Skip to main content

Advertisement

SpringerLink
Log in

Stem cell-based therapies for heart failure management: a narrative review of current evidence and future perspectives

  • Published:
Heart Failure Reviews Aims and scope Submit manuscript

Abstract

Heart failure (HF) is a prevalent and debilitating global cardiovascular condition affecting around 64 million individuals, placing significant strain on healthcare systems and diminishing patients’ quality of life. The escalating prevalence of HF underscores the urgent need for innovative therapeutic approaches that target the root causes and aim to restore normal cardiac function. Stem cell-based therapies have emerged as promising candidates, representing a fundamental departure from conventional treatments focused primarily on symptom management. This review explores the evolving landscape of stem cell-based therapies for HF management. It delves into the mechanisms of action, clinical evidence from both positive and negative outcomes, ethical considerations, and regulatory challenges. Key findings include the potential for improved cardiac function, enhanced quality of life, and long-term benefits associated with stem cell therapies. However, adverse events and patient vulnerabilities necessitate stringent safety assessments. Future directions in stem cell-based HF therapies include enhancing efficacy and safety through optimized stem cell types, delivery techniques, dosing strategies, and long-term safety assessments. Personalized medicine, combining therapies, addressing ethical and regulatory challenges, and expanding access while reducing costs are crucial aspects of the evolving landscape.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Rheault-Henry M, White I, Grover D, Atoui R (2021) Stem cell therapy for heart failure: medical breakthrough, or dead end? World J Stem Cells 13(4):236–259. https://doi.org/10.4252/wjsc.v13.i4.236

    Article  PubMed  PubMed Central  Google Scholar 

  2. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Yancy CW (2022) 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145(18):e895–e1032. https://doi.org/10.1161/CIR.0000000000001063

    Article  PubMed  Google Scholar 

  3. Yau TM, Pagani FD, Mancini DM, Chang HL, Lala A, Woo YJ, Acker MA, Selzman CH, Soltesz EG, Kern JA, Maltais S, Charbonneau E, Pan S, Marks ME, Moquete EG, O’Sullivan KL, Taddei-Peters WC, McGowan LK, Green C, Rose EA, Network Cardiothoracic Surgical Trials (2019) Intramyocardial injection of mesenchymal precursor cells and successful temporary weaning from left ventricular assist device support in patients with advanced heart failure: a randomized clinical trial. JAMA 321(12):1176–1186. https://doi.org/10.1001/jama.2019.2341

    Article  PubMed  PubMed Central  Google Scholar 

  4. Poomani MS, Mariappan I, Perumal R, Regurajan R, Muthan K, Subramanian V (2022) Mesenchymal stem cell (mscs) therapy for ischemic heart disease: a promising frontier. Glob Heart 17(1):19. https://doi.org/10.5334/gh.1098

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kishino Y, Fukuda K (2023) Unlocking the pragmatic potential of regenerative therapies in heart failure with next-generation treatments. Biomedicines 11(3):915. https://doi.org/10.3390/biomedicines11030915

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Goldman S, Traverse JH, Zile MR, Juneman E, Greenberg B, Kelly RF, Koevary JW, Lancaster JJ (2022) Perspective on the development of a bioengineered patch to treat heart failure: rationale and proposed design of phase I clinical trial. Vessel Plus 6:54

    Article  CAS  Google Scholar 

  7. Dameshek W (1957) Bone marrow transplantation—a present-day challenge. Blood 12(4):321–323

    Article  CAS  PubMed  Google Scholar 

  8. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B et al (2001) Bone marrow cells regenerate infarcted myocardium. Nature 410(6829)701–5. 2001 Apr 5 [cited 2023 Aug 27]. Available from: https://www.nature.com/articles/35070587

  9. Yagyu T, Yasuda S, Nagaya N, Doi K, Nakatani T, Satomi K, Shimizu W, Kusano K, Anzai T, Noguchi T, Ohgushi H, Kitamura S, Kangawa K, Ogawa H (2019) Long-term results of intracardiac mesenchymal stem cell transplantation in patients with cardiomyopathy. Circ J 83(7):1590–1599. https://doi.org/10.1253/circj.CJ-18-1179

