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One shot of carbon-ion radiotherapy cured a 6-cm chemo-resistant metastatic liver tumor: a case of breast cancer

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Abstract

The standard treatment for metastatic liver tumor from breast cancer is systemic medical treatment, and there is controversy regarding the value of local treatment. However, there are some exceptional cases that do benefit from local therapy. We describe the case of a 54-year-old woman with systemic therapy-resistant liver metastasis from breast cancer successfully treated with a single shot of 36-GyE carbon-ion radiotherapy and surviving more than 8 years without local recurrence. This case represents a good example of the usefulness and safety of carbon-ion radiotherapy, and who might benefit from local therapy.

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References

  1. Makita M, Sakai T, Ogiya A, Kitagawa D, Morizono H, Miyagi Y, Iijima K, Iwase T. Optimal surveillance for postoperative metastasis in breast cancer patients. Breast Cancer. 2014. doi:10.1007/s12282-014-0571-x.

    Google Scholar 

  2. Milano MT, et al. Descriptive analysis of oligometastatic lesions treated with curative-intent stereotactic body radiotherapy. Int J Radiat Oncol Biol Physc. 2008;72:1516–22.

    Article  Google Scholar 

  3. Milano MT, et al. Oligometastases treated with stereotactic body radiotherapy: long-term follow-up of prospective study. Int J Radiat Oncol Biol Phys. 2012;83:878–86.

    Article  PubMed  Google Scholar 

  4. Atalay G, Biganzoli L, Renard F, Paridaens R, Cufer T, Coleman R, et al. Clinical outcome of breast cancer patients with liver metastases alone in the anthracycline-taxane era: a retrospective analysis of two prospective, randomised metastatic breast cancer trials. Eur J Cancer. 2003;39:2439–49.

    Article  CAS  PubMed  Google Scholar 

  5. Elsberger B, Roxburgh CS, Horgan PG. Is there a role for surgical resections of hepatic breast cancer metastases? Hepatogastroenterology. 2014;61:181–6.

    PubMed  Google Scholar 

  6. Habermehl D, Herfarth KK, Bermejo JL, Hof H, Rieken S, Kuhn S, et al. Single-dose radiosurgical treatment for hepatic metastases–therapeutic outcome of 138 treated lesions from a single institution. Radiat Oncol. 2013;8:175.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Yuan ZY, Meng MB, Liu CL, Wang HH, Jiang C, Song YC, et al. Stereotactic body radiation therapy using the CyberKnife® system for patients with liver metastases. Onco Targets Ther. 2014;12(7):915–23.

    Article  Google Scholar 

  8. Kümler I, Parner VK, Tuxen MK, Skjoldbye B, Bergenfeldt M, Nelausen KM, et al. Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer. Radiol Med. 2015;120:536–41.

    Article  PubMed  Google Scholar 

  9. Kamada T, Tsujii H, Blakely EA, Debus J, De Neve W, Durante M, et al. Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience. Lancet Oncol. 2015;16:e93–100.

    Article  PubMed  Google Scholar 

  10. Akamatsu H, Karasawa K, Omatsu T, Isobe Y, Ogata R, Koba Y. First experience of carbon-ion radiotherapy for early breast cancer. Jpn J Radiol. 2014;32:288–95.

    Article  CAS  PubMed  Google Scholar 

  11. Skinner HD, Hong TS, Krishnan S. Charged-particle therapy for hepatocellular carcinoma. Semin Radiat Oncol. 2011;21:278–86.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Imada H, Kato H, Yasuda S, Yamada S, Yanagi T, Kishimoto R, et al. Comparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis. Radiother Oncol. 2010;96:231–5.

    Article  PubMed  Google Scholar 

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Correspondence to Mayumi Harada.

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Harada, M., Karasawa, K., Yasuda, S. et al. One shot of carbon-ion radiotherapy cured a 6-cm chemo-resistant metastatic liver tumor: a case of breast cancer. Jpn J Radiol 33, 598–602 (2015). https://doi.org/10.1007/s11604-015-0462-x

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  • DOI: https://doi.org/10.1007/s11604-015-0462-x

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