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In vitro behaviour of three biocompatible glasses in composite implants

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Abstract

Poly(l,dl-lactide) composites containing filler particles of bioactive glasses 45S5 and S53P4 were compared with a composite containing a slowly dissolving glass S68. The in vitro reactivity of the composites was studied in simulated body fluid, Tris-buffered solution, and phosphate buffered saline. The high processing temperature induced thermal degradation giving cavities in the composites containing 45S5 and S53P4, while good adhesion of S68 to the polymer was observed. The cavities partly affected the in vitro reactivity of the composites. The degradation of the composites containing the bioactive glasses was faster in phosphate buffered saline than in the two other solutions. Hydroxyapatite precipitation suggesting bone tissue bonding capability was observed on these two composites in all three solutions. The slower dissolution of S68 glass particles and the limited hydroxyapatite precipitation suggested that this glass has potential as a reinforcing composition with the capability to guide bone tissue growth in biodegradable polymer composites.

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Acknowledgments

This work is part of the activities of the Åbo Akademi Process Chemistry Centre, A National Centre of Excellence by the Academy of Finland.

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Authors and Affiliations

  1. Process Chemistry Centre, Åbo Akademi University, 20500, Turku, Finland

    Leena Varila, Mikko Hupa & Leena Hupa

  2. Vivoxid Ltd, 20750, Turku, Finland

    Timo Lehtonen & Jukka Tuominen

Authors
  1. Leena Varila
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  2. Timo Lehtonen
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  3. Jukka Tuominen
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  4. Mikko Hupa
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  5. Leena Hupa
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Correspondence to Leena Hupa.

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Varila, L., Lehtonen, T., Tuominen, J. et al. In vitro behaviour of three biocompatible glasses in composite implants. J Mater Sci: Mater Med 23, 2425–2435 (2012). https://doi.org/10.1007/s10856-012-4693-4

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  • DOI: https://doi.org/10.1007/s10856-012-4693-4

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