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Health-related quality of life in Parkinson’s disease: systematic review and meta-analysis of EuroQol (EQ-5D) utility scores

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Abstract

Introduction

Evaluating the Health-related quality of life (HRQoL) of individuals with Parkinson’s disease (PD) holds significant importance in clinical and research settings. The EQ-5D is a widely recognized tool for comprehensive measurement of HRQoL using utility values. This study aims to systematically review and synthesize EQ-5D utility values from existing literature on patients with PD and their caregivers.

Methods

We conducted a systematic search for studies that provided EQ-5D utility scores for patients with PD, using PubMed-Medline, Scopus, and Embase and selected the studies. The selected studies underwent systematic review, including an assessment of their quality. We performed a meta-analysis using a random-effect model and conducted a meta-regression analysis to investigate sources of heterogeneity among the studies.

Results

The search result of 13,417 articles that were reviewed, 130 studies with 33,914 participants were selected for systematic review, and 79 studies were included for meta-analysis. The pooled EQ-5D utility values and visual analog score (VAS) among PD were 62.72% (60.53–64.93, I2 = 99.56%) and 0.60 (0.55–0.65, I2 = 99.81%), respectively. The pooled scores for caregivers’ EQ-VAS and EQ-5D utility were 70.10% (63.99–76.20, I2 = 98.25%) and 0.71 (0.61–0.81, I2 = 94.88%), respectively. Disease duration (P < 0.05) showed a negative correlation with EQ-5D utility values on meta-regression.

Conclusion

The pooled utility values of PD and their caregivers help to understand their HRQoL and aid in conducting health economics research. The negative association between disease duration and utility values highlights the evolving nature of HRQoL challenges, suggesting the need for appropriate long-term disease management.

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Data availability

All the data is included in the manuscript &/or in the online supplementary material.

References

  1. DeMaagd, G., & Philip, A. (2015). Parkinson’s disease and its management: Part 1: Disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis. Pharmacy and Therapeutics, 40(8), 504–532.

    PubMed  PubMed Central  Google Scholar 

  2. Liaison, C. A. P., (2015) Parkinson’s disease: Challenges, progress, and promise, NINDS. September 30, 2015

  3. Antonina Kouli, K. M. T., & Wei-Li K., (2018) Parkinson’s disease: Pathogenesis and clinical aspects. NIH NLM

  4. Grover, S., et al. (2015). Psychiatric aspects of Parkinson’s disease. Journal of Neurosciences in Rural Practice, 6(1), 65–76.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lubomski, M., Davis, R. L., & Sue, C. M. (2021). Health-related quality of life for Parkinson’s disease patients and their caregivers. Journal of Movement Disorders, 14(1), 42–52.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Lee, J., et al. (2019). Quality of life of caregivers of individuals with Parkinson’s disease. Rehabilitation Nursing, 44(6), 338–348.

    Article  PubMed  Google Scholar 

  7. Bhimani, R. (2014). Understanding the burden on caregivers of people with Parkinson’s: A scoping review of the literature. Rehabilitation Research and Practice, 2014, 718527.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Thieken, F., & van Munster, M. (2021). Deriving implications for care delivery in Parkinson’s disease by co-diagnosing caregivers as invisible patients. Brain Sciences, 11(12), 1629.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. WHO (2023). Parkinson disease

  10. S. Heath, R., MS, & E. Lanier, RN, MS. (2023). Parkinson’s disease and caregiving

  11. Hoffmann & Rodrigues, S. E. A. (2016). The challenging roles of informal carers

  12. Norlin, J. M., Kellerborg, K., Persson, U., Åström, D. O., Hagell, P., Martinez-Martin, P., & Odin, P. (2023). Clinical impression of severity index for Parkinson’s disease and its association to health-related quality of life. Movement Disorders Clinical Practice, 10(3), 392–398.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Afentou, N., et al. (2019). Economic evaluation of interventions in Parkinson’s disease: A systematic literature review. Movement Disorders Clinical Practice, 6(4), 282–290.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Jørgensen, J., Servos, S., & Kefalas, P. (2018). The potential price and access implications of the cost-utility and budget impact methodologies applied by NICE in England and ICER in the US for a novel gene therapy in Parkinson’s disease. J Mark Access Health Policy, 6(1), 1500419.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Liu, X., et al. (2023). An occupational health survey on health utility and occupational diseases in Chinese university staff to inform cost-utility analysis. Frontiers in Public Health. https://doi.org/10.3389/fpubh.2022.1022344

    Article  PubMed  PubMed Central  Google Scholar 

  16. Mar, J., et al. (2023). Cost-utility analysis of the UPRIGHT intervention promoting resilience in adolescents. BMC Psychiatry, 23(1), 178.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Wu, H., et al. (2021). Cost-utility analysis of palliative care in patients with advanced cancer: A retrospective study. BMC Palliative Care, 20(1), 126.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Liberati, A., et al. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Journal of Clinical Epidemiology, 62(10), e1-34.

