Abstract
Iron deficiency is a serious global issue, particularly in developing countries. Individuals are suffering from iron deficiency due to monotonous consumption of cereal based diets, which are unable to provide adequate amounts of iron. The majority of these people cannot afford a diversified diet, iron supplements and iron fortified food products. The development of iron biofortified potatoes could provide a sustainable solution to this problem. The leading strategies for crop biofortification include agronomic practices, plant breeding and transgenic approaches. Previous reports have highlighted that agronomic practices are not very effective for iron biofortification of potato. However, extensive genetic variability for iron content in potato gene pool makes it an ideal crop for iron biofortification through genetic approaches. Therefore, genotypes with high iron content could be used as parental lines in potato breeding programs. The screening of genes or QTLs responsible for high iron content in these genotypes could pave the way for the development of iron biofortified potatoes through marker-assisted selection, speed breeding and transgenic approaches.
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References
Abebe T, Wongchaochant S, Taychasinpitak T, Leelapon O (2012) Variation of mineral concentrations among different potato varieties grown at two distinct locations in Ethiopia. Kasetsart J (Nat Sci) 46(6):837–850
Al-Jobori KM, Al-Hadithy SA (2014) Response of potato (Solanum tuberosum) to foliar application of iron, manganese, copper and zinc. Int J Agric Crop Sci 7:358–363
Andre CM, Ghislain M, Bertin P, Oufir M, del Rosario HM, Hoffmann L, Hausman JF, Larondelle Y, Evers D (2007) Andean potato cultivars (Solarium tuberosum L.) as a source of antioxidant and mineral micronutrients. J Agric Food Chem 55:366–378. https://doi.org/10.1021/jf062740i
Andre CM, Evers D, Ziebel J, Guignard C, Hausman JF, Bonierbale M, Zum Felde T, Burgos G (2015) In vitro bioaccessibility and bioavailability of iron from potatoes with varying vitamin C, carotenoid, and phenolic concentrations. J Agric Food Chem 63:9012–9021. https://doi.org/10.1021/acs.jafc.5b02904
Ariga T, Hazama K, Yanagisawa S, Yoneyama T (2014) Chemical forms of iron in xylem sap from graminaceous and non-graminaceous plants. Soil Sci Plant Nutr 60:460–469. https://doi.org/10.1080/00380768.2014.922406
Arora S, Cheema J, Poland J, Uauy C, Chhuneja P (2019) Genome-wide association mapping of grain micronutrients concentration in Aegilops tauschii. Front Plant Sci 10:54. https://doi.org/10.3389/fpls.2019.00054
Ashrafzadeh S, Gaw S, Genet R, Glover CN, Leung DW (2017) Natural variation in correlations between cadmium and micronutrients in potato tubers. J Food Compos Anal 59:55–60. https://doi.org/10.1016/j.jfca.2017.02.008
Bado S, Rafiri MA, El-Achouri K, Sapey E, Niele S, Ghanim AM, Forster BP, Laimer M (2016) In vitro methods for mutation induction in potato (Solanum tuberosum L.). Afr J Biotechnol 15:2132–2145. https://doi.org/10.5897/ajb2016.15571
Barberon M, Zelazny E, Robert S, Conéjéro G, Curie C, Friml J, Vert G (2011) Monoubiquitin-dependent endocytosis of the Iron-Regulated Transporter 1 (IRT1) transporter controls iron uptake in plants. Proc Natl Acad Sci U S A 108:E450–E458. https://doi.org/10.1073/pnas.1100659108
Barberon M, Dubeaux G, Kolb C, Isono E, Zelazny E, Vert G (2014) Polarization of IRON-REGULATED TRANSPORTER 1 (IRT1) to the plant-soil interface plays crucial role in metal homeostasis. Proc Natl Acad Sci U S A 111:8293–8298. https://doi.org/10.1073/pnas.1402262111
