Skip to main content

Advertisement

Log in

Excessive use of nitrogenous fertilizers: an unawareness causing serious threats to environment and human health

  • Trend Editorial
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

Farmers occasionally need to add nitrogen fertilizer to their farms and gardens to make available just the precise nutrients for their plants’ growth. The applications of inorganic nitrogen fertilizers to various crops have been continuously increasing since last many decades globally. Although nitrogen fertilizer contributes substantially to yield enhancement, but excessive use of this manure has posed serious threats to environment and human health. Rate of nitrogen fertilizers application has a close relationship with nitrate accumulation in surrounding environment, groundwater, as well as leafy and root vegetables. Consumption of diets having high nitrate contents has contributed to endogenous nitrosation, which could lead to thyroid condition, various kinds of human cancers, neural tube defects (during fetus development), and diabetes. In this short review, the authors have tried to create awareness among general public, farming community, health practitioners, and agricultural scientists for the risk involved with excessive use of nitrogen fertilizers to human health. Carcinogenic activity and other adverse effects of N-nitroso compounds might be prevented by consuming vitamin C and antioxidants containing fruits and vegetables.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  • Bahadoran Z, Ghasemi A, Mirmiran P, Azizi F, Hadaegh F (2016) Nitrate-nitrite-nitrosamines exposure and the risk of type 1 diabetes: a review of current data. World J Diabetes 7:433

    Article  Google Scholar 

  • Bivolarska A, Gatseva P (2015) Thyroid status in pregnant woman and association with nitrates as an environmental factor stimulating the manifestation of iodine deficiency. Trace Elem Elec 32:60–64

  • Catsburg CE, Gago-Dominguez M, Yuan JM, Castelao JE, Cortessis VK, Pike MC, Stern MC (2014) Dietary source of N-nitroso compounds and bladder cancer risk: finding from Los Angeles bladder cancer study. Intl J Cancer 134:125–135. https://doi.org/10.1002/ijc.28331

    Article  Google Scholar 

  • Crawford NM, Glass AD (1998) Molecular and physiological aspects of nitrate uptake in plants. Trends Plant Sci 3:389–395

    Article  Google Scholar 

  • Donner SD, Kucharik JA (2003) Evaluating the impacts of land management and climate variability on crop production and nitrate export across Upper Mississipi Basin. Global Biogeochem Cycle 17(3):1085. https://doi.org/10.1029/2001GB001808.

  • Fan XH, Li YC (2010) Nitrogen release from slow-release fertilizers as affected by soil type and temperature. Soil Sci Soc Amer J 74:1635–1641

    Article  CAS  Google Scholar 

  • Ferrucci LM, Sinha R, Ward MH, Graubard BI, Hollenbeck AR, Kilfoy BA, Schatzkin A, Michaud DS, Cross AJ (2010) Meat and components of meat and the risk of bladder cancer in yhe NIH-AARP Diet and Health Study. Cancer 116:4345–4353. https://doi.org/10.1002/cncr.25463

    Article  Google Scholar 

  • Gastal F, Lemaire G (2002) N uptake and distribution in crops: an agronomical and ecophysiological perspective. J Exp Bot 53:789–799

    Article  CAS  Google Scholar 

  • Ginting D, Kessavalou A, Eghball B, Doran JW (2003) Greenhouse gas emissions and soil indicators four years after manure compost applications. J Environ Qual 32:23–32

    Article  CAS  Google Scholar 

  • Griffin TS (2008) Nitrogen availability. Nitrogen in agricultural systems. In: Schepers J, Ruan WR (eds) . SSSA Inc. and ASA Inc, Madisin, WI, USA, pp 613–646

    Google Scholar 

  • Guglielmi G (2017) Arsenic in drinking water threatens up to 60 million in Pakistan. https://doi.org/10.1126/science.aap7590 (http://www.sciencemag.org/news/2017/08/arsenic-drinking-water-threatens-60-million-pakistan)

  • Han M, Wong J, Su T, Beatty PH, Good AG (2016) Identification of nitrogen use efficiency genes in barley: searching for QTLs controlling complex physiological traits. Front Plant Sci 7:1587–1604

    Google Scholar 

  • IARC (International Agency for Research on Cancer) (2010) Ingested nitrate and nitrite and cyanobacterial peptide toxins. World Health Organization (WHO), International Agency for Research on Cancer. IARC Monogr Eval Carcinog Risks Hum 94:1–464

  • IFA International Fertilizer Association (2016) International Fertilizer Association 84th IFA Annual Conference Moscow, Russia (30 May - 1 June 2016). http://www.fertilizer.org/

  • IFA: International Fertilizer Association (2011) International Fertilizer Association 79th IFA Annual Conference Montreal, Canada (23–25 May 2011). http://www.fertilizer.org/

  • Jones RR, Weyer PJ, Curt T, Valle D, Choi MI, Anderson KE, Cantor KP, Krasner S, Robein K, Laura E, Freeman B, Silverman DT, Ward MH (2016) Nitrate from drinking water and diet and bladder cancer among postmenopausal women in Iowa. Environ Health Perspective 124:1751–1758

    Article  Google Scholar 

  • Kristensen P, Andersen A, Irgens LM, Bye AS, Vagstad N (1996) Testicular cancer and parental use of fertilizers in agriculture. Cancer Epidem Biomar 5:3–9

    CAS  Google Scholar 

  • Lin TY, Wei CC, Huang CW, Chang CH, Hsu FL, Liao VH (2016) Both phosphorus fertilizers and indigenous bacteria enhance arsenic release into groundwater in arsenic-contaminated aquifers. J Agric Food Chem 64:2214–2222