    Article  PubMed  Google Scholar 

  19. Balestroni, G., & Bertolotti, G. (2012). EuroQol-5D (EQ-5D): An instrument for measuring quality of life. Monaldi Archives for Chest Disease, 78(3), 155–159.

    PubMed  Google Scholar 

  20. Pattanaphesaj, J., & Thavorncharoensap, M. (2015). Measurement properties of the EQ-5D-5L compared to EQ-5D-3L in the Thai diabetes patients. Health and Quality of Life Outcomes, 13, 14.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Claire, M. N., et al. (2016). The EQ-5D-5L health status questionnaire in COPD: Validity, responsiveness and minimum important difference. Thorax, 71(6), 493.

    Article  Google Scholar 

  22. Janssen, M. F., Bonsel, G. J., & Luo, N. (2018). Is EQ-5D-5L better than EQ-5D-3L? A head-to-head comparison of descriptive systems and value sets from seven countries. PharmacoEconomics, 36(6), 675–697.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Moradi, N., et al. (2022). Psychometric properties of the EQ-5D-5L compared with EQ-5D-3L in cancer patients in Iran. Frontiers in Oncology, 12, 1052155.

    Article  PubMed  PubMed Central  Google Scholar 

  24. McCaffrey, N., et al. (2016). Health-related quality of life measured using the EQ-5D–5L: South Australian population norms. Health and Quality of Life Outcomes, 14(1), 133.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Antonini, A., et al. (2015). Global long-term study on motor and non-motor symptoms and safety of levodopa-carbidopa intestinal gel in routine care of advanced Parkinson’s disease patients; 12-month interim outcomes. Parkinsonism & Related Disorders, 21, 231–235.

    Article  Google Scholar 

  26. A’Campo, L. E. I., et al. (2010). The benefits of a standardized patient education program for patients with Parkinson’s disease and their caregivers. Parkinsonism and Related Disorders, 16(2), 89–95.

    Article  PubMed  Google Scholar 

  27. Carter, B., et al. (2021). A single patient reported outcome measure for acquired brain injury, multiple sclerosis & Parkinson’s disease. PloS ONE, 16(6), e0251484.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Balzer-Geldsetzer, M., et al. (2018). Quality of life in a German cohort of Parkinson’s patients assessed with three different measures. Journal of Neurology, 265(11), 2713–2722.

    Article  CAS  PubMed  Google Scholar 

  29. Bettecken, K., et al. (2017). No relevant association of kinematic gait parameters with Health-related Quality of Life in Parkinson’s disease. PLoS ONE. https://doi.org/10.1371/journal.pone.0176816

    Article  PubMed  PubMed Central  Google Scholar 

  30. Bock, M. A., et al. (2022). Association of Motor and nonmotor symptoms with health-related quality of life in a large online cohort of people with Parkinson disease. Neurology, 98(22), E2194–E2203.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Brettschneider, C., et al. (2013). Relative impact of multimorbid chronic conditions on health-related quality of life–results from the MultiCare Cohort Study. PloS ONE, 8(6), e66742.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Cano-de-la-Cuerda, R., et al. (2011). Axial rigidity and quality of life in patients with Parkinson’s disease: A preliminary study. Quality of Life Research, 20(6), 817–823.

    Article  PubMed  Google Scholar 

  33. Morley, D., et al. (2016). Validation of the Oxford participation and activities questionnaire. Patient Related Outcome Measures, 7, 73–80.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Kelly, D. H., et al. (2012). Health-related quality of life and strain in caregivers of Australians with Parkinson’s disease: An observational study. BMC Neurology, 12, 57.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Cubo, E., et al. (2014). Comparison of the clinical profile of Parkinson’s disease between Spanish and Cameroonian cohorts. Journal of the Neurological Sciences, 336, 122–126.

    Article  PubMed  Google Scholar 

  36. Torny, F., et al. (2018). Factors associated with spousal burden in Parkinson’s disease. Revue Neurologique, 174(10), 711–715.

    Article  CAS  PubMed  Google Scholar 

  37. Genc, G., et al. (2016). Socioeconomic status may impact functional outcome of deep brain stimulation surgery in Parkinson’s disease. Neuromodulation: Journal of the International Neuromodulation Society, 19(1), 25–30.

    Article  PubMed  Google Scholar 

  38. Tamás, G., et al. (2014). Quality of life and costs in Parkinson’s disease: a cross sectional study in Hungary. PloS ONE, 9(9), e107704.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Goel, A., Narayan, S. K., & Sugumaran, R. (2022). A telephonic survey of health-related quality of life of outpatient department dropout Parkinson’s disease patients during the COVID-19 pandemic. Acta Neurologica Belgica, 122(2), 519–523.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Grigoriou, S., et al. (2021). Effects of safinamide on pain in patients with fluctuating Parkinson’s disease. Brain and Behavior. https://doi.org/10.1002/brb3.2336

    Article  PubMed  PubMed Central  Google Scholar 

  41. Shin, H., et al. (2012). Caregiver burden in Parkinson disease with dementia compared to Alzheimer disease in Korea. Journal of Geriatric Psychiatry and Neurology, 25(4), 222–226.

