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Quantitative evaluation of bone single-photon emission computed tomography using Z score analysis in patients with mandibular osteomyelitis

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Abstract

Objectives

Bone scintigraphy is a functional imaging that allows early detection of bone changes, providing high sensitivity to detect osteomyelitis. The aims of this study were to develop a quantitative evaluation method for bone SPECT images of mandibular osteomyelitis, and to confirm the reliability of this method by comparing the results with the conventional subjective evaluation and other findings.

Methods

The study included 139 patients with suspected mandibular osteomyelitis who were examined by bone SPECT. Tc-99 m uptake in mandibular lesions was subjectively evaluated by comparing with that of cervical vertebrae and categorized into 5 groups. For quantitative evaluation of Tc-99 m uptake, we developed an anatomical standardization followed by Z-score analysis applied to the diagnosis of brain neurodegenerative disease. To confirm reliability, the correlation between subjective evaluation and Z-score was evaluated. Further, the relationship between the Z-score and CT findings suggestive of osteomyelitis was also evaluated.

Results

The correlation coefficient of voxel values was significantly improved by anatomical standardization. The Z-score of osteomyelitis was significantly correlated with subjective evaluation. It was also related to some of the CT findings (bone absorption, periosteal reaction, surrounding soft tissue inflammation).

Conclusions

We developed the quantitative evaluation method of the mandible on bone SPECT images using anatomical standardization followed by Z-score analysis, and it was considered useful for evaluating mandibular osteomyelitis quantitatively.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Radiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Sakurako Asai, Shin Nakamura & Tohru Kurabayashi

  2. Department of Diagnostic Radiology and Nuclear Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Akira Toriihara & Ukihide Tateishi

Authors
  1. Sakurako Asai
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  2. Shin Nakamura
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  3. Akira Toriihara
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  4. Ukihide Tateishi
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  5. Tohru Kurabayashi
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Corresponding author

Correspondence to Shin Nakamura.

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All authors declare that they have no conflict of interest.

Ethical standards

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with Helsinki Declaration of 1975, as revised in 2008. Informed consent from each patient was waived because of the retrospective nature of the study.

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Asai, S., Nakamura, S., Toriihara, A. et al. Quantitative evaluation of bone single-photon emission computed tomography using Z score analysis in patients with mandibular osteomyelitis. Oral Radiol 36, 267–274 (2020). https://doi.org/10.1007/s11282-019-00407-z

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  • DOI: https://doi.org/10.1007/s11282-019-00407-z

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