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TiO2 modified carbon paste sensor for voltammetric analysis and chemometric optimization approach of amlodipine in commercial formulation

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Abstract

A new square wave adsorptive stripping voltammetric (SWAdSV) approach using experimental design and optimization methodology was developed for the quantitative estimation of amlodipine (AMP) in pharmaceutical tablets. To this end, a new carbon paste electrode (CPE) system was fabricated using titanium dioxide (TiO2) nanoparticles to get very well-defined oxidation peak current of AMP under the optimized conditions. Optimal electrochemical conditions for three factor variables, the pH, the accumulation potential, and the accumulation time, were obtained by applying a 33 full factorial design and optimization technique to the oxidation of AMP on the TiO2 modified CPE (TiO2-CPE) system. The numerical values of the optimal voltammetric parameters consisting of the pH, accumulation potential, and accumulation time were found to be 5.69, 562.30 mV, and 64.30 s for the analysis of AMP in samples, respectively. The newly developed voltammetric method for the determination of AMP offers a linear relationship between the peak current and concentration in the range of 1.0 × 10−8 − 1.0 × 10−6 M with the correlation coefficient (r = 0.9990) and the detection limit (LOD = 2.97 × 10−9 M). The lifetime of prepared electrode was also tested, and the current intensity of AMP was nearly stable at least 2 months by using TiO2-CPE. The validity of the method was tested by analyzing standard samples containing the analyzed compound. Under optimized and validated experimental conditions, the proposed method was successfully applied for the quantitative analysis of AMP in commercial tablets.

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References

  1. Steffen HM (1999) Amlodipine—a third generation dihydropyridine calcium antagonist. J Clin Basic Cardiol 2:45–52

    CAS  Google Scholar 

  2. Matalka K, El-Thaher T, Saleem M, Arafat T, Jehanli A, Badwan A (2001) Enzyme linked immunosorbent assay for determination of amlodipine in plasma. J Clin Lab Anal 15:47–53

    Article  CAS  Google Scholar 

  3. Li J, Li Y, Zhang W, Chen Z, Fan G (2013) Glucose-β-CD interaction assisted ACN field-amplified sample stacking in CZE for determination of trace amlodipine in beagle dog plasma. J Sep Sci 36:1817–1825

    Article  CAS  Google Scholar 

  4. Darwisha HW, Bakheita AH, Darwisha IA (2012) New spectrofluorimetric methods for the simultaneous determination of olmesartan medoxamil and amlodipine besylate in their combined tablets. Dig J Nanomater Bios 7:1599–1608

    Google Scholar 

  5. Ensafi AA, Bahrami H, Rezaei B, Maleh H-K (2013) Application of ionic liquid TiO2 nanoparticle modified carbon paste electrode for the voltammetric determination of benserazide in biological samples. Mater Sci Eng C 33:831–835

    Article  CAS  Google Scholar 

  6. Tashkhourian J, Nami Ana SF, Hashemnia S, Hormozi-Nezhad MR (2013) Construction of a modified carbon paste electrode based on TiO2 nanoparticles for the determination of gallic acid. J Solid State Electrochem 17:157–165

    Article  CAS  Google Scholar 

  7. Shrivastava R, Saxena S, Satsangee SP, Jain R (2015) Graphene/TiO2/polyaniline nanocomposite based sensor for the electrochemical investigation aripiprazole in pharmaceutical formulation. Ionics 21:2039–2049

    Article  CAS  Google Scholar 

  8. Demir E, Inam R, Ozkan SA, Uslu B (2014) Electrochemical behavior of tadalafil on TiO2 nanoparticles–MWCNT composite paste electrode and its determination in pharmaceutical dosage forms and human serum samples using adsorptive stripping square wave voltammetry. J Solid State Electrochem 18:2709–2720

    Article  CAS  Google Scholar 

  9. Gizawy SM, Bebawy LI, Abdelmageed OH, Omar MA, Deryea SM, Abdel-Megied AM (2013) High performance liquid chromatography, TLC-densitometry, and first-derivative spectrophotometry for simultaneous determination of amlodipine and perindopril in bulk powder and its tablets. J Liq Chrom Relat Technol 36:1323–1339

    CAS  Google Scholar 

  10. Kamble AY, Mahadik MV, Khatal LD, Dhaneshwar SR (2010) Validated HPLC and HPTLC method for simultaneous quantitation of amlodipine besylate and olmesartan medoxomil in bulk drug and formulation. Anal Lett 43:251–258

    Article  CAS  Google Scholar 

  11. Maurer HH, Arlt JW (1999) Screening procedure for detection of dihydropyridine calcium channel blocker metabolites in urine as part of a systematic toxicological analysis procedure for acidic compounds by gas chromatography-mass spectrometry after extractive methylation. J Anal Toxicol 23:73–80

    Article  CAS  Google Scholar 

  12. Suchanova B, Kostiainen R, Ketola RA (2008) Characterization of the in vitro metabolic profile of amlodipine in rat using liquid chromatography–mass spectrometry. Eur J Pharm Sci 33:91–99

    Article  CAS  Google Scholar 

  13. Singh S, Patel K, Agrawal VK, Chaturvedi S (2012) Simultaneous estimation of S(−) amlodipine besylate hemipentahydrate and losartan potassium in combined dosage form by using uv˗spectroscopy. Der Pharm Lett 4:897–905

    CAS  Google Scholar 

  14. Inglot TW, Gumıenıczek A, Komsta Ł, Zwıązek R (2013) Densitometry, video˗scanning and capillary electrophoresis for determination of valsartan and amlodipine in a combined dosage form: a comparative study. Acta Chromatogr 25:47–58