    Article  PubMed  Google Scholar 

  42. Horváth, K., et al. (2014). Test-retest validity of Parkinson’s disease sleep scale 2nd version (PDSS-2). Journal of Parkinson’s Disease, 4(4), 687–691.

    Article  PubMed  Google Scholar 

  43. Sturkenboom, I. H., et al. (2015). Economic evaluation of occupational therapy in Parkinson’s disease: A randomized controlled trial. Movement Disorders: Official Journal of the Movement Disorder Society, 30(8), 1059–67.

    Article  PubMed  Google Scholar 

  44. Marinus, J., et al. (2003). A short psychosocial questionnaire for patients with Parkinson’s disease: The SCOPA-PS. Journal of Clinical Epidemiology, 56(1), 61–7.

    Article  PubMed  Google Scholar 

  45. Tollár, J., et al. (2019). Two-year agility maintenance training slows the progression of Parkinsonian symptoms. Medicine and Science in Sports and Exercise, 51(2), 237–245.

    Article  PubMed  Google Scholar 

  46. Tan, L. C. S., et al. (2004). Validity and reliability of the PDQ-39 and the PDQ-8 in English-speaking Parkinson’s disease patients in Singapore. Parkinsonism & Related Disorders, 10(8), 493–9.

    Article  Google Scholar 

  47. Leavy, B., et al. (2020). Outcome evaluation of highly challenging balance training for people with Parkinson disease: A multicenter effectiveness-implementation study. Journal of Neurologic Physical Therapy, 44(1), 15–22.

    Article  PubMed  Google Scholar 

  48. Blandy, L. M., et al. (2015). Therapeutic argentine tango dancing for people with mild Parkinson’s disease: A feasibility study. Frontiers in Neurology, 6, 122.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Pillas, M., et al. (2016). Development and validation of a carers quality-of-life questionnaire for parkinsonism (PQoL carers). Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 25(1), 81–8.

    Article  PubMed  Google Scholar 

  50. Marinus, J., et al. (2008). Evaluation of the Dutch version of the Parkinson’s disease questionnaire 39. Parkinsonism and Related Disorders, 14(1), 24–27.

    Article  PubMed  Google Scholar 

  51. Bianchi, M. L. E., et al. (2019). Efficacy of safinamide on non-motor symptoms in a cohort of patients affected by idiopathic Parkinson’s disease. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 40(2), 275–279.

    Article  PubMed  Google Scholar 

  52. Müller, T., & Woitalla, D. (2010). Quality of life, caregiver burden and insurance in patients with Parkinson’s disease in Germany. European Journal of Neurology, 17(11), 1365–1369.

    Article  PubMed  Google Scholar 

  53. Santos-García, D., et al. (2022). Predictors of the change in burden, strain, mood, and quality of life among caregivers of Parkinson’s disease patients. International Journal of Geriatric Psychiatry. https://doi.org/10.1002/gps.5761Citations

    Article  PubMed  Google Scholar 

  54. Simuni, T., et al. (2013). Rankin scale as a potential measure of global disability in early Parkinson’s disease. Journal of Clinical Neuroscience, 20, 1200–1203.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Thach, A., et al. (2021). Real-world assessment of the impact of “OFF” episodes on health-related quality of life among patients with Parkinson’s disease in the United States. BMC Neurology. https://doi.org/10.1186/s12883-021-02074-2

    Article  PubMed  PubMed Central  Google Scholar 

  56. Zhang, Z., et al. (2018). Adjunct rasagiline to treat Parkinson’s disease with motor fluctuations: A randomized, double-blind study in China. Translational Neurodegeneration, 7, 1–11.

    Google Scholar 

  57. Winter, Y., et al. (2010). Social and clinical determinants of quality of life in Parkinson’s disease in a Russian cohort study. Parkinsonism and Related Disorders, 16(4), 243–248.

    Article  PubMed  Google Scholar 

  58. Tollar, J., Nagy, F., & Hortobágyi, T. (2019). Vastly different exercise programs similarly improve Parkinsonian symptoms: A randomized clinical trial. Gerontology, 65(2), 120–127.

    Article  PubMed  Google Scholar 

  59. Gray, R., et al. (2022). Long-term effectiveness of adjuvant treatment with catechol-o-methyltransferase or monoamine oxidase B inhibitors compared with dopamine agonists among patients with Parkinson disease uncontrolled by levodopa therapy: The PD MED randomized clinical trial. JAMA Neurology, 79(2), 131–140.

    Article  PubMed  Google Scholar 

  60. Acampo, L. E. I., et al. (2010). Caregiver education in Parkinson’s disease: Formative evaluation of a standardized program in seven European countries. Quality of Life Research: An International Journal of Quality Of life Aspects of Treatment, Care and Rehabilitation, 19(1), 55–64.

    Article  CAS  PubMed  Google Scholar 

  61. Luo, N., et al. (2005). Validity and reliability of the Chinese (Singapore) version of the Parkinson’s disease questionnaire (PDQ-39). Quality of Life Research, 14(1), 273–279.

