We studied the effects of long-lasting treating with cadmium in two different doses (0.1 and 1.0 μg/kg) on the activity of matrix metalloproteinases (MMP2 and MMP9) and metallothionein level in the rat brain. Cadmium in a higher dose (1 μg/kg) caused a decrease in MMP2 activity but increased that of proMMP9 in the brain. The level of MT in the hippocampus and cerebellum dropped with both Cd doses. Thus, even small Cd doses exert specific effects on the MMP activity and MT level in the brain.
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Fomenko, O., Shiyntum, H., Shaulska, O. et al. Effects of Cadmium on the Activity of Matrix Metalloproteinases and Metallothionein Level in the Rat Brain. Neurophysiology 49, 154–157 (2017). https://doi.org/10.1007/s11062-017-9645-7
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DOI: https://doi.org/10.1007/s11062-017-9645-7