    Article  CAS  PubMed  Google Scholar 

  10. Asahara T, Murohara T, Sullivan A, Silver M, Van Der Zee R, Li T et al (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275(5302):964–7. Feb 14 [cited 2023 Aug 27]. Available from: https://pubmed.ncbi.nlm.nih.gov/9020076/

  11. Menasché P, Vanneaux V, Hagège A, Bel A, Cholley B, Parouchev A, Cacciapuoti I, Al-Daccak R, Benhamouda N, Blons H, Agbulut O, Tosca L, Trouvin JH, Fabreguettes JR, Bellamy V, Charron D, Tartour E, Tachdjian G, Desnos M, Larghero J (2018) Transplantation of human embryonic stem cell-derived cardiovascular progenitors for severe ischemic left ventricular dysfunction. J Am Coll Cardiol 71(4):429–438. https://doi.org/10.1016/j.jacc.2017.11.047

    Article  PubMed  Google Scholar 

  12. Mathiasen AB, Qayyum AA, Jørgensen E, Helqvist S, Kofoed KF, Haack-Sørensen M et al (2020) Bone marrow-derived mesenchymal stromal cell treatment in patients with ischaemic heart failure: final 4-year follow-up of the MSC-HF trial. Eur J Heart Fail 22(5):884–92. May 1 [cited 2023 Aug 28]. Available from: https://pubmed.ncbi.nlm.nih.gov/31863561/

  13. Strauer BE, Yousef M, Schannwell CM (2010) The acute and long-term effects of intracoronary stem cell transplantation in 191 patients with chronic heARt failure: the STAR-heart study. Eur J Heart Fail 12(7):721–9. Jul 1 [cited 2023 Aug 28]. Available from: https://doi.org/10.1093/eurjhf/hfq095

  14. Frljak S, Jaklic M, Zemljic G, Cerar A, Poglajen G, Vrtovec B (2018) CD34+ cell transplantation improves right ventricular function in patients with nonischemic dilated cardiomyopathy. Stem Cells Transl Med 7(2):168–172. https://doi.org/10.1002/sctm.17-0197

  15. Mostafavian Z, Vakilian F, Torkmanzade L, Moghiman T (2018) Effect of stem cell therapy on patients’ quality of life in heart failure with reduced ejection fraction. J Med Life 11(4):359–364. https://doi.org/10.25122/jml-2018-0013

  16. Soetisna TW, Thamrin AMH, Permadijana D, Ramadhani ANE, Sugisman, Santoso A, Mansyur M (2023) Intramyocardial stem cell transplantation during coronary artery bypass surgery safely improves cardiac function: meta-analysis of 20 randomized clinical trials. J Clin Med 12(13). https://doi.org/10.3390/jcm12134430

  17. Raval AN, Johnston PV, Duckers HJ, Cook TD, Traverse JH, Altman PA, Dhingra R, Hematti P, Borrello I, Anderson RD, Pepine CJ (2021) Point of care, bone marrow mononuclear cell therapy in ischemic heart failure patients personalized for cell potency: 12-month feasibility results from CardiAMP heart failure roll-in cohort. Int J Cardiol 326:131–138. https://doi.org/10.1016/j.ijcard.2020.10.043

    Article  PubMed  Google Scholar 

  18. Arrell DK, Rosenow CS, Yamada S, Behfar A, Terzic A. ARTICLE Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome. [cited 2023 Aug 28]; Available from: https://doi.org/10.1038/s41536-020-0091-6

  19. Behfar A, Yamada S, Crespo-Diaz R, Nesbitt JJ, Rowe LA, Perez-Terzic C et al (2010) Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction. J Am Coll Cardiol 56(9):721–34 Aug 24 [cited 2023 Aug 28]. Available from: https://pubmed.ncbi.nlm.nih.gov/20723802/