    Article  CAS  PubMed  Google Scholar 

  62. Svetel, M., et al. (2019). Clinical course of patients with pantothenate kinase-associated neurodegeneration (PKAN) before and after DBS surgery. Journal of Neurology, 266(12), 2962–2969.

    Article  CAS  PubMed  Google Scholar 

  63. Matias, C. M., et al. (2018). Deep brain stimulation outcomes in patients implanted under general anesthesia with frame-based stereotaxy and intraoperative MRI. Journal of Neurosurgery, 129(6), 1572–1578.

    Article  PubMed  Google Scholar 

  64. Minar, M., et al. (2022). Restless legs syndrome in Parkinson’s disease: Relationship with quality of life and medication. Bratislava Medical Journal, 123(1), 55–60.

    Article  CAS  PubMed  Google Scholar 

  65. Müller, T., Muhlack, S., & Woitalla, D. (2011). Pain perception, pain drug therapy and health status in patients with Parkinson’s disease. Neuroepidemiology, 37(3), 183–187.

    Article  PubMed  Google Scholar 

  66. Ghislandi, S., et al. (2002). Is EQ-5D a valid measure of HRQoL in patients with movement disorders? A comparison with SF-36 and FIM questionnaires. The European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care, 3(2), 125–130.

    Article  CAS  PubMed  Google Scholar 

  67. Kalampokini, S., et al. (2022). Caregiver burden in late-stage Parkinsonism and its associations. Journal of Geriatric Psychiatry and Neurology, 35(1), 110–120.

    Article  PubMed  Google Scholar 

  68. Schrag, A., et al. (2007). Testing the validity of the PDQ-39 in patients with MSA. Parkinsonism & Related Disorders, 13(3), 152–156.

    Article  CAS  Google Scholar 

  69. Vibha, D., et al. (2011). RBD in Parkinson’s disease: A clinical case control study from North India. Clinical Neurology and Neurosurgery, 113(6), 472–476.

    Article  PubMed  Google Scholar 

  70. Visser, M., et al. (2008). A comprehensive model of health-related quality of life in Parkinson’s disease. Journal of Neurology, 255(10), 1580–1587.

    Article  CAS  PubMed  Google Scholar 

  71. Cano-de-la-Cuerda, R., et al. (2014). Isokinetic dynamometry as a technologic assessment tool for trunk rigidity in Parkinson’s disease patients. NeuroRehabilitation, 35(3), 493–501.

    Article  PubMed  Google Scholar 

  72. Alvarado-Bolaños, A., et al. (2015). Convergent validation of EQ-5D-5L in patients with Parkinson’s disease. Journal of the Neurological Sciences, 358(1), 53–57.

    Article  PubMed  Google Scholar 

  73. Siderowf, A., Ravina, B., & Glick, H. A. (2002). Preference-based quality-of-life in patients with Parkinson’s disease. Neurology, 59(1), 103–108.

    Article  PubMed  Google Scholar 

  74. Abboud, H., et al. (2015). Impact of mild cognitive impairment on outcome following deep brain stimulation surgery for Parkinson’s disease. Parkinsonism & Related Disorders, 21(3), 249–253.

    Article  Google Scholar 

  75. Wojtowicz, A. L., et al. (2019). Is Parkinson’s disease associated with increased mortality, poorer outcomes scores, and revision risk after THA? Findings from the Swedish hip arthroplasty register. Clinical Orthopaedics and Related Research, 477(6), 1347–1355.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Alonso-Morán, E., et al. (2015). Health-related quality of life and multimorbidity in community-dwelling telecare-assisted elders in the Basque Country. European Journal of Internal Medicine, 26(3), 169–175.

    Article  PubMed  Google Scholar 

  77. Bega, D., et al. (2015). Impact of depression on progression of impairment and disability in early Parkinson’s disease. Movement Disorders Clinical Practice, 2(4), 371–378.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Benito-León, J., et al. (2012). Impact of apathy on health-related quality of life in recently diagnosed Parkinson’s disease: The ANIMO study. Movement Disorders, 27(2), 211–218.

    Article  PubMed  Google Scholar 

  79. Beretzky, Z., & Péntek, M. (2017). Characteristics and determinants of informal care in chronic diseases in Hungary: A comparative analysis. Orvosi Hetilap, 158(52), 2068–2078.

    Article  PubMed  Google Scholar 

  80. Bugalho, P., et al. (2021). Progression in Parkinson’s disease: variation in motor and non-motor symptoms severity and predictors of decline in cognition, motor function, disability, and health-related quality of life as assessed by two different methods. Movement Disorders Clinical Practice, 8(6), 885–895.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Chen, G., et al. (2018). Converting Parkinson-specific scores into health state utilities to assess cost-utility analysis. Patient, 11(6), 665–675.

    Article  PubMed  Google Scholar 

  82. Cheung, Y. B., et al. (2008). Mapping the eight-item Parkinson’s disease questionnaire (PDQ-8) to the EQ-5D utility index. Quality of Life Research, 17(9), 1173–1181.

