’s syndrome. Int J Ophthalmol (Chin) 2010;10:280–282.

    Google Scholar 

  15. Yang J, Liu J, Zhang JS, Wang SH. Quality of life in patients with Sjogren’s syndrome and the influencing factors. Clin J Tradit Chin Med (Chin) 2011;23:534–536.

    Google Scholar 

  16. Liu ZX, Hao WX. Evaluation of life quality, anxiety and depression on 309 patients with primary Sjogren’s syndrome. J Med Res (Chin) 2016;45:101–103.

    Google Scholar 

  17. Wu R, Zhang J, Zhou Q, Liu J, Zhu J. Analysis on quality of life and mental state of patients with primary Sjogren’s syndrome. Gansu Med J (Chin) 2016;35:911–913.

    Google Scholar 

  18. Xie BH, Peng Y, Chen Y, Zhang S, Wu XD, Zhang Z, et al. Expression of P2X7 receptors on peripheral blood mononuclear cells in patients with primary Sjogren’s syndrome and its correlation with anxiety and depression. Chin J Allergy Clin Immunol (Chin) 2013;7:217–223.

    CAS  Google Scholar 

  19. Baturone R, Soto MJ, Márquez M, Macías I, Montes de Oca M, Medina F, et al. Health-related quality of life in patients with primary Sjogren’s syndrome: relationship with serum levels of proinflammatory cytokines. Scand J Rheumatol 2009;38:386–389.

    Article  CAS  Google Scholar 

  20. Liu J, Wan L, Liu L, Feng YX, Cheng YY, Huang CB, et al. Analysis on SF-36 integral changes of life quality of 440 cases rheumatic patients and the influencing factors. Rheumat Arthrit (Chin) 2012;1:19–23.

    Google Scholar 

  21. Enger TB, Palm O, Garen T, Sandvik L, Jensen JL. Oral distress in primary Sjogren’s syndrome: implications for health-related quality of life. Eur J Oral Sei 2011;119:474–480.

    Article  Google Scholar 

  22. Wang Q, Li TY, Chen YL, Wu GL. Exploration into traditional Chinese medicine syndrome distribution laws of Sjögren’s syndrome based on syndrome elements. West J Tradit Chin Med (Chin) 2018;31:81–85.

    Google Scholar 

  23. Wu GL, Li TY, Fan YS, Yu GY, Chen J. Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjögren’s syndrome. Chin J Integr Med 2013;19:696–700.

    Article  Google Scholar 

  24. Jiang Y, Zhang Q. The effects of tripterygium glycosides combined with total glucosides of paeony with tripterygium glycosides on the serum Th17/Treg balance and immune functions in Sjogren’s syndrome patients. Guizhou Med J (Chin) 2018;42:1446–1447.

    Google Scholar 

  25. Jin GL. Experimental research on hot indexes of Chinese medicine treatment on Sjogren’s syndrome. Lishizhen Med Mater Med Res (Chin) 2011;22:948–949.

    CAS  Google Scholar 

  26. Wu GL, Lu HF, Chen YL, Wang Q, Cao H, Li TY. Changes of intestinal microecology in patients with primary Sjogren’s syndrome after therapy of Yangyin Yiqi Huoxue Recipe. Chin J Integr Med 2019;25:654–662.

    Article  CAS  Google Scholar 

  27. Wu GL, Wu NY, Li TY, Fan YS, Yu GY, Lu WW. Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the reproductive endocrine and immune networks in patients with primary Sjogren’s syndrome. Chin J Integr Med 2015;21:778–783.

    Article  Google Scholar 

  28. Da MM, Ji W. Treatment of Sjogren syndrome from Liver qi stagnation and deficiency of yin. Jilin J Tradit Chin Med (Chin) 2016;36:979–982.

    Google Scholar 

  29. WANG Y. My opinion on TCM differentiation and treatment of sjogren’s syndrome. Rheumat Arthritis (Chin) 2012;1:15–7.

    CAS  Google Scholar 

  30. Shi J, Qian X. Study on the differentiation and treatment of primary Sjogren’s syndrome complicated with anxiety based on the theory of body fluids and blood have the same origin. Jiangsu J Tradit Chin Med (Chin) 2016;48:42–43.

    Google Scholar 

  31. Gu JH, Chen XJ. Treatment of Sjogren’s syndrome based on syndrome differentiation of Liver. J Tradit Chin Med (Chin) 2011;52:292–294

    Google Scholar 

  32. Zhong Z, Wang XC. The treatment of 32 patients with primary Sjogren’s syndrome complicated with anxiety with self-designed Yangwenwugan prescription combined with hydroxychloroquine. Zhejiang J Tradit Chin Med (Chin) 2019;54:281.

    Google Scholar 

  33. Chen YL, Wu GL. Research status of Chinese medicine in improving anxiety and depression and life quality of Sjogren’s syndrome. Chin J Tradit Chin Med Pharm (Chin) 2019;34:5808–5811.

    Google Scholar 

  34. Ren LH. Self-designed Ziyin Jieyu Decoction combined with Western medicine in the treatment of 50 cases of anxiety and depression in Sjogren’s syndrome patients. Zhejiang J Tradit Chin Med (Chin) 2016;51:205.

    Google Scholar 

  35. Wang GZ, Liu J, Fan HX, Wang F. Effects of Xinfeng Capsule on the life quality of 20 cases with Sjogren syndrome. Rheumat Arthritis (Chin) 2014;3:9–13.

    Google Scholar 

  36. Wu GL, Li TY, Fan YS, Yu GY. Therapeutic effect of Chinese herbal medicine for Yiqi Yangyin Quyu on the level of osteopontin in peripheral blood and quality of life in patients with primary Sjogren’s syndrome. Chin J Integr Med 2011;17:710–714.

    Article  Google Scholar 

  37. Wei N, Fan HR, Ding MH, Li SQ, Zhu YL. Influence of Chinese medicine chronic disease management on disease control and quality of life in patients with Sjogren’s syndrome. J Tradit Chin Med (Chin) 2017;58:316–320.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guo-lin Wu.

Additional information

Supported by National Natural Science Foundation of China (No. 81473604) and Natural Science Foundation of Zhejiang Province, China (No. LY19H270013)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, Gl., Li, Ty. Focus on Effects of Chinese Medicine on Improving Anxiety-Depression and Quality of Life of Patients with Primary Sjögren’s Syndrome. Chin. J. Integr. Med. 26, 486–489 (2020). https://doi.org/10.1007/s11655-020-3473-0

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11655-020-3473-0

Keywords

Navigation