We investigated whether indices of the reflex regulation of the cardiovascular system, i.e., muscle ergoreflex activity (ERGO) and characteristics of the autonomic balance, differ from each other while measured in the vertical vs. horizontal positions in healthy humans. Ten young healthy men (mean age 28 ± 1 years; BMI 23.6 ± 0.8 kg/m2) were examined. In each subject, the ERGO (ventilatory response to a control handgrip exercise, with repetitive isometric contractions at 50% of the maximal strength), baroreflex sensitivity (BRS, the sequence method), heart rate variability (HRV), and a few hemodynamic parameters were measured in two positions, horizontal and vertical. In the latter position, the heart rate, and diastolic and mean blood pressures (BP) were higher, while the stroke volume was smaller (all P < 0.05) with no differences in the systolic BP, cardiac output, and systemic vascular resistance (all P > 0.2). The HRV time domains, as well as BRS, decreased, whereas HRV-LF increased (all P < 0.05) in the vertical position as compared to the horizontal one. There were no differences between other HRV parameters (all P > 0.2) in the two examined positions. Minute ventilation during the exercise increased, while ERGO was reduced in the vertical position (all P < 0.05). Thus, the body position noticeably affects both reflex regulation of the cardiovascular system and autonomic balance. This observation has to be taken into account during physiological testing.
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References
S. Schaffner and P. Sabeti, “Evolutionary adaptation in the human lineage,” Nat. Educ., 1, No. 1, 14 (2008).
A. Steptoe and C. Vögele, “Cardiac baroreflex function during postural change assessed using non-invasive spontaneous sequence analysis in young men,” Cardiovasc. Res., 24, No. 8, 627-632 (1990).
P. Ponikowski, T. P. Chua, D. P. Francis, et al., “Muscle ergoreceptor overactivity reflects deterioration in clinical status and cardiorespiratory reflex in chronic heart failure,” Circulation, 104, No. 19, 2324-2330 (2001).
T. A. Bosch, C. L. Kaufman, E. B. Williamson, et al., “Comparison of changes in heart rate variability and blood pressure during nitroglycerin administration and head-up tilt testing,” Clin. Auton. Res., 19, No. 1, 46-50 (2009).
D. W. Eeftinck Schattenkerk, J. J. van Lieshout, A. H. van den Meiracker, et al., “Nexfin noninvasive continuous blood pressure validated against Riva-Rocci/Korotkoff,” Am. J. Hypertens., 22, No. 4, 378-383 (2009).
L. W. Bogert, K. H. Wesseling, O. Schraa, et al., “Pulse contour cardiac output derived from non-invasive arterial pressure in cardiovascular disease,” Anaesthesia, 65, No. 11, 1119-1125 (2010).
M. Sokolski, A. Rydlewska, B. Krakowiak, et al., “Comparison of invasive and non-invasive measurements of haemodynamic parameters in patients with advanced heart failure,” J. Cardiovascul. Med., 12, No. 11, 773-778 (2011).
M. Piepoli, P. Ponikowski, A. L. Clark, et al., “A neural link to explain the “muscle hypothesis” of exercise intolerance in chronic heart failure,” Am. Heart J., 137, No. 6, 1050-1056 (1999).
M. Piepoli, A. L. Clark, M. Volterrani, et al., “Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training,” Circulation, 93, No. 5, 940-952 (1996).
P. Ponikowski, D. P. Francis, M. F. Piepoli, et al., “Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance: marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis,” Circulation, 103, No. 7, 967-972 (2001).
[No authors listed] “Task Force of the European society of cardiology and the North American society of pacing and electrophysiology (1996). Heart rate variability: standards of measurement, physiological interpretation and clinical use,” Circulation, 93, No. 5, 1043-1065 (1996).
P. A. Lanfranchi and V. K. Somers, “Arterial baroreflex function and cardiovascular variability: interactions and implications,” Am. J. Physiol. Regul. Integr. Compar. Physiol., 283, No. 4, 815-826 (2002).
L. C. Davies, D. P. Francis, A. C. Scott, et al., “Effect of altering conditions of the sequence method on baroreflex sensitivity,” J. Hypertens., 19, No. 7, 1279-1287 (2001).
H. Ector, R. Willems, H. Heidbuchel, and T. Reybrouck, “Repeated tilt testing in patients with tilt positive neutrally mediated syncope,” Europace, 7, No. 6, 628-633 (2005).
J. H. Wilmore, D. L. Costill, and W. L. Kenney, Physiology of Sport and Exercise, Human Kinetics, Champaign, IL (2008).
G. Piccirillo, F. Fimognari, E. Viola, and V. Marigliano, “Age-adjusted normal confidence intervals for heart rate variability in healthy subjects during head-up tilt,” Int. J. Cardiol., 50, No. 2, 117-124 (1995).
S. Mukai and J. Hayano, “Heart rate and blood pressure variabilities during graded head-up tilt,” J. Appl. Physiol., 78, No. 1, 212-216 (1995).
S. Palova, J. Havlin, and J. Charvat, “The association of heart rate variability examined in supine and standing position with ambulatory blood pressure monitoring in anorexia nervosa,” Neuroendocrinol. Lett., 33, No. 2, 196-200 (2012).
N. Chenier-Hogan, C. A. Brown, S. M. Hains, and J. L. Parlow. “Heart rate variability response to standing in men and women receiving d,l-sotalol following coronary artery bypass graft surgery,” Biol. Res. Nurs., 14, No. 1, 38-47 (2012).
J. E. Sanderson, L. Y. Yeung, D. T. Yeung, et al., “Impact of changes in respiratory frequency and posture on power spectral analysis of heart rate and systolic blood pressure variability in normal subjects and patients with heart failure,” Clin. Sci., 91, No. 1, 35-43 (1996).
S. J. Brown, M. Bryant, T. Mundel, and S. R. Stannard, “Human ventilatory efficiency and respiratory sinus arrhythmia during head-up tilt,” J. Physiol. Pharmacol., 59, No. 4, 771-780 (2008).
O. Caron, P. Fontanari, J. Cremieux, and F. Joulia, “Effects of ventilation on body sway during human standing,” Neurosci. Lett., 366, No. 1, 6-9 (2004).
M. Egaña and S. Green, “Effect of body tilt on calf muscle performance and blood flow in humans,” J. Appl. Physiol., 98, 2249-2258 (2005).
G. Mancia, G. Grassi, G. Bertinieri, et al., “Arterial baroreceptor control of blood pressure in man,” J. Auton. Nerv. Syst., 11, No. 2, 115-124 (1984).
B. Folkow, U. Haglund, M. Jodal, and O. Lundgren, “Blood flow in the calf muscle of man during heavy rhythmic exercise,” Acta Physiol. Scand., 81, No. 2, 157-163 (1971).
M. H. Laughlin and W. G. Schrage, “Effects of muscle contraction on skeletal muscle blood flow: when is there a muscle pump?” Med. Sci. Sports Exerc., 31, No. 7, 1027-1035 (1999).
D. M. Rotto, C. L. Stebbins, and M. P. Kaufman, “Reflex cardiovascular and ventilatory responses to increasing H+ activity in cat hindlimb muscle,” J. Appl. Physiol., 67, No. 1, 256-263 (1989).
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Siennicka, A., Tkaczyszyn, M., Ludwikowska, K. et al. Muscle Ergoreflex Activity and Autonomic Balance Assessed in the Vertical and Horizontal Body Positions in Young Healthy Men. Neurophysiology 49, 288–294 (2017). https://doi.org/10.1007/s11062-017-9684-0
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DOI: https://doi.org/10.1007/s11062-017-9684-0