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Graphene/TiO2/polyaniline nanocomposite based sensor for the electrochemical investigation of aripiprazole in pharmaceutical formulation

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Abstract

A highly sensitive and selective sensor is fabricated based on graphene/titanium dioxide/polyaniline modified glassy carbon electrode (GRP/TiO2/PANI/GCE). It is demonstrated that this sensor can be used for determination of a pharmaceutically important compound aripiprazole (ARP) using square wave voltammetry and cyclic voltammetry (SWV & CV). Scanning electron microscope (SEM) was used to investigate the assembly process of the nanocomposite modifier. The electrochemical investigation of ARP at (GRP/TiO2/PANI/GCE) was found to be the function of pH of the supporting electrolyte, and variation in scan rate and concentration. Electro-oxidation of ARP showed irreversible and adsorption-controlled behaviour at GRP/TiO2/PANI/GCE. Charge transfer coefficient and number of electrons and protons involved in the electrode mechanism were calculated. SWV of different concentrations of ARP showed a linear dynamic range from 5 to 40 ng/mL with the detection limit of 0.99 ng/mL. The analytical performance of this sensor has been evaluated for the detection of ARP in pharmaceutical formulation with satisfactory results.

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Acknowledgments

Authors acknowledge the central facility, department of Indian Institute of Technology, New Delhi, India, for carrying out SEM characterization. They are thankful to the UGC-BSR for the fellowship to two of the authors (Ratnanjali Shrivastava and Sachin Saxena).

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Authors and Affiliations

  1. USIC, Dayalbagh Educational Institute, Dayalbagh, Agra, 282005, India

    Ratnanjali Shrivastava, Sachin Saxena & Soami P. Satsangee

  2. School of Studies in Chemistry, Jiwaji University, Gwalior, 474011, India

    Rajeev Jain

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  1. Ratnanjali Shrivastava
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  2. Sachin Saxena
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  3. Soami P. Satsangee
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  4. Rajeev Jain
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Correspondence to Soami P. Satsangee.

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Shrivastava, R., Saxena, S., Satsangee, S.P. et al. Graphene/TiO2/polyaniline nanocomposite based sensor for the electrochemical investigation of aripiprazole in pharmaceutical formulation. Ionics 21, 2039–2049 (2015). https://doi.org/10.1007/s11581-014-1353-3

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  • DOI: https://doi.org/10.1007/s11581-014-1353-3

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