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Highly Sensitive Plasmonic Biosensor for the Detection of Chikungunya Virus Employing TiO2 and BP/WS2 Heterostructure

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Abstract

A surface plasmon resonance–based biosensor for the detection of chikungunya virus has been proposed in this article. The structure of the sensor is based on the Kretschmann configuration, which includes a BK7 prism, silver (Ag) metal, titanium dioxide (TiO2), a perovskite material (BaTiO3), and a heterostructure 2D nanomaterial (blue phosphorene/tungsten disulfide; BP/WS2). The surface of the 2D heterostructure material is employed for the detection of the analyte, aiming to investigating the alterations in refractive index. Using the transfer matrix method (TMM), the reflectivity of the proposed sensor is analyzed numerically. The investigation also explores the enhancement of sensitivity by considering variations in number and thickness of layers. To confirm the location of resonance angle and substantiate the ultrahigh sensitivity, an examination of the electric field intensity enhancement factor and normalized electric field distribution has been also conducted. The optimization of parameters for the proposed sensor revealed that platelets and plasma cells have a maximum sensitivity of 365°/RIU and 152°/RIU, figures of merit of 94.147 and 73.98, and detection accuracy of 0.2579 and 0.4859 deg−1. The normalized electric field plot suggests a penetration depth of the order of 102 nm which enables long-range sensing and strong field-analyte interaction. The sensor offers high sensitivity and stability and may find useful applications in biomedical industries.

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Data Availability

No datasets were generated or analyzed during the current study.

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Funding

This work was funded by the Researchers Supporting Project (Number RSP2024R161) King Saud University, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Photonics and Photovoltaic Research Lab (PPRL), Department of Physics and Material Science, Madan Mohan Malaviya University of Technology, Gorakhpur, India, 273010

    Yashaswini Singh, D. K. Dwivedi, Adarsh Chandra Mishra & Sapana Yadav

  2. Department of Electronics and Communication Engineering, Madan Mohan Malaviya University of Technology, Gorakhpur, India, 273010

    Pooja Lohia

  3. Department of Chemistry, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia

    Gaber E. Eldesoky

  4. Institute of Electronics Atomic Energy Research Establishment, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh, 1349

    M. Khalid Hossain

Authors
  1. Yashaswini Singh
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  2. D. K. Dwivedi
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  3. Pooja Lohia
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  4. Adarsh Chandra Mishra
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  5. Sapana Yadav
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  6. Gaber E. Eldesoky
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  7. M. Khalid Hossain
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Contributions

Yashaswini Singh wrote original manuscript and analyzed the results, Adarsh Chandra Mishra and Sapana Yadav provided software support, conceptualized and reviewed the work, while Pooja Lohia, M. Khalid Hossain, D.K. Dwivedi and Gaber E. Eldesoky reviewed, edited and supervised the work.

Corresponding author

Correspondence to D. K. Dwivedi.

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Singh, Y., Dwivedi, D.K., Lohia, P. et al. Highly Sensitive Plasmonic Biosensor for the Detection of Chikungunya Virus Employing TiO2 and BP/WS2 Heterostructure. Plasmonics (2024). https://doi.org/10.1007/s11468-024-02242-3

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