    Article  CAS  Google Scholar 

  15. Wang J (2000) Analytical electrochemistry. Wiley VCH, New York

    Book  Google Scholar 

  16. Erden S, Durmus Z, Kılıç E (2011) Simultaneous determination of antimony and lead in gunshot residue by cathodic adsorptive stripping voltammetric methods. Electroanalysis 23:1967–1974

    Article  CAS  Google Scholar 

  17. Gazzy AAK (2004) Determination of amlodipine besylate by adsorptive square-wave anodic stripping voltammetry on glassy carbon electrode in tablets and biological fluids. Talanta 62:575–582

    Article  Google Scholar 

  18. Sikkander ARM, Vedhi C, Manisankar P (2011) Electrochemical stripping studies of amlodipine using Mwcnt modified glassy carbon electrode. Chem Mater Res 1:1–7

    Google Scholar 

  19. Stoiljković Z, Avramov Ivić ML, Petrović SD, Mijin D, Stevanović SI, Lačnjevac U, Marinković AD (2012) Voltammetric and square-wave anodic stripping determination of amlodipine besylate on gold electrode. Int J Electrochem Sci 7:2288–2303

    Google Scholar 

  20. Altiokka G, Dogrukol-Ak D, Tunçel M, Aboul-Enein HY (2002) Determination of amlodipine in pharmaceutical formulations by differential-pulse voltammetry with a glassy carbon electrode. Arch Pharm Pharm Med Chem 2:104–108

    Article  Google Scholar 

  21. Topal BD, Bozal B, Demircigil BT, Uslu B, Ozkan SA (2009) Electroanalytical studies and simultaneous determination of amlodipine besylate and atorvastatine calcium in binary mixtures using first derivative of the ratio-voltammetric methods. Electroanalysis 21:2427–2439

    Google Scholar 

  22. Goyal RN, Bishnoi S (2010) Voltammetric determination of amlodipine besylate in human urine and pharmaceuticals. Bioelectrochemistry 79:234–240

    Article  CAS  Google Scholar 

  23. Uslu B, Ozkan SA (2007) Electroanalytical application of carbon based electrodes to the pharmaceuticals. Anal Lett 40:817–853

    Article  CAS  Google Scholar 

  24. Güzel R, Ekşi H, Dinç E, Solak AO (2013) New voltammetric approach to the quantitative estimation of sildenafil citrate in tablets using disposable pencil graphite electrode. J Electrochem Soc 160:B119–B124

    Article  Google Scholar 

  25. Szroeder P, Tsierkezos NG, Walczyk M, Strupiński W, Górska-Pukownik A, Strzelecki J, Wiwatowski K, Scharff P, Ritter U (2014) Insights into electrocatalytic activity of epitaxial graphene on SiC from cyclic voltammetry and ac impedance spectroscopy. J Solid State Electrochem 18:2555–2562

    Article  CAS  Google Scholar 

  26. Bradea O, Banica F (2010) Differential pulse adsorption voltammetry for determination of amlodipine besylate at carbon paste electrode in pharmaceutical preparations. Fascicula Chim 17:18–23

    CAS  Google Scholar 

  27. Mohammadi A, Moghaddam AB, Eilkhanizadeh K, Alikhani E, Mozaffari S, Yavari T (2013) Electro-oxidation and simultaneous determination of amlodipine and atorvastatin in commercial tablets using carbon nanotube modified electrode. Micro Nano Lett 8:413–417

    Article  CAS  Google Scholar 

  28. Mansano GR, Eisele APP, Dall’Antonia LH, Afonso S, Sartori ER (2015) Electroanalytical application of a boron˗doped diamond electrode: improving the simultaneous voltammetric determination of amlodipine and valsartan in urine and combined dosage forms. J Electroanal Chem 738:188–194

    Article  CAS  Google Scholar 

  29. Švorc L, Cinková K, Sochr J, Vojs M, Michniak P, Marton M (2014) Sensitive electrochemical determination of amlodipine in pharmaceutical tablets and human urine using a boron-doped diamond electrode. J Electroanal Chem 728:86–93

    Article  Google Scholar 

  30. Erden PE, Tasdemir IH, Kacar C, Kilic E (2014) Simultaneous determination of valsartan and amlodipine besylate in human serum and pharmaceutical dosage forms by voltammetry. Int J Electrochem Sci 9:2208–2220

    Google Scholar 

  31. Valezi CF, Duarte EH, Mansano GR, Dall’Antonia LH, Tarley CRT, Sartori ER (2014) An improved method for simultaneous square-wave voltammetric determination of amlodipine and enalapril at multi-walled carbon nanotubes paste electrode based on effect of cationic surfactant. Sensors Actuators B 205:234–243

    Article  CAS  Google Scholar 

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Acknowledgments

This research has been supported by the Ankara University Scientific Research projects Coordination Unit, Project Nos. 13J4240009 and 2005-07-05-094.

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Authors and Affiliations

  1. General Directorate of Mineral Research and Exploration, 06800, Ankara, Turkey

    Sevcan Erden

  2. Faculty of Science, Department of Chemistry, Ankara University, 06100, Ankara, Turkey

    Dilek Eskiköy Bayraktepe & Zehra Yazan

  3. Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, 06100, Ankara, Turkey

    Erdal Dinç

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  1. Sevcan Erden
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  2. Dilek Eskiköy Bayraktepe
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  3. Zehra Yazan
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  4. Erdal Dinç
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Correspondence to Sevcan Erden.

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Erden, S., Eskiköy Bayraktepe, D., Yazan, Z. et al. TiO2 modified carbon paste sensor for voltammetric analysis and chemometric optimization approach of amlodipine in commercial formulation. Ionics 22, 1231–1240 (2016). https://doi.org/10.1007/s11581-015-1629-2

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  • DOI: https://doi.org/10.1007/s11581-015-1629-2

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