Berdugo-Cely J, Valbuena RI, Sánchez-Betancourt E, Barrero LS, Yockteng R (2017) Genetic diversity and association mapping in the Colombian Central Collection of Solanum tuberosum L. Andigenum group using SNPs markers. PLoS One 12:e0173039. https://doi.org/10.1371/journal.pone.0173039
Bilski J, Jacob D, Soumaila F, Kraft C, Farnsworth A (2012) Agronomic biofortification of cereal crop plants with Fe, Zn, and Se, by the utilization of coal fly ash as plant growth media. Adv Biores 3:130–136
Boamponsem GA, Leung DWM, Lister C (2017) Insights into resistance to Fe deficiency stress from a comparative study of in vitro-selected novel Fe-efficient and Fe-inefficient potato plants. Front Plant Sci 8:1581. https://doi.org/10.3389/fpls.2017.01581
Bradshaw JE (2019) Improving the nutritional value of potatoes by conventional breeding and genetic modification. In: Quality Breeding in Field Crops. Springer International Publishing, Cham, pp 41–84. https://doi.org/10.1007/978-3-030-04609-5_3
Brown CR (2008) Breeding for phytonutrient enhancement of potato. Am J Potato Res 85:298–307. https://doi.org/10.1007/s12230-008-9028-0
Brown CR, Haynes KG, Moore M, Pavek MJ, Hane DC, Love SL, Novy RG, Miller JC (2010) Stability and broad-sense heritability of mineral content in potato: iron. Am J Potato Res 87:390–396. https://doi.org/10.1007/s12230-010-9145-4
Brumbarova T, Bauer P, Ivanov R (2015) Molecular mechanisms governing Arabidopsis iron uptake. Trends Plant Sci 20:124–133. https://doi.org/10.1016/j.tplants.2014.11.004
Burgos G, Amoros W, Morote M, Stangoulis J, Bonierbale M (2007) Iron and zinc concentration of native Andean potato cultivars from a human nutrition perspective. J Sci Food Agric 87:668–675. https://doi.org/10.1002/jsfa.2765
Camaschella C (2019) Iron deficiency. Blood 133:30–39. https://doi.org/10.1182/blood-2018-05-815944
Camire ME, Kubow S, Donnelly DJ (2009) Potatoes and human health. Crit Rev Food Sci Nutr 49:823–840. https://doi.org/10.1080/10408390903041996
Cappellini MD, Musallam KM, Taher AT (2020) Iron deficiency anaemia revisited. J Intern Med 287:153–170. https://doi.org/10.1111/joim.13004
Carmona VM, Cecílio Filho AB, de Almeida HJ, Gratão PL (2019) Fortification and bioavailability of zinc in potato. J Sci Food Agric 99:3525–3529. https://doi.org/10.1002/jsfa.9572
Castaings L, Caquot A, Loubet S, Curie C (2016) The high-affinity metal transporters NRAMP1 and IRT1 team up to take up iron under sufficient metal provision. Sci Rep 6:37222. https://doi.org/10.1038/srep37222
Colangelo EP, Guerinot ML (2004) The essential basic helix-loop-helix protein FIT1 is required for the iron deficiency response. Plant Cell 16:3400–3412. https://doi.org/10.1105/tpc.104.024315
Connolly EL (2003) Overexpression of the FRO2 ferric chelate reductase confers tolerance to growth on low iron and uncovers posttranscriptional control. Plant Physiol 133:1102–1110. https://doi.org/10.1104/pp.103.025122
Connorton JM, Balk J (2019) Iron Biofortification of Staple Crops: Lessons and Challenges in Plant Genetics. Plant Cell Physiol 60:1447–1456. https://doi.org/10.1093/pcp/pcz079
Connorton JM, Balk J, Rodríguez-Celma J (2017) Iron homeostasis in plants-a brief overview. Metallomics 9:813–823. https://doi.org/10.1039/c7mt00136c
Conte SS, Walker EL (2011) Transporters contributing to iron trafficking in plants. Mol Plant 4:464–476. https://doi.org/10.1093/mp/ssr015
Cu ST, Guild G, Nicolson A, Velu G, Singh R, Stangoulis J (2020) Genetic dissection of zinc, iron, copper, manganese and phosphorus in wheat (Triticum aestivum L.) grain and rachis at two developmental stages. Plant Sci 291:110338. https://doi.org/10.1016/j.plantsci.2019.110338