    Article  CAS  PubMed  Google Scholar 

  83. Clarke, C. E., et al. (2016). Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease. JAMA Neurology, 73(3), 291–299.

    Article  PubMed  Google Scholar 

  84. Cubí-Mollá, P., De Vries, J., & Devlin, N. (2014). A study of the relationship between health and subjective well-being in Parkinson’s disease patients. Value Health, 17(4), 372–379.

    Article  PubMed  Google Scholar 

  85. Daley, D. J., et al. (2014). Adherence therapy improves medication adherence and quality of life in people with Parkinson’s disease: A randomised controlled trial. International Journal of Clinical Practice, 68(8), 963–971.

    Article  CAS  PubMed  Google Scholar 

  86. Dzingina, M. D., McCrone, P., & Higginson, I. J. (2017). Does the EQ-5D capture the concerns measured by the Palliative care Outcome Scale? Mapping the Palliative care Outcome Scale onto the EQ-5D using statistical methods. Palliative Medicine, 31(8), 716–725.

    Article  PubMed  Google Scholar 

  87. Emma, M., et al. (2016). Cost-utility analysis of deep brain stimulation surgery plus best medical therapy versus best medical therapy in patients with Parkinson’s: Economic evaluation alongside the PD SURG trial. Movement Disorders, 31, 1173–1182.

    Article  Google Scholar 

  88. Ebersbach, G., et al. (2010). Tolcapone improves sleep in patients with advanced Parkinson’s disease (PD). Archives of Gerontology and Geriatrics, 51(3), e125–e128.

    Article  CAS  PubMed  Google Scholar 

  89. Exuzides, A., et al. (2022). Understanding the burdens associated with Huntington’s disease in manifest patients and care partners-comparing to Parkinson’s disease and the general population. Brain Sciences. https://doi.org/10.3390/brainsci12020161

    Article  PubMed  PubMed Central  Google Scholar 

  90. Fan, X., et al. (2018). Assessment of health-related quality of life between people with Parkinson’s disease and non-Parkinson’s: Using data drawn from the ‘100 for Parkinson’s’ smartphone-based prospective study. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph15112538

    Article  PubMed  PubMed Central  Google Scholar 

  91. Carod-Artal, F. J., Mesquita, H. M., et al. (2013). Burden and health-related quality of life among caregivers of Brazilian Parkinson’s disease patients. Parkinsonism & Related Disorders, 19(11), 943–948.

    Article  Google Scholar 

  92. Carod-Artal, F. J., & Martinez-Martin, P. (2013). Independent validation of the non motor symptoms scale for Parkinson’s disease in Brazilian patients. Parkinsonism & Related Disorders, 19(1), 115–119.

    Article  Google Scholar 

  93. Fletcher, E., Goodwin, V. A., Richards, S. H., Campbell, J. L., & Taylor, R. S. (2012). An exercise intervention to prevent falls in Parkinson’s: an economic evaluation. BMC Health Services Research, 12, 1–9.

    Article  Google Scholar 

  94. Deli, G., et al. (2015). Deep brain stimulation can preserve working status in Parkinson’s disease. Parkinson’s Disease, 2015, 936865.

    PubMed  PubMed Central  Google Scholar 

  95. Nielsen, G., et al. (2017). Randomised feasibility study of physiotherapy for patients with functional motor symptoms. Journal of Neurology, Neurosurgery, and Psychiatry, 88(6), 484–490.

    Article  CAS  PubMed  Google Scholar 

  96. García-Gordillo, M., et al. (2014). Validation and comparison of 15-D and EQ-5D-5L instruments in a Spanish Parkinson’s disease population sample. Quality of Life Research, 23(4), 1315–1326.

    Article  PubMed  Google Scholar 

  97. Hechtner, M. C., et al. (2014). Quality of life in Parkinson’s disease patients with motor fluctuations and dyskinesias in five European countries. Parkinsonism & Related Disorders, 20(9), 969–974.

    Article  Google Scholar 

  98. Hurwitz, B., et al. (2005). Scientific evaluation of community-based Parkinson’s disease nurse specialists on patient outcomes and health care costs. Journal of Evaluation in Clinical Practice, 11(2), 97–110.

    Article  PubMed  Google Scholar 

  99. Jarman, B., et al. (2002). Effects of community based nurses specialising in Parkinson’s disease on health outcome and costs: Randomised controlled trial. British Medical Journal, 324(7345), 1072–1075.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Järvelä, J. T., & Kaasinen, V. (2016). Pharmacotherapy and generic health-related quality of life in Parkinson’s disease. Acta Neurologica Scandinavica, 134(3), 205–209.

    Article  PubMed  Google Scholar 

  101. Johansson, D., et al. (2018). Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry. CNS Neuroscience and Therapeutics, 24(5), 439–447.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Klotsche, J., et al. (2011). Trajectory classes of decline in health-related quality of life in Parkinson’s disease: A pilot study. Value in Health, 14(2), 329–338.