  20. Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J et al (2013) Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. J Am Coll Cardiol 61(23):2329–38

  21. Bartunek J, Terzic A, Davison BA, Filippatos GS, Radovanovic S, Beleslin B, Merkely B, Musialek P, Wojakowski W, Andreka P, Horvath IG, Katz A, Dolatabadi D, El Nakadi B, Arandjelovic A, Edes I, Seferovic PM, Obradovic S, Vanderheyden M, Jagic N, Program CHART (2017) Cardiopoietic cell therapy for advanced ischaemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial. Eur Heart J 38(9):648–660. https://doi.org/10.1093/eurheartj/ehw543

    Article  CAS  PubMed  Google Scholar 

  22. Ginis I, Luo Y, Miura T, Thies S, Brandenberger R, Gerecht-Nir S et al (2004) Differences between human and mouse embryonic stem cells. Dev Biol 269(2):360–80. May 15 [cited 2023 Aug 28]. Available from: https://pubmed.ncbi.nlm.nih.gov/15110706/

  23. Zeng X, Miura T, Luo Y, Bhattacharya B, Condie B, Chen J et al (2004) Properties of pluripotent human embryonic stem cells BG01 and BG02. Stem Cells 22(3):292–312

    Article  CAS  PubMed  Google Scholar 

  24. Yamada S, Nelson TJ, Crespo-Diaz RJ, Perez-Terzic C, Liu XK, Miki T et al (2008) Embryonic stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells 26(10):2644–53. Oct 1 [cited 2023 Aug 28]. Available from: https://doi.org/10.1634/stemcells.2008-0187

  25. Haider HK, Tan ACK, Aziz S, Chachques JC, Sim EKW (2004) Myoblast transplantation for cardiac repair: a clinical perspective. Mol Ther 9(1):14–23. [cited 2023 Aug 28]. Available from: https://pubmed.ncbi.nlm.nih.gov/14741773/

  26. Marelli D, Desrosiers C, El-Alfy M, Kao RL, Chiu RCJ (1992) Cell transplantation for myocardial repair: an experimental approach. Cell Transplant 1(6):383–90. [cited 2023 Aug 28]. Available from: https://pubmed.ncbi.nlm.nih.gov/1344311/

  27. Sim EKW, Jiang S, Ye L, Lim YL, Ooi OC, Haider KH (2003) Skeletal myoblast transplant in heart failure. J Card Surg 18(4):319–27. Jul 1 [cited 2023 Aug 28]. Available from: https://doi.org/10.1046/j.1540-8191.2003.02033.x

  28. Iseoka H, Miyagawa S, Saito A, Harada A, Sawa Y (2020) Role and therapeutic effects of skeletal muscle-derived non-myogenic cells in a rat myocardial infarction model. Stem Cell Res Ther 11(1):1–10. Feb 18 [cited 2023 Aug 28]. Available from: https://doi.org/10.1186/s13287-020-1582-5

  29. Reffelmann T, Kloner RA. Cellular cardiomyoplasty - cardiomyocytes, skeletal myoblasts, or stem cells for regenerating myocardium and treatment of heart failure? Cardiovasc Res [Internet]. 2003 May 1 [cited 2023 Aug 28];58(2):358–68. Available from: https://doi.org/10.1016/S0008-6363(02)00739-3

  30. Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Pu WT (2015) Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res 116(1):35–45

    Article  CAS  PubMed  Google Scholar 

  31. Sart S, Ma T, Li Y (2014) Preconditioning stem cells for in vivo delivery. BioResearch open access 3(4):137–149

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Abdelwahid E, Kalvelyte A, Stulpinas A, De Carvalho KAT, Guarita-Souza LC, Foldes G (2016) Stem cell death and survival in heart regeneration and repair. Apoptosis 21:252–268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. McDonald GT, Sullivan R, Paré GC, Graham CH (2010) Inhibition of phosphatidylinositol 3-kinase promotes tumor cell resistance to chemotherapeutic agents via a mechanism involving delay in cell cycle progression. Exp Cell Res 316(19):3197–3206