Dalamu, Sharma J, Sharma V, Dua VK, Kumar V, Singh B (2017) Evaluation of Indian potato germplasm for iron and zinc content. Indian J Plant Genet Resour 30:232–236. https://doi.org/10.5958/0976-1926.2017.00029.8
Dalamu, Sharma J, Kumar S, Luthra SK, Sharma AK, Sharma V, Dua VK (2019) Mineral content of red skinned potatoes of Eastern India. J Hortic Sci 14:79–82
Dangol SD, Barakate A, Stephens J, Çalıskan ME, Bakhsh A (2019) Genome editing of potato using CRISPR technologies: current development and future prospective. Plant Cell Tissue Organ Cult 139:403–416. https://doi.org/10.1007/s11240-019-01662-y
de Haan S, Burgos G, Liria R, Rodriguez F, Creed-Kanashiro HM, Bonierbale M (2019) The nutritional contribution of potato varietal diversity in Andean food systems: a case study. Am J Potato Res 96:151–163. https://doi.org/10.1007/s12230-018-09707-2
Di Gioia F, Petropoulos SA, Ozores-Hampton M, Morgan K, Rosskopf EN (2019) Zinc and iron agronomic biofortification of Brassicaceae microgreens. Agronomy 9:677. https://doi.org/10.3390/agronomy9110677
Diretto G, Al-Babili S, Tavazza R, Papacchioli V, Beyer P, Giuliano G (2007) Metabolic engineering of potato carotenoid content through tuber-specific overexpression of a bacterial mini-pathway. PLoS One 2:e350. https://doi.org/10.1371/journal.pone.0000350
Durrett TP, Gassmann W, Rogers EE (2007) The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation. Plant Physiol 144:197–205. https://doi.org/10.1104/pp.107.097162
Fan W, Wang H, Wu Y, Yang N, Yang J, Zhang P (2017) H+-pyrophosphatase IbVP1 promotes efficient iron use in sweet potato [Ipomoea batatas (L.) Lam.]. Plant Biotechnol J 15:698–712. https://doi.org/10.1111/pbi.12667
Garg M, Sharma N, Sharma S, Kapoor P, Kumar A, Chunduri V, Arora P (2018) Biofortified crops generated by breeding, agronomy, and transgenic approaches are improving lives of millions of people around the world. Front Nutr 5:12. https://doi.org/10.3389/fnut.2018.00012
Giordano M, El-Nakhel C, Pannico A, Kyriacou MC, Stazi SR, De Pascale S, Rouphael Y (2019) Iron biofortification of red and green pigmented lettuce in closed soilless cultivation impacts crop performance and modulates mineral and bioactive composition. Agronomy 9:290. https://doi.org/10.3390/agronomy9060290
Gödecke T, Stein AJ, Qaim M (2018) The global burden of chronic and hidden hunger: Trends and determinants. Glob Food Sec 17:21–29. https://doi.org/10.1016/j.gfs.2018.03.004
Gollhofer J, Timofeev R, Lan P, Schmidt W, Buckhout TJ (2014) Vacuolar-iron-transporter1-like proteins mediate iron homeostasis in arabidopsis. PLoS One 9:e110468. https://doi.org/10.1371/journal.pone.0110468
Green LS, Rogers EE (2004) FRD3 controls iron localization in Arabidopsis. Plant Physiol 136:2523–2531. https://doi.org/10.1104/pp.104.045633
Gupta DS, Mc Phee K, Kumar S (2017) Development of molecular markers for iron metabolism related genes in lentil and their expression analysis under excess iron stress. Front Plant Sci 8:579. https://doi.org/10.3389/fpls.2017.00579
Haynes KG, Yencho GC, Clough ME, Henninger MR, Sterrett SB (2012) Genetic variation for potato tuber micronutrient content and implications for biofortification of potatoes to reduce micronutrient malnutrition. Am J Potato Res 89:192–198. https://doi.org/10.1007/s12230-012-9242-7
Hell R, Stephan UW (2003) Iron uptake, trafficking and homeostasis in plants. Planta 216:541–551. https://doi.org/10.1007/s00425-002-0920-4
Horton S (2006) The economics of food fortification. J Nutr 136:1068–1071. https://doi.org/10.1093/jn/136.4.1068
Ihemere UE, Narayanan NN, Sayre RT (2012) Iron biofortification and homeostasis in transgenic cassava roots expressing the algal iron assimilatory gene, FEA1. Front Plant Sci 3:171. https://doi.org/10.3389/fpls.2012.00171