    Article  CAS  Google Scholar 

  • Liu CW, Sung Y, Chen BC, Lai HY (2014) Effects of nitrogen fertilizers on the growth and nitrate content of lettuce (Lactuca sativa L.) Intl J Environ Res Public Health 11:4427–4440

    Article  CAS  Google Scholar 

  • Lobell DB (2007) The cost of uncertainty for nitrogen fertilizer management: a sensitivity analysis. Field Crop Res 100:210–217

    Article  Google Scholar 

  • Majumdar D (2003) The blue baby syndrome: nitrate poisoning in humans. Resonance 8:20–30

    Article  Google Scholar 

  • Majumdar D, Gupta N (2000) Nitrate pollution of groundwater and associated human health disorders. Ind J Environ Health 42:28–39

    CAS  Google Scholar 

  • Manassaram DM, Backer LC, Moll DM (2006) A review of nitrates in drinking water: maternal exposure and adverse reproductive and developmental outcomes. Environ Health Perspect 114:320–327

  • Mensinga TT, Speijers GJ, Meullenbelt J (2003) Health implications of exposure to environmental nitrogenous compounds. Toxicol Rev 22:41–51

    Article  CAS  Google Scholar 

  • Ng JMS, Han M, Beatty PH, Good A (2016) Genes, meet gases: the role of plant nutrition and genomics in addressing greenhouse gas emissions. In: Edwards D, Batley J (eds) in Plant Genomics and Climate Change. Springer, New York, NY, pp 149–172

    Chapter  Google Scholar 

  • Polya D, Charlet L (2009) Environmental science: rising arsenic risk? Nat Geosci 2(6):383

    Article  CAS  Google Scholar 

  • Santamaria P (2006) Nitrate in vegetables: toxicity, content, intake and EC regulation. J Sci Food Agri 86:10–17

    Article  CAS  Google Scholar 

  • Sharifi M, Zebarth BJ, Burton DL, Rodd V, Grant CA (2011) Long-term effects of semisolid beef manure application to forage grass on soil mineralizable nitrogen. Soil Sci Soc Amer J 75:649–658

    Article  CAS  Google Scholar 

  • Smith AH, Hopenhayn-Rich C, Bates MN, Goeden HM, Hertz-Picciotto I, Duggan HM, Wood R, Kosnett MJ, Smith MT (1992) Cancer risks from arsenic in drinking water. Environ Health Perspective 97:259

    Article  CAS  Google Scholar 

  • Tamme T, Reinik M, Roasto M (2009) Nitrates and nitrites in vegetables: occurrence and health risk. In Bioactive foods promoting health: fruits and vegetables. In: Watson RR, Preedy VR (eds) . Academic Press, Salt Lake City, UT, USA, pp 307–321

    Google Scholar 

  • Tilman D, Cassman KG, Matson PA, Naylor R, Polasky S (2002) Agricultural sustainability and intensive production practices. Nature 418:671–677

    Article  CAS  Google Scholar 

  • Tricker AR (1997) N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. Eur J Cancer Prev 6:226–268

    Article  CAS  Google Scholar 

  • Uddin MS, Kurosawa K (2011) Effect of chemical nitrogen fertilizer application on the release of arsenic from sediment to groundwater in Bangladesh. Procedia Environ Sci 4:294–302

    Article  Google Scholar 

  • Van Velzen AG, Sips AJAM, Schothorst RC, Lambers AC, Meulenbelt J (2008) The oral bioavailability of nitrate from nitrate-rich vegetables in humans. Toxicol Lett 181:177–181

  • Wang ZH, Zong ZQ, Li SX, Chen BM (2002) Nitrate accumulation in vegetables and its residual in vegetable fields. Environ Sci 23:789–799

    Google Scholar 

  • Ward MH (2009) Too much of a good thing? Nitrate from nitrogen fertilizers and cancer. Rev Environ Health 24:357–363

    Article  CAS  Google Scholar 

  • Ward MH, Heineman EF, McComb RD, Weisenburger DD (2005) Drinking water and dietary sources of nitrate and nitrite and risk of glioma. J Occup Environ Med 47:1260–1267

    Article  CAS  Google Scholar 

  • Watts DB, Torbert HA, Prior SA, Huluka G (2010) Long-term tillage and poultry litter impacts soil carbon and nitrogen mineralization and fertility. Soil Sci Soc Amer J 74:1239–1247

    Article  CAS  Google Scholar 

  • WHO (2011) Guidelines for drinking-water quality, 4th edn. World Health Organization, Geneva, pp 541

  • Wuebbles DJ (2009) Nitrous oxide: no laughing matter. Science 326:56–57

    Article  CAS  Google Scholar 

  • Yara Fertilizer Industry Handbook (2017) http://yara.com/doc/245619_Fertilizer_Industry_Handbook_2017.pdf

  • Zahoor WA, Khanzada H, Bashir U, Aziz K, Zahir S, Faheem AK (2014) Role of nitrogen fertilizer in crop productivity and environmental pollution. Int J Agric For 4:201–206

    Google Scholar 

  • Zaldívar R, Robinson H (1973) Epidemiological investigation on stomach cancer mortality in Chileans: association with nitrate fertilizer. Zeitschrift für Krebsforschung und Klinische Onkologie 80:289–295

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Moddassir Ahmed.

Additional information

Responsible editor: Philippe Garrigues

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ahmed, M., Rauf, M., Mukhtar, Z. et al. Excessive use of nitrogenous fertilizers: an unawareness causing serious threats to environment and human health. Environ Sci Pollut Res 24, 26983–26987 (2017). https://doi.org/10.1007/s11356-017-0589-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-017-0589-7

Keywords

Navigation