    Article  PubMed  Google Scholar 

  103. Kovács, M., et al. (2016). Impact of sex on the nonmotor symptoms and the health-related quality of life in Parkinson’s disease. Parkinson’s Disease. https://doi.org/10.1155/2016/7951840

    Article  PubMed  PubMed Central  Google Scholar 

  104. Larisch, A., et al. (2011). Does the clinical practice guideline on Parkinson’s disease change health outcomes? A cluster randomized controlled trial. Journal of Neurology, 258(5), 826–834.

    Article  PubMed  Google Scholar 

  105. Luo, N., et al. (2009). Is EQ-5D a valid quality of life instrument in patients with Parkinson’s disease? A study in Singapore. Annals of the Academy of Medicine, Singapore, 38(6), 521–528.

    Article  PubMed  Google Scholar 

  106. Norlin, J., et al. (2022). Quality of life and resource utilization-Swedish data from the care of late-stage Parkinsonism (CLaSP) study. Acta Neurologica Scandinavica, 145(6), 743–752.

    Article  Google Scholar 

  107. Martínez-Martín, P., et al. (2005). Quality of life of caregivers in Parkinson’s disease. Quality of Life Research, 14(2), 463–472.

    Article  PubMed  Google Scholar 

  108. Martínez-Martín, P., et al. (2007). Caregiver burden in Parkinson’s disease. Movement Disorders, 22(7), 924–931.

    Article  PubMed  Google Scholar 

  109. Martinez-Martin, P., et al. (2011). The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’s disease. Movement Disorders, 26(3), 399–406.

    Article  PubMed  Google Scholar 

  110. Martinez-Martin, P., et al. (2017). Distribution and impact on quality of life of the pain modalities assessed by the King’s Parkinson’s disease pain scale. Npj Parkinson’s Disease. https://doi.org/10.1038/s41531-017-0009-1

    Article  PubMed  PubMed Central  Google Scholar 

  111. Martinez-Martin, P., et al. (2008). SCOPA-sleep and PDSS: Two scales for assessment of sleep disorder in Parkinson’s disease. Movement Disorders, 23(12), 1681–1688.

    Article  PubMed  Google Scholar 

  112. Martín-García, S., et al. (2013). Comorbidity, health status, and quality of life in institutionalized older people with and without dementia. International Psychogeriatrics, 25(7), 1077–1084.

    Article  PubMed  Google Scholar 

  113. Nan, L., et al. (2010). Responsiveness of the EQ-5D and 8-item Parkinson’s disease questionnaire (PDQ-8) in a 4-year follow-up study. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 19(4), 565–9.

    Article  Google Scholar 

  114. Paulo, B., et al. (2019). Motor and non-motor function predictors of mortality in Parkinson’s disease. Journal of Neural Transmission, 126(11), 1409–1415.

    Article  Google Scholar 

  115. Raphael, S., et al. (2020). Parkinson’s disease multimodal complex treatment improves motor symptoms, depression and quality of life. Journal of Neurology, 267(4), 954–965.

    Article  Google Scholar 

  116. Reuther, M., et al. (2007). Assessing health-related quality of life in patients with Parkinson’s disease in a prospective longitudinal study. Parkinsonism & Related Disorders, 13(2), 108–114.

    Article  CAS  Google Scholar 

  117. Rodriguez-Blazquez, C., et al. (2010). Independent validation of the scales for outcomes in Parkinson’s disease-autonomic (SCOPA-AUT). European Journal of Neurology, 17(2), 194–201.

    Article  CAS  PubMed  Google Scholar 

  118. Rodriguez-Blazquez, C., et al. (2013). The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson’s disease. Parkinsonism & Related Disorders, 19(10), 889–893.

    Article  Google Scholar 

  119. Seamus, K., et al. (2015). Mapping from the Parkinson’s disease questionnaire PDQ-39 to the generic EuroQol EQ-5D-3L: The value of mixture models. Medical Decision Making: An International Journal of the Society for Medical Decision Making, 35(7), 902–11.

    Article  Google Scholar 

  120. Schrag, A., Jahanshahi, M., & Quinn, N. (2000). How does Parkinson’s disease affect quality of life? A comparison with quality of life in the general population. Movement Disorders, 15(6), 1112–1118.

    Article  CAS  PubMed  Google Scholar 

  121. Schröder, S., et al. (2012). Impact of community pharmaceutical care on patient health and quality of drug treatment in Parkinson’s disease. International Journal of Clinical Pharmacy, 34(5), 746–756.

    Article  PubMed  Google Scholar 

  122. Taylor, P. N., et al. (2021). The effectiveness of peroneal nerve functional electrical simulation for the reduction of bradykinesia in Parkinson’s disease: A feasibility study for a randomised control trial. Clinical Rehabilitation, 35(4), 546–557.

