Aqueous extracts of nettle leaves (100 mg/kg) and greater burdock roots (25 mg/kg) decreased the blood levels of glucose, triglycerides, total cholesterol, and low- and very-low-density lipoproteins; increased the cholesterol and protein contents of high-density lipoproteins; and prevented low-density lipoprotein oxidation and high-density lipoprotein and hemoglobin glycosylation in experimental diabetes mellitus induced in rats by streptozotocin and a high-fat (30%) diet. The hypolipidemic action of the plant extracts did not decrease if the animals were fed a high-fat diet. Rosiglitazone exhibited more significant hypoglycemic and hypolipidemic effects with a low-fat diet. Flavonoids and carotenoids were responsible for the antidiabetic action of the nettle and burdock extracts.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 3, pp. 40 – 44, March, 2019.
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Vengerovskii, A.I., Yakimova, T.V. & Nasanova, O.N. Hypolipidemic Action of Medicinal Plant Extracts for Experimental Diabetes Mellitus. Pharm Chem J 53, 239–242 (2019). https://doi.org/10.1007/s11094-019-01986-1
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DOI: https://doi.org/10.1007/s11094-019-01986-1