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Sonodynamic therapy (SDT): a novel strategy for cancer nanotheranostics

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Abstract

Sonodynamic therapy (SDT) is a promising non-invasive therapeutic modality. Compared to photo-inspired therapy, SDT provides many opportunities and benefits, including deeper tissue penetration, high precision, less side effects, and good patient compliance. Thanks to the facile engineerable nature of nanotechnology, nanoparticles-based sonosensitizers exhibit predominant advantages, such as increased SDT efficacy, binding avidity, and targeting specificity. This review aims to summarize the possible mechanisms of SDT, which can be expected to provide the theoretical basis for SDT development in the future. We also extensively discuss nanoparticle-assisted sonosensitizers to enhance the outcome of SDT. Additionally, we focus on the potential strategy of combinational SDT with other therapeutic modalities and discuss the limitations and challenges of SDT toward clinical applications.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (51572271, 51772018), National Basic Research Program of China (2016YFA0201500) and Fundamental Research Funds for the Central Universities (buctrc201610, JD1609, PYBZ1705).

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Authors and Affiliations

  1. Beijing Key Laboratory of Bioprocess, Bionanomaterials & Translational Engineering Laboratory, State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China

    Xueting Pan, Hongyu Wang, Shunhao Wang, Xiao Sun, Lingjuan Wang, Weiwei Wang, Heyun Shen & Huiyu Liu

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  1. Xueting Pan
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  2. Hongyu Wang
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  3. Shunhao Wang
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Correspondence to Huiyu Liu.

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Pan, X., Wang, H., Wang, S. et al. Sonodynamic therapy (SDT): a novel strategy for cancer nanotheranostics. Sci. China Life Sci. 61, 415–426 (2018). https://doi.org/10.1007/s11427-017-9262-x

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