    Article  PubMed  Google Scholar 

  123. Zong, Y., et al. (2022). Quality of life assessment after total knee arthroplasty in patients with Parkinson’s disease. BMC Musculoskeletal Disorders. https://doi.org/10.1186/s12891-022-05176-1

    Article  PubMed  PubMed Central  Google Scholar 

  124. Yang, H.-J., et al. (2014). Comparison of sleep and other non-motor symptoms between SWEDDs patients and de novo Parkinson’s disease patients. Parkinsonism & Related Disorders, 20(12), 1419–1422.

    Article  Google Scholar 

  125. Xiao, R., et al. (2016). Quality of life outcomes following cervical decompression for coexisting Parkinson’s disease and cervical spondylotic myelopathy. Spine Journal, 16(11), 1358–1366.

    Article  Google Scholar 

  126. Deli, G., et al. (2015). Earlier and more efficiently: The role of deep brain stimulation for Parkinson’s disease preserving the working capabilities. Korábban és hatékonyabban: A mély agyi stimuláció szerepe a munkaképesség megorzésében, 68(11), 384–390.

    Google Scholar 

  127. Junaid Farrukh, M., et al. (2021). Medication adherence status among patients with neurological conditions and its association with quality of life. Saudi Pharmaceutical Journal, 29(5), 427–433.

    Article  PubMed  PubMed Central  Google Scholar 

  128. Zrubka, Z., et al. (2019). A comparison of European, Polish, Slovenian and British EQ-5D-3L value sets using a Hungarian sample of 18 chronic diseases. European Journal of Health Economics, 20, 119–132.

    Article  Google Scholar 

  129. Zahra, M., et al. (2020). Parkinson’s disease with early motor complications: Predicting EQ-5D-3L utilities from PDQ-39 data in the EARLYSTIM trial. Health and Quality of Life Outcomes. https://doi.org/10.1186/s12955-020-01299-y

    Article  PubMed  PubMed Central  Google Scholar 

  130. Xin, Y., et al. (2020). Cost-effectiveness of the PDSAFE personalised physiotherapy intervention for fall prevention in Parkinson’s: An economic evaluation alongside a randomised controlled trial. BMC Neurology, 20(1), 295.

    Article  PubMed  PubMed Central  Google Scholar 

  131. Zhu, X. L., Chan, D. T., Lau, C. K., Poon, W. S., Mok, V. C., Chan, A. Y., & Yeung, C. (2014). Cost-effectiveness of subthalmic nucleus deep brain stimulation for the treatment of advanced Parkinson disease in Hong Kong: A prospective study. World neurosurgery, 82(6), 987–993.

    Article  CAS  PubMed  Google Scholar 

  132. Norlin, J. M., Kellerborg, K., & Odin, P. (2021). Patient utilities in health states based on Hoehn and Yahr and off-time in Parkinson’s disease: A Swedish register-based study in 1823 observations. PharmacoEconomics, 39(10), 1141–1149.

    Article  PubMed  Google Scholar 

  133. Noyes, K., Dick, A. W., & Holloway, R. G. (2006). Pramipexole versus levodopa in patients with early Parkinson’s disease: Effect on generic and disease-specific quality of life. Value in Health, 9(1), 28–38.

    Article  PubMed  Google Scholar 

  134. Shearer, J., et al. (2012). The impact of motor and non motor symptoms on health state values in newly diagnosed idiopathic Parkinson’s disease. Journal of Neurology, 259(3), 462–468.

    Article  PubMed  Google Scholar 

  135. Shiroiwa, T., Noto, S., & Fukuda, T. (2021). Japanese population norms of EQ-5D-5L and health utilities index mark 3: Disutility catalog by disease and symptom in community settings. Value Health, 24(8), 1193–1202.

    Article  PubMed  Google Scholar 

  136. Soeteman, D. I., et al. (2005). Assessment of the burden of disease among inpatients in specialized units that provide psychotherapy. Psychiatric Services, 56(9), 1153–1155.

    Article  PubMed  Google Scholar 

  137. Soh, S.-E., et al. (2016). Health-related quality of life in people with Parkinson’s disease receiving comprehensive care. Australian Health Review, 40(6), 613–618.

    Article  PubMed  Google Scholar 

  138. Saarni, S. I., et al. (2006). The impact of 29 chronic conditions on health-related quality of life: A general population survey in Finland using 15D and EQ-5D. Quality of Life Research, 15(8), 1403–1414.

    Article  PubMed  Google Scholar 

  139. Schrag, A., et al. (2000). The EQ-5D—A generic quality of life measure—Is a useful instrument to measure quality of life in patients with Parkinson’s disease. Journal of Neurology Neurosurgery and Psychiatry, 69(1), 67–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  140. Schrag, A., et al. (2009). Comparative responsiveness of Parkinson’s disease scales to change over time. Movement Disorders, 24(6), 813–818.

    Article  PubMed  Google Scholar 

  141. Wade, D. T., et al. (2003). Multidisciplinary rehabilitation for people with Parkinson’s disease: A randomised controlled study. Journal of Neurology, Neurosurgery and Psychiatry, 74(2), 158–162.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  142. Tollár, J., et al. (2018). A high-intensity multicomponent agility intervention improves Parkinson patients’ clinical and motor symptoms. Archives of Physical Medicine and Rehabilitation, 99(12), 2478-2484.e1.

