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Development of a Novel Sonosensitizer for Sonodynamic Therapy

  • Conference paper
  • First Online:
9th International Conference on the Development of Biomedical Engineering in Vietnam (BME 2022)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 95))

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Abstract

Sonodynamic therapy (SDT) is a non-invasive treatment for various cancers. Because ultrasound was used to provide energy requirement for ROS, the main advantage of SDT over PDT (photodynamic therapy) is the much greater tissue depth than photodynamic therapy (PDT). The therapeutic mechanism of SDT combined with ultrasound and chemotherapeutic drugs (sonosensitizers) is a promising alternative to eradicate tumors. In this study, we synthesized a new generation of photosensitizer 3,7-bis(di(2-(dimethylamino)ethyl)amino)-phenothiazin-5-ium iodide (MB-N) and developed its possibility to be a sonosensitizers with characterizing the best ROS generation by spectroscopic analysis. The methylene blue (MB) was used to explore the efficiency difference between PDT and SDT induced by photosensitizer and sonosensitizer, as a basis for studying other sonosensitizers.

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Author information

Authors and Affiliations

  1. Office of Physical Education, Tamkang University, New Taipei City, Taiwan

    Tun-Pin Hung

  2. Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan

    Chia-Feng Hsieh & Cheng-Chung Chang

  3. Intelligent Minimally-Invasive Device Center, National Chung Hsing University, Taichung, Taiwan

    Cheng-Chung Chang

Authors
  1. Tun-Pin Hung
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  2. Chia-Feng Hsieh
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  3. Cheng-Chung Chang
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Corresponding author

Correspondence to Cheng-Chung Chang .

Editor information

Editors and Affiliations

  1. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Van Toi Vo

  2. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Thi-Hiep Nguyen

  3. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Binh Long Vong

  4. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Ngoc Bich Le

  5. School of Biomedical Engineering, International University—Vietnam National University, Ho Chi Minh City, Vietnam

    Thanh Qua Nguyen

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© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Hung, TP., Hsieh, CF., Chang, CC. (2024). Development of a Novel Sonosensitizer for Sonodynamic Therapy. In: Vo, V.T., Nguyen, TH., Vong, B.L., Le, N.B., Nguyen, T.Q. (eds) 9th International Conference on the Development of Biomedical Engineering in Vietnam. BME 2022. IFMBE Proceedings, vol 95. Springer, Cham. https://doi.org/10.1007/978-3-031-44630-6_31

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  • DOI: https://doi.org/10.1007/978-3-031-44630-6_31

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-44629-0

  • Online ISBN: 978-3-031-44630-6

  • eBook Packages: EngineeringEngineering (R0)

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