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Role of 18F-FDG PET/CT for predicting bone marrow involvement, disease relapse and histopathological transformation in follicular lymphoma—a single centre observation

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Abstract

The objective of present study is to assess the role of the [18Fluorine] 2-Fluoro-2-Deoxy-D-Glucose Positron-Emission-Tomography Computed-Tomography (18F-FDG PET/CT) scan to detect the bone marrow involvement, predict disease free interval (DFI) and histopathological Transformation (HT) in Follicular Lymphoma (FL). Sixty patients were evaluated. Staging 18F-FDG PET/CT scan showed poor sensitivity for bone marrow involvement. Thus, staging 18F-FDG PET/CT cannot replace initial bone marrow biopsy in FL. Maximum standardized uptake value (SUVmax) of lymphomatous lesions in staging 18F-FDG PET/CT scan has no correlation with DFI and HT. Treatment response based on 5-point Deauville Score (5PDS) of interim 18F-FDG PET/CT scan is significantly associated with DFI. Interim 18F-FDG PET/CT scan plays an important role in deciding treatment modification in FL to prevent future recurrence.

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Authors and Affiliations

  1. School of Medical Science and Technology, IIT Kharagpur, Kharagpur, West Bengal, 721302, India

    Sayan Das

  2. Department of Nuclear Medicine, Tata Medical Center, Kolkata, West Bengal, 700160, India

    Raju Gupta, Jayanta Das & Soumendranath Ray

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  1. Sayan Das
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  2. Raju Gupta
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  3. Jayanta Das
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Correspondence to Sayan Das.

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Das, S., Gupta, R., Das, J. et al. Role of 18F-FDG PET/CT for predicting bone marrow involvement, disease relapse and histopathological transformation in follicular lymphoma—a single centre observation. J Radioanal Nucl Chem 333, 1627–1632 (2024). https://doi.org/10.1007/s10967-024-09359-z

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  • DOI: https://doi.org/10.1007/s10967-024-09359-z

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