    Article  PubMed  Google Scholar 

  143. Stathis, P., & Papadopoulos, G. (2022). Evaluation and validation of a patient-reported quality-of-life questionnaire for Parkinson’s disease. Journal of Patient-Reported Outcomes, 6(1), 17.

    Article  PubMed  PubMed Central  Google Scholar 

  144. Martinez-Martin, P., Arroyo, S., Rojo-Abuin, J. M., Rodriguez-Blazquez, C., Frades, B., & de Pedro Cuesta, J. (2008). Burden, perceived health status, and mood among caregivers of Parkinson’s disease patients. Movement Disorders: Official Journal of the Movement Disorder Society, 23(12), 1673–1680.

    Article  PubMed  Google Scholar 

  145. Martínez-Martín, P., Rodríguez-Blázquez, C., Forjaz, M. J., Alvarez-Sánchez, M., Arakaki, T., Bergareche-Yarza, A., & Goetz, C. G. (2014). Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson’s disease patients. European Journal of Neurology, 21(3), 519–524.

    Article  PubMed  Google Scholar 

  146. Martinez-Martin, P., Rodriguez-Blazquez, C., Abe, K., Bhattacharyya, K. B., Bloem, B. R., Carod-Artal, F. J., & Chaudhuri, K. R. (2009). International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology, 73(19), 1584–1591.

    Article  CAS  PubMed  Google Scholar 

  147. von Below, D., Wallerstedt, S. M., & Bergquist, F. (2023). Validation of the Swedish patient-reported outcomes in Parkinson’s disease scale in outpatients. Movement Disorders, 38(9), 1668–1678.

    Article  Google Scholar 

  148. Lacy, B., Piotrowski, H. J., Dewey, R. B., Jr., & Husain, M. M. (2023). Severity of depressive and motor symptoms impacts quality of life in Parkinson’s disease patients at an academic movement clinic: A cross-sectional study. Clinical Parkinsonism & Related Disorders, 8, 100180.

    Article  Google Scholar 

  149. Steinle, A. M., Nian, H., Pennings, J. S., Bydon, M., Asher, A., Archer, K. R., & Abtahi, A. M. (2022). Complications, readmissions, revisions, and patient-reported outcomes in patients with Parkinson disease undergoing elective spine surgery: A propensity-matched analysis. Spine, 47(20), 1452–1462.

    Article  PubMed  Google Scholar 

  150. Shiroiwa, T., et al. (2016). Comparison of value set based on DCE and/or TTO data: Scoring for EQ-5D-5L health states in Japan. Value in Health, 19(5), 648–654.

    Article  PubMed  Google Scholar 

  151. Megari, K. (2013). Quality of life in chronic disease patients. Health Psychology Research, 1(3), e27.

    Article  PubMed  PubMed Central  Google Scholar 

  152. Opara, J. A., et al. (2012). Quality of life in Parkinson’s disease. Journal of Medicine and Life, 5(4), 375–381.

    CAS  PubMed  PubMed Central  Google Scholar 

  153. Perlmutter, J. S. (2009). Assessment of Parkinson disease manifestations. Current Protocols in Neuroscience. https://doi.org/10.1002/0471142301.ns1001s49

    Article  PubMed  PubMed Central  Google Scholar 

  154. Zhao, Y. J., et al. (2010). Progression of Parkinson’s disease as evaluated by Hoehn and Yahr stage transition times. Movement Disorders, 25(6), 710–716.

    Article  PubMed  Google Scholar 

  155. Opara, J. A., Brola, W., Leonardi, M., & Błaszczyk, B. (2012). Quality of life in Parkinson’s disease. Journal of Medicine and Life, 5(4), 375–81.

    CAS  PubMed  PubMed Central  Google Scholar 

  156. Mcintosh, C. (2010). Utility scores for comorbid conditions: methodological issues and advances. https://doi.org/10.1007/978-0-387-78665-0_20.

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  1. ICMR-National Institute of Epidemiology, Chennai, India

    Raghu Bhanupriya, Madhumitha Haridoss, Goda Suchitra Lakshmi & Bhavani Shankara Bagepally

  2. Health Technology Assessment Resource Centre ICMR-NIE, ICMR-National Institute of Epidemiology, Ayapakkam, Chennai, 600077, India

    Bhavani Shankara Bagepally

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BPR—Data curation, formal analysis, and original draft. MH—Data curation, formal analysis, inputs on original draft, and reviewing and editing of the manuscript. GS—Data curation. BSB—Conceptualization, Data curation, software, and critical reviewing and editing of the manuscript.

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Bhanupriya, R., Haridoss, M., Lakshmi, G.S. et al. Health-related quality of life in Parkinson’s disease: systematic review and meta-analysis of EuroQol (EQ-5D) utility scores. Qual Life Res (2024). https://doi.org/10.1007/s11136-024-03646-8

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