    Article  CAS  PubMed  Google Scholar 

  34. Chen M, Bi LL, Wang ZQ, Zhao F, Gan XD, Wang YG (2013) Time-dependent regulation of neuregulin-1β/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells. Mol Cell Biochem 380:67–72

    Article  CAS  PubMed  Google Scholar 

  35. Matsuura K, Masuda S, Shimizu T (2014) Cell sheet-based cardiac tissue engineering. Anat Rec 297(1):65–72

    Article  CAS  Google Scholar 

  36. Tano N, Kaneko M, Ichihara Y, Ikebe C, Coppen SR, Shiraishi M, Suzuki K (2016) Allogeneic mesenchymal stromal cells transplanted onto the heart surface achieve therapeutic myocardial repair despite immunologic responses in rats. J Am Heart Assoc 5(2):e002815

    Article  PubMed  PubMed Central  Google Scholar 

  37. ​Li, T. S., Cheng, K., Malliaras, K., Smith, R. R., Zhang, Y., Sun, B., … & Marbán, E. (2012) Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol 59(10):942–953

    Article  PubMed  Google Scholar 

  38. Liu ML, Nagai T, Tokunaga M, Iwanaga K, Matsuura K, Takahashi T, Kobayashi Y (2014) Anti-inflammatory peptides from cardiac progenitors ameliorate dysfunction after myocardial infarction. J Am Heart Assoc 3(6):e001101

    Article  PubMed  PubMed Central  Google Scholar 

  39. Vishwakarma A, Bhise NS, Evangelista MB, Rouwkema J, Dokmeci MR, Ghaemmaghami AM, Khademhosseini A (2016) Engineering immunomodulatory biomaterials to tune the inflammatory response. Trends Biotechnol 34(6):470–482

    Article  CAS  PubMed  Google Scholar 

  40. Aurora AB, Porrello ER, Tan W, Mahmoud AI, Hill JA, Bassel-Duby R, Olson EN (2014) Macrophages are required for neonatal heart regeneration. J Clin Investig 124(3):1382–1392

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Madonna R, Van Laake LW, Botker HE, Davidson SM, De Caterina R, Engel FB, Sluijter JP (2019) ESC Working Group on Cellular Biology of the Heart: position paper for cardiovascular research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure. Cardiovasc Res 115(3):488–500

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Heidt T, Courties G, Dutta P, Sager HB, Sebas M, Iwamoto Y, Nahrendorf M (2014) Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction. Circ Res 115(2):284–295

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Epstein JA (2015) Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science 348(6242):aaa6071

  44. Guo R, Morimatsu M, Feng T, Lan F, Chang D, Wan F, Ling Y (2020) Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction. Stem Cell Res Ther 11:1–13

    Article  Google Scholar 

  45. Lee CI, Perng JH, Chen HY, Hong YR, Wang JJ (2015) Undifferentiated neuroblastoma cells are more sensitive to photogenerated oxidative stress than differentiated cells. J Cell Biochem 116:2074–2085. https://doi.org/10.1002/jcb.25165

    Article  CAS  PubMed  Google Scholar 

  46. Willerson JT (2013) Transplantation of mesenchymal cells rejuvenated by the overexpression of telomerase and myocardin promotes revascularization and tissue repair in a murine model of hindlimb ischemia. Circ Res 113(7):902–914

    Article  PubMed  Google Scholar 

  47. Dergilev K, Tsokolaeva Z, Makarevich P, Beloglazova I, Zubkova E, Boldyreva M, Parfyonova Y (2018) C-kit cardiac progenitor cell based cell sheet improves vascularization and attenuates cardiac remodeling following myocardial infarction in rats. BioMed Res Int

  48. Patel AN, Mittal S, Turan G, Winters AA, Henry TD, Ince H, Trehan N (2015) REVIVE trial: retrograde delivery of autologous bone marrow in patients with heart failure. Stem Cells Transl Med 4(9):1021–1027. https://doi.org/10.5966/sctm.2015-0070

