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Change of iodine load and thyroid homeostasis induced by ammonium perchlorate in rats

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Summary

Ammonium perchlorate (AP), mainly used as solid propellants, was reported to interfere with homeostasis via competitive inhibition of iodide uptake. However, detailed mechanisms remain to be elucidated. In this study, AP was administered at 0, 130, 260 and 520 mg/kg every day to 24 male SD rats for 13 weeks. The concentrations of iodine in urine, serum thyroid hormones levels, total iodine, relative iodine and total protein, and malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity in thyroid tissues were measured, respectively. Our results showed that high-dose perchlorate induced a significant increase in urinary iodine and serum thyroid stimulating hormone (TSH), with a decrease of total iodine and relative iodine content. Meanwhile, free thyroxine (FT4) was decreased and CAT activity was remarkably increased. Particularly, the CAT activity was increased in a dose-dependent manner. These results suggested that CAT might be enhanced to promote the synthesis of iodine, resulting in elevated urinary iodine level. Furthermore, these findings suggested that iodine in the urine and CAT activity in the thyroid might be used as biomarkers for exposure to AP, associated with thyroid hormone indicators such as TSH, FT4.

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Authors and Affiliations

  1. Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China

    Hong-xia Chen  (陈红霞)

  2. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Hong-xia Chen  (陈红霞), Miao-hong Ding  (丁淼鸿), Qin Liu  (刘 琴) & Kai-liang Peng  (彭开良)

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  1. Hong-xia Chen  (陈红霞)
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  2. Miao-hong Ding  (丁淼鸿)
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  3. Qin Liu  (刘 琴)
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  4. Kai-liang Peng  (彭开良)
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Correspondence to Kai-liang Peng  (彭开良).

Additional information

This project was supported by the National Natural Science Foundation of China (No. 30972452).

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Chen, Hx., Ding, Mh., Liu, Q. et al. Change of iodine load and thyroid homeostasis induced by ammonium perchlorate in rats. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 34, 672–678 (2014). https://doi.org/10.1007/s11596-014-1335-8

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  • DOI: https://doi.org/10.1007/s11596-014-1335-8

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