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Effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on reproductive endocrine activity and immune functions in patients with primary Sjogren’s syndrome

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Abstract

Objective

To investigate the effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on the reproductive endocrine-immune network and its mechanisms in patients with primary Sjogren's syndrome (pSS).

Methods

Seventy pSS patients were randomly assigned to two groups using a randomized digital table: the integrative therapy group (36 cases) and the control group (34 cases). Thirty healthy subjects were taken as a normal group. The control group was treated with hydroxychloroquine sulfate tablets alone, and the integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets. The treatment course was 6 months for both groups. Before and after treatment, serum estradiol (E2), testosterone (T), luteinizing hormone (LH), prolactin (PRL) by radioimmunoassay and immunoglobulin (IgG) by immunodiffusion, erythrocyte sedimentation rate (ESR) by Westergren, interferon-γ (IFN-γ) and interleukin-4 (IL-4) by enzyme linked immunosorbent assay were determined.

Results

E2 and T levels in all patients were lower than those of normal subjects before treatment (P<0.05) and were increased significantly after 6-month treatment (P<0.05). ESR, FSH, LH, IgG, IFN - γ, IL - 4 and ratios of E2/T, and IFN -γ/IL in the patients were higher than those of normal subjects before the treatments (P<0.05), and were reduced significantly after the treatments (P<0.05). The T and IFN - γ levels and E2/T ratio in the patients treated with integrative therapy were reduced significantly compared with the control group (P<0.05). However, the PRL levels before and after treatment were not significantly changed in the two groups (P>0.05). The ratios of E2/T and IFN -γ/IL-4, and levels of IgG and ESR were positively correlated before and after treatment (P<0.05).

Conclusions

The ratios of E2/T and IFN -γ/IL-4 might be used as indicators of pSS activity. Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with Western medicine could improve the therapeutic effect by regulating the reproductive endocrine-immune network in pSS patients.

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Authors and Affiliations

  1. The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China

    Guo-lin Wu  (吴国琳), Na-yuan Wu  (吴娜媛), Guo-you Yu  (余国友) & Wen-wen Lu  (卢雯雯)

  2. Zhejiang University of Chinese Medicine, Hangzhou, 310053, China

    Tian-yi Li  (李天一) & Yong-sheng Fan  (范永升)

Authors
  1. Guo-lin Wu  (吴国琳)
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  2. Na-yuan Wu  (吴娜媛)
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  3. Tian-yi Li  (李天一)
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  4. Yong-sheng Fan  (范永升)
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  5. Guo-you Yu  (余国友)
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  6. Wen-wen Lu  (卢雯雯)
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Corresponding author

Correspondence to Tian-yi Li  (李天一).

Additional information

Supported by the National Natural Science Foundation of China (No. 81473604)

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Wu, Gl., Wu, Ny., Li, Ty. et al. Effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on reproductive endocrine activity and immune functions in patients with primary Sjogren’s syndrome. Chin. J. Integr. Med. 21, 778–783 (2015). https://doi.org/10.1007/s11655-015-2323-y

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  • DOI: https://doi.org/10.1007/s11655-015-2323-y

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