Jain A, Wilson GT, Connolly EL (2014) The diverse roles of FRO family metalloreductases in iron and copper homeostasis. Front Plant Sci 5:100. https://doi.org/10.3389/fpls.2014.00100
Jakoby M, Wang HY, Reidt W, Weisshaar B, Bauer P (2004) FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana. FEBS Lett 577:528–534. https://doi.org/10.1016/j.febslet.2004.10.062
Jeong J, Connolly EL (2009) Iron uptake mechanisms in plants: functions of the FRO family of ferric reductases. Plant Sci 176:709–714. https://doi.org/10.1016/j.plantsci.2009.02.011
Jeong J, Merkovich A, Clyne M, Connolly EL (2017) Directing iron transport in dicots: regulation of iron acquisition and translocation. Curr Opin Plant Biol 39:106–113. https://doi.org/10.1016/j.pbi.2017.06.014
Jongstra R, Mwangi MN, Burgos G, Zeder C, Low JW, Mzembe G, Liria R, Penny M, Andrade MI, Fairweather-Tait S, Zum Felde T (2020) Iron absorption from iron-biofortified sweetpotato is higher than regular sweetpotato in Malawian women while iron absorption from regular and iron-biofortified potatoes is high in Peruvian women. J Nutr 150:3094–3102. https://doi.org/10.1093/jn/nxaa267
Karley AJ, White PJ (2009) Moving cationic minerals to edible tissues: potassium, magnesium, calcium. Curr Opin Plant Biol 2:291–298. https://doi.org/10.1016/j.pbi.2009.04.013
Kenzhebayeva S, Abekova A, Atabayeva S, Yernazarova G, Omirbekova N, Zhang G, Turasheva S, Asrandina S, Sarsu F, Wang Y (2019) Mutant lines of spring wheat with increased iron, zinc, and micronutrients in grains and enhanced bioavailability for human health. Biomed Res Int 2019:9692053–9692010. https://doi.org/10.1155/2019/9692053
Khan A, Singh P, Srivastava A (2018) Synthesis, nature and utility of universal iron chelator – Siderophore: A review. Microbiol Res 212:103–111. https://doi.org/10.1016/j.micres.2017.10.012
Kim SA, Punshon T, Lanzirotti A, Li L, Alonso JM, Ecker JR, Kaplan J, Guerinot ML (2006) Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1. Science 314:1295–1298. https://doi.org/10.1126/science.1132563
King JC, Slavin JL (2013) White potatoes, human health, and dietary guidance. Adv Nutr 4:393S–401S. https://doi.org/10.3945/an.112.003525
Kobayashi T, Nishizawa NK (2012) Iron uptake, translocation, and regulation in higher plants. Annu Rev Plant Biol 63:131–152. https://doi.org/10.1146/annurev-arplant-042811-105522
Kobayashi T, Nozoye T, Nishizawa NK (2019) Iron transport and its regulation in plants. Free Radic Biol Med 133:11–20. https://doi.org/10.1016/j.freeradbiomed.2018.10.439
Kromann P, Valverde F, Alvarado S, Vélez R, Pisuña J, Potosí B, Taipe A, Caballero D, Cabezas A, Devaux A (2017) Can Andean potatoes be agronomically biofortified with iron and zinc fertilizers? Plant Soil 411:121–138. https://doi.org/10.1007/s11104-016-3065-0
Kumar S, Palve A, Joshi C, Srivastava RK (2019) Crop biofortification for iron (Fe), zinc (Zn) and vitamin A with transgenic approaches. Heliyon 5:e01914. https://doi.org/10.1016/j.heliyon.2019.e01914
Legay S, Guignard C, Ziebel J, Evers D (2012) Iron uptake and homeostasis related genes in potato cultivated in vitro under iron deficiency and overload. Plant Physiol Biochem 60:180–189. https://doi.org/10.1016/j.plaphy.2012.08.003
Long TA, Tsukagoshi H, Busch W, Lahner B, Salt DE, Benfey PN (2010) The bHLH transcription factor POPEYE regulates response to iron deficiency in arabidopsis roots. Plant Cell 22:2219–2236. https://doi.org/10.1105/tpc.110.074096
Lutaladio NB, Castaldi L (2009) Potato: The hidden treasure. J Food Compos Anal 22:491–493. https://doi.org/10.1016/j.jfca.2009.05.002