    Article  PubMed  PubMed Central  Google Scholar 

  49. Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, Weinstein JN, Kamińska B, Huelsken J, Omberg L, Gevaert O, Colaprico A, Czerwińska P, Mazurek S, Mishra L, Heyn H, Krasnitz A, Godwin AK, Lazar AJ, Cancer Genome Atlas Research Network, Stuart JM, Wiznerowicz M (2018) Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell 173(2):338–354.e15. https://doi.org/10.1016/j.cell.2018.03.034

  50. Bartolucci J, Verdugo FJ, González PL, Larrea RE, Abarzua E, Goset C, Rojo P, Palma I, Lamich R, Pedreros PA, Valdivia G, Lopez VM, Nazzal C, Alcayaga-Miranda F, Cuenca J, Brobeck MJ, Patel AN, Figueroa FE, Khoury M (2017) Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: a phase 1/2 randomized controlled trial (RIMECARD trial [randomized clinical trial of intravenous infusion umbilical cord mesenchymal stem cells on cardiopathy]). Circ Res 121(10):1192–1204. https://doi.org/10.1161/CIRCRESAHA.117.310712

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Gwizdala A, Rozwadowska N, Kolanowski TJ, Malcher A, Cieplucha A, Perek B, Seniuk W, Straburzynska-Migaj E, Oko-Sarnowska Z, Cholewinski W, Michalak M, Grajek S, Kurpisz M (2017) Safety, feasibility and effectiveness of first in-human administration of muscle-derived stem/progenitor cells modified with connexin-43 gene for treatment of advanced chronic heart failure. Eur J Heart Fail 19(1):148–157. https://doi.org/10.1002/ejhf.700

    Article  CAS  PubMed  Google Scholar 

  52. Martino H, Brofman P, Greco O, Bueno R, Bodanese L, Clausell N, Maldonado JA, Mill J, Braile D, Moraes J, Jr Silva S, Bozza A, Santos B, Campos de Carvalho A, Dilated Cardiomyopathy Arm of the MiHeart Study Investigators (2015) Multicenter, randomized, double-blind trial of intracoronary autologous mononuclear bone marrow cell injection in non-ischaemic dilated cardiomyopathy (the dilated cardiomyopathy arm of the MiHeart study). Eur Heart J 36(42):2898–2904. https://doi.org/10.1093/eurheartj/ehv477

  53. Mozid A, Yeo C, Arnous S, Ako E, Saunders N, Locca D, Brookman P, Archbold RA, Rothman M, Mills P, Agrawal S, Martin J, Mathur A (2014) Safety and feasibility of intramyocardial versus intracoronary delivery of autologous cell therapy in advanced heart failure: the REGENERATE-IHD pilot study. Regen Med 9(3):269–278. https://doi.org/10.2217/rme.14.3

    Article  CAS  PubMed  Google Scholar 

  54. Hamshere S, Arnous S, Choudhury T, Choudry F, Mozid A, Yeo C, Barrett C, Saunders N, Gulati A, Knight C, Locca D, Davies C, Cowie MR, Prasad S, Parmar M, Agrawal S, Jones D, Martin J, McKenna W, Mathur A (2015) Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: the REGENERATE-DCM clinical trial. Eur Heart J 36(44):3061–3069. https://doi.org/10.1093/eurheartj/ehv390

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Zhao C, Zhang L, Kong W, Liang J, Xu X, Wu H, Feng X, Hua B, Wang H, Sun L (2015) Umbilical cord-derived mesenchymal stem cells inhibit cadherin-11 expression by fibroblast-like synoviocytes in rheumatoid arthritis. J Immunol Res 2015:137695. https://doi.org/10.1155/2015/137695

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Makkar RR, Kereiakes DJ, Aguirre F, Kowalchuk G, Chakravarty T, Malliaras K, Francis GS, Povsic TJ, Schatz R, Traverse JH, Pogoda JM, Smith RR, Marbán L, Ascheim DD, Ostovaneh MR, Lima JAC, DeMaria A, Marbán E, Henry TD (2020) Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial. Eur Heart J 41(36):3451–3458. https://doi.org/10.1093/eurheartj/ehaa541

