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Likelihood of achieving a 50%, 60%, or 70% estimated live birth rate threshold with 1 or 2 cycles of planned oocyte cryopreservation

  • Assisted Reproduction Technologies
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Abstract

Purpose

To characterize the likelihood of cryopreserving enough oocytes for 50%, 60%, or 70% estimated live birth rate (eLBR) with 1–2 planned oocyte cryopreservation (Pl-OC) cycles.

Methods

We performed a retrospective cohort study utilizing all patients completing ≥ 1 Pl-OC cycle from 2016 to 2018 at a large single-center OC program. Subjects were categorized by age at retrieval and number of cycles. We extrapolated age-based oocyte thresholds for 50%, 60%, or 70% eLBR from previously published data. We calculated the proportion of subjects overall, and for each age group, whose number of frozen oocytes was greater than or equal to their age-based threshold for a 50%, 60%, or 70% eLBR after 1 and 2 cycles. OR for 60% eLBR with one cycle was calculated for age and AMH cutoff values and corroborated with logistic regression.

Results

A total of 1241 subjects, completing 1799 Pl-OC cycles, were included. With one cycle, 66% (819/1241) achieved ≥ 50% eLBR and 51% (634/1241) achieved 70% eLBR. With two cycles, 79.6% (988/1241) attained ≥ 50% eLBR and 65.5% (813/1241) achieved 70% eLBR. Achieving 50%, 60%, or 70% eLBR with 1–2 cycles was significantly associated with both age (p < 0.001) and AMH (p < 0.001). Age < 37.5 and AMH > 1.995 were independently associated with attaining 60% eLBR with one cycle (age: OR 13.73; 95%CI 9.16–20.57, p < 0.001; AMH: OR 7.32; 95% CI 5.50–9.76, p < 0.001).

Conclusions

Younger age and higher AMH were associated with achieving 50%, 60%, or 70% eLBR thresholds with Pl-OC. Nevertheless, almost all subjects were successfully able to preserve enough oocytes for ≥ 50% eLBR in 1–2 cycles.

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Authors and Affiliations

  1. Extend Fertility Medical Practice – Center for Fertility Research and Education, 200 West 57th Street – Suite 1101, New York, NY, 10019, USA

    Bat-Sheva L. Maslow, Michael M. Guarnaccia, Leslie Ramirez & Joshua U. Klein

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  1. Bat-Sheva L. Maslow
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  2. Michael M. Guarnaccia
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  3. Leslie Ramirez
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Correspondence to Bat-Sheva L. Maslow.

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Supplementary Figure 1

ROC curve for AMH levels achieving a 60% eLBR with first cycle. AUC 0.80 (95% CI 0.77–0.82, p < 0.001). Youden’s J-index analysis yielded AMH 1.995 as best cutoff for prediction of achieving 60% eLBR in first cycle. (DOCX 33 kb).

Supplementary Fig. 2

ROC curve for age as a predictor of achieving a 60% eLBR with first cycle. AUC 0.74 (95% CI 0.71–0.77, p < 0.001). Youden’s J-index analysis yielded 37.5 year as best age cutoff for prediction of achieving 60% eLBR in first cycle (DOCX 49 kb) (DOCX 29 kb).

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Maslow, BS.L., Guarnaccia, M.M., Ramirez, L. et al. Likelihood of achieving a 50%, 60%, or 70% estimated live birth rate threshold with 1 or 2 cycles of planned oocyte cryopreservation. J Assist Reprod Genet 37, 1637–1643 (2020). https://doi.org/10.1007/s10815-020-01791-w

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  • DOI: https://doi.org/10.1007/s10815-020-01791-w

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