Masuda H, Aung MS, Kobayashi T, Nishizawa NK (2020) Iron biofortification: the gateway to overcoming hidden hunger. In: The Future of Rice Demand: Quality Beyond Productivity pp 149-177. https://doi.org/10.1007/978-3-030-37510-2_7
Moinuddin G, Jash S, Sarkar A, Dasgupta S (2017) Response of potato (Solanum tuberosum L.) to foliar application of macro and micronutrients in the Red and Lateritic Zone of West Bengal. J Crop Weed 13:185–188
Morrissey J, Guerinot ML (2009) Iron uptake and transport in plants: The good, the bad, and the ionome. Chem Rev 109:4553–4567. https://doi.org/10.1021/cr900112r
Narayanan N, Beyene G, Chauhan RD, Gaitán-Solis E, Grusak MA, Taylor N, Anderson P (2015) Overexpression of Arabidopsis VIT1 increases accumulation of iron in cassava roots and stems. Plant Sci 240:170–181. https://doi.org/10.1016/j.plantsci.2015.09.007
Narayanan N, Beyene G, Chauhan RD, Gaitán-Solís E, Gehan J, Butts P, Siritunga D, Okwuonu I, Woll A, Jiménez-Aguilar DM, Boy E (2019) Biofortification of field-grown cassava by engineering expression of an iron transporter and ferritin. Nat Biotechnol 37:144–151. https://doi.org/10.1038/s41587-018-0002-1
NIH (2018) Iron - Health Professional Fact Sheet. In: US Dep. Heal. Hum. Serv.
Öztürk E, Atsan E, Polat T, Kara K (2011) Variation in heavy metal concentrations of potato (Solanum tuberosum L.) cultivars. J Anim Plant Sci 21:235–239
Paget M, Amoros W, Salas E, Eyzaguirre R, Alspach P, Apiolaza L, Noble A, Bonierbale M (2014) Genetic evaluation of micronutrient traits in diploid potato from a base population of Andean Landrace Cultivars. Crop Sci 54:1949–1959. https://doi.org/10.2135/cropsci2013.12.0809
Pasricha SR, Drakesmith H, Black J, Hipgrave D, Biggs BA (2013) Control of iron deficiency anemia in low- and middle-income countries. Blood 121:2607–2617. https://doi.org/10.1182/blood-2012-09-453522
Pivina L, Semenova Y, Doşa MD, Dauletyarova M, Bjørklund G (2019) Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children. J Mol Neurosci 68:1–10. https://doi.org/10.1007/s12031-019-01276-1
Rehman AU, Masood S, Khan NU, Abbasi ME, Hussain Z, Ali I (2020) Molecular basis of Iron Biofortification in crop plants; a step towards sustainability. Plant Breed 140:12–22. https://doi.org/10.1111/pbr.12886
Reis S, Pavia I, Carvalho A, Moutinho-Pereira J, Correia C, Lima-Brito J (2018) Seed priming with iron and zinc in bread wheat: effects in germination, mitosis and grain yield. Protoplasma 255:1179–1194. https://doi.org/10.1007/s00709-018-1222-4
Roschzttardtz H, Séguéla-Arnaud M, Briat JF, Vert G, Curie C (2011) The FRD3 citrate effluxer promotes iron nutrition between symplastically disconnected tissues throughout Arabidopsis development. Plant Cell 23:2725–2737. https://doi.org/10.1105/tpc.111.088088
Santi S, Schmidt W (2009) Dissecting iron deficiency-induced proton extrusion in Arabidopsis roots. New Phytol 183:1072–1084. https://doi.org/10.1111/j.1469-8137.2009.02908.x
Satbhai SB, Setzer C, Freynschlag F, Slovak R, Kerdaffrec E, Busch W (2017) Natural allelic variation of FRO2 modulates Arabidopsis root growth under iron deficiency. Nat Commun 8:1. https://doi.org/10.1038/ncomms15603
Sharifi R (2016) Effect of seed priming and foliar application with micronutrients on quality of forage corn (Zea mays). Environ Exp Biol 14:151–156. https://doi.org/10.22364/eeb.14.21
Sharma R, Yeh KC (2020) The dual benefit of a dominant mutation in Arabidopsis IRON DEFICIENCY TOLERANT1 for iron biofortification and heavy metal phytoremediation. Plant Biotechnol J 18:1200–1210. https://doi.org/10.1111/pbi.13285
Sharma J, Dalamu, Dua VK, Gupta VK, Kumar D (2017) Variations in micronutrient content in tubers of Indian potato varieties. Potato J 44:101–109