    Article  CAS  PubMed  Google Scholar 

  57. Sawa Y, Yoshikawa Y, Toda K, Fukushima S, Yamazaki K, Ono M, Sakata Y, Hagiwara N, Kinugawa K, Miyagawa S (2015) Safety and efficacy of autologous skeletal myoblast sheets (TCD-51073) for the treatment of severe chronic heart failure due to ischemic heart disease. Circ J 79(5):991–999. https://doi.org/10.1253/circj.CJ-15-0243

    Article  PubMed  Google Scholar 

  58. Qayyum AA, van Klarenbosch B, Frljak S, Cerar A, Poglajen G, Traxler-Weidenauer D, Nadrowski P, Paitazoglou C, Vrtovec B, Bergmann MW, Chamuleau SAJ, Wojakowski W, Gyöngyösi M, Kraaijeveld A, Hansen KS, Vrangbaek K, Jørgensen E, Helqvist S, Joshi FR, Johansen EM, Investigators SCIENCE (2023) Effect of allogeneic adipose tissue-derived mesenchymal stromal cell treatment in chronic ischaemic heart failure with reduced ejection fraction - the SCIENCE trial. Eur J Heart Fail 25(4):576–587. https://doi.org/10.1002/ejhf.2772

    Article  CAS  PubMed  Google Scholar 

  59. Fernández-Avilés F, Sanz-Ruiz R, Bogaert J, Casado Plasencia A, Gilaberte I, Belmans A, Fernández-Santos ME, Charron D, Mulet M, Yotti R, Palacios I, Luque M, Sádaba R, San Román JA, Larman M, Sánchez PL, Sanchís J, Jiménez MF, Claus P, Al-Daccak R, Janssens S (2018) Safety and efficacy of intracoronary infusion of allogeneic human cardiac stem cells in patients with ST-segment elevation myocardial infarction and left ventricular dysfunction. Circ Res 123(5):579–589. https://doi.org/10.1161/CIRCRESAHA.118.312823

    Article  CAS  PubMed  Google Scholar 

  60. Hare JM, Fishman JE, Gerstenblith G, DiFede Velazquez DL, Zambrano JP, Suncion VY, Tracy M, Ghersin E, Johnston PV, Brinker JA, Breton E, Davis-Sproul J, Schulman IH, Byrnes J, Mendizabal AM, Lowery MH, Rouy D, Altman P, Foo WP, Ruiz P, Lardo A (2012) Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA 308(22):2369–2379. https://doi.org/10.1001/jama.2012.25321

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Soetisna TW (2021) CD133+ stem cell therapy effects on myocardial regeneration through increased vascular endothelial growth factor correlate with cardiac magnetic resonance imaging results in coronary artery bypass graft surgery patients with low ejection fraction. Heart Surg Forum 24(4):E670–E674. https://doi.org/10.1532/hsf.3763

    Article  PubMed  Google Scholar 

  62. Poglajen G, Frljak S, Zemljič G et al (2020) Stem cell therapy for chronic and advanced heart failure. Curr Heart Fail Rep 17:261–270. https://doi.org/10.1007/s11897-020-00477-9

    Article  PubMed  Google Scholar 

  63. Bolli R, Solankhi M, Tang XL, Kahlon A (2022) Cell therapy in patients with heart failure: a comprehensive review and emerging concepts. Cardiovasc Res 118(4):951–976. https://doi.org/10.1093/cvr/cvab135

    Article  CAS  PubMed  Google Scholar 

  64. Aly RM (2020) Current state of stem cell-based therapies: an overview. Stem Cell Investig 7:8. https://doi.org/10.21037/sci-2020-001

  65. Borysowski J, Górski A (2020) Ethics framework for treatment use of investigational drugs. BMC Med Ethics 21:116