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Association Between Juxtapapillary Duodenal Diverticula and Risk of Choledocholithiasis: a Systematic Review and Meta-analysis

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background/Objectives

Studies have suggested that the presence of juxtapapillary duodenal diverticula (JDD) could be a predisposing factor for choledocholithiasis. This systematic review and meta-analysis was conducted with the aims to summarize all available evidence to better characterize the risk.

Methods

A literature search was performed using MEDLINE and EMBASE database from inception to January 2018. Cross-sectional studies that reported odd ratios (OR) comparing the risk of choledocholithiasis among individuals with JDD versus individuals without JDD were included. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Results

Of 527 retrieved articles, 11 studies met our eligibility criteria and were included in analysis. We found a significant association between the presence of JDD and choledocholithiasis with the pooled OR of 2.30 (95% CI, 1.84–2.86). The statistical heterogeneity was moderate with an I2 of 60%.

Conclusions

A significantly increased risk of choledocholithiasis among individuals with JDD was observed in this study.

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Authors and Affiliations

  1. Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA

    Karn Wijarnpreecha

  2. Division of Gastroenterology and Hepatology, Mayo Clinic, Mayo Clinic College of Medicine, Jacksonville, FL, USA

    Karn Wijarnpreecha, Surakit Pungpapong & Frank J. Lukens

  3. Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    Panadeekarn Panjawatanan

  4. Department of Gastroenterology & Hepatology, University of Nebraska Medical Center, Omaha, NE, USA

    Wuttiporn Manatsathit

  5. Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, MS, USA

    Wisit Cheungpasitporn

  6. Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand

    Patompong Ungprasert

Authors
  1. Karn Wijarnpreecha
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  2. Panadeekarn Panjawatanan
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  3. Wuttiporn Manatsathit
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  4. Wisit Cheungpasitporn
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  5. Surakit Pungpapong
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  6. Frank J. Lukens
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  7. Patompong Ungprasert
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All authors had access to the data and a role in writing the manuscript.

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Correspondence to Patompong Ungprasert.

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The authors declare that they have no conflicts of interest.

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Wijarnpreecha, K., Panjawatanan, P., Manatsathit, W. et al. Association Between Juxtapapillary Duodenal Diverticula and Risk of Choledocholithiasis: a Systematic Review and Meta-analysis. J Gastrointest Surg 22, 2167–2176 (2018). https://doi.org/10.1007/s11605-018-3865-z

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  • DOI: https://doi.org/10.1007/s11605-018-3865-z

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