Singh B, Bhardwaj V, Kaur K, Kukreja S, Goutam U (2020a) Potato periderm is the first layer of defence against biotic and abiotic stresses: a review. Potato Res 1-6. https://doi.org/10.1007/s11540-020-09468-8
Singh B, Sharma J, Sood S, Kardile HB, Kumar A, Goutam U, Bhardwaj V (2020b) Genetic variability for micronutrient content in andigena potato genotypes. Plant Cell Biotechnol Mol Biol 21:1–10
Subramanian NK, White PJ, Broadley MR, Ramsay G (2011) The three-dimensional distribution of minerals in potato tubers. Ann Bot 107:681–691. https://doi.org/10.1093/aob/mcr009
Subramanian NK, White PJ, Broadley MR, Ramsay G (2017) Variation in tuber mineral concentrations among accessions of Solanum species held in the Commonwealth Potato Collection. Genet Resour Crop Evol 64:1927–1935. https://doi.org/10.1007/s10722-016-0483-z
Sundaria N, Singh M, Upreti P, Chauhan RP, Jaiswal JP, Kumar A (2019) Seed priming with iron oxide nanoparticles triggers iron acquisition and biofortification in wheat (Triticum aestivum L.) grains. J Plant Growth Regul 38:122–131. https://doi.org/10.1007/s00344-018-9818-7
Suzuki M, Morikawa KC, Nakanishi H, Takahashi M, Saigusa M, Mori S, Nishizawa NK (2008) Transgenic rice lines that include barley genes have increased tolerance to low iron availability in a calcareous paddy soil. Soil Sci Plant Nutr 54:77–85. https://doi.org/10.1111/j.1747-0765.2007.00205.x
Tran PT, Ho CQ (2017) Breeding new aromatic rice with high iron using gamma radiation and hybridization BT - biotechnologies for plant mutation breeding: protocols. In: Biotechnologies for Plant Mutation Breeding
Tripathi A, Mishra S (2020) Food fortification reduces micronutrient deficiency without increasing economic stress. Food Nutr Bull 037957212093854. https://doi.org/10.1177/0379572120938548
Trofimov K, Ivanov R, Eutebach M, Acaroglu B, Mohr I, Bauer P, Brumbarova T (2019) Mobility and localization of the iron deficiency-induced transcription factor bHLH039 change in the presence of FIT. Plant Direct 3:e00190. https://doi.org/10.1002/pld3.190
Vergara Carmona VM, Cecílio Filho AB, de Almeida HJ, Gratão PL (2019) Fortification and bioavailability of zinc in potato. J Sci Food Agric 99:3525–3529. https://doi.org/10.1002/jsfa.9572
Vert G, Grotz N, Dédaldéchamp F, Gaymard F, Guerinot ML, Briat JF, Curie C (2002) IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth. Plant Cell 14:1223–1233. https://doi.org/10.1105/tpc.001388
Von Wiren N, Klair S, Bansal S, Briat JF, Khodr H, Shioiri T, Leigh RA, Hider RC (1999) Nicotianamine chelates both Fe(III) and Fe(II) implications for metal transport in plants. Plant Physiol 119:1107–1114. https://doi.org/10.1104/pp.119.3.1107
White PJ, Thompson JA, Wright G, Rasmussen SK (2017) Biofortifying Scottish potatoes with zinc. Plant Soil 411:151–165. https://doi.org/10.1007/s11104-016-2903-4
Zia MAB, Bakhsh A, Çalıskan ME (2018) Mutation breeding in potato; endeavors and challenges. J Anim Plant Sci 28:177–186
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This study was financed by Department of Science and Technology-Science and Engineering Research Board (DST-SERB) in the form of an externally funded project to Indian Council of Agricultural Research - Central Potato Research Institute (ICAR-CPRI), Shimla, India
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Singh, B., Goutam, U., Kukreja, S. et al. Biofortification Strategies to Improve Iron Concentrations in Potato Tubers: Lessons and Future Opportunities. Potato Res. 65, 51–64 (2022). https://doi.org/10.1007/s11540-021-09508-x
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DOI: https://doi.org/10.1007/s11540-021-09508-x