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Supratentorial high-grade astrocytoma with leptomeningeal spread to the fourth ventricle: a lethal dissemination with dismal prognosis

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Abstract

Purpose

Leptomeningeal spread to the fourth ventricle (LSFV) from supratentorial high-grade astrocytoma (HGA) is rarely investigated. The incidence and prognostic merit of LSFV were analyzed in this study.

Methods

A consecutive cohort of 175 patients with pathologically diagnosed HGA according to the 2016 WHO classification of brain tumors was enrolled. LSFV was defined as radiological occupation in the fourth ventricle at the moment of initial progression. Clinical, radiological, and pathological data were analyzed to explore the difference between HGA patients with and without LSFV.

Results

There were 18 of 175 (10.3%) HGAs confirmed with LSFV. The difference of survival rate between patients with LSFV or not was significant in both overall survival (OS) (14.5 vs. 24 months, P =  0.0007) and post progression survival (PPS) (6.0 vs. 11.5 months, P = 0.0004), while no significant difference was observed in time to progression (TTP) (8.5 months vs. 9.5 months P = 0.6795). In the Cox multivariate analysis, LSFV was confirmed as an independent prognostic risk factor for OS (HR 2.06, P = 0.010). LSFV was correlated with younger age (P = 0.044), ventricle infringement of primary tumor (P < 0.001) and higher Ki-67 index (P = 0.013) in further analysis, and the latter two have been validated in the Logistic regression analysis (OR 18.16, P = 0.006; OR 4.04, P = 0.012, respectively).

Conclusion

LSFV was indicative of end-stage for supratentorial HGA patients, which shortened patients’ PPS and OS instead of TTP. It’s never too cautious to alert this lethal event when tumor harbored ventricle infringement and higher Ki-67 index in routine clinical course.

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Acknowledgements

It’s extremely precious that the patients rigorously performed every follow-up in our department, which provided us accurate materials for this analysis. The authors sincerely thank the patients and their families for their participation in the present study.

Funding

This study was funded by National Natural Science Foundation of China (81571632).

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Mingxiao Li, Xiaohui Ren, Haihui Jiang, Kaiyuan Yang, Wei Huang, Yong Cui & Song Lin

  2. Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Kefu Yu

  3. Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Hongyan Chen

  4. Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Gehong Dong

  5. National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, 100070, China

    Gehong Dong & Song Lin

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  1. Mingxiao Li
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  2. Xiaohui Ren
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  3. Haihui Jiang
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  9. Yong Cui
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  10. Song Lin
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Correspondence to Song Lin.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Capital Medical University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Li, M., Ren, X., Jiang, H. et al. Supratentorial high-grade astrocytoma with leptomeningeal spread to the fourth ventricle: a lethal dissemination with dismal prognosis. J Neurooncol 142, 253–261 (2019). https://doi.org/10.1007/s11060-018-03086-8

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  • DOI: https://doi.org/10.1007/s11060-018-03086-8

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