Abstract
Clinical trials of carbon-ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) were conducted at the National Institute of Radiological Sciences (NIRS) in Japan between April 1995 and August 2005. In four clinical studies, we tried to determine the optimal dose and to shorten the treatment duration with five different fractionation schedules, using 15, 12, 8, 4, and 2 fractionations. There have been no treatment-related deaths and no severe adverse events. As a result of these studies, the duration of treatment could be reduced from 5 weeks to 2 days. Two-fraction therapy is currently ongoing under the license of Highly Advanced Medical Technology. Because of the low toxicity and good local control rate, C-ion RT is a promising radical and minimally invasive therapeutic option for HCC.
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Yasuda, S. (2014). Hepatocellular Carcinoma. In: Tsujii, H., Kamada, T., Shirai, T., Noda, K., Tsuji, H., Karasawa, K. (eds) Carbon-Ion Radiotherapy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54457-9_25
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DOI: https://doi.org/10.1007/978-4-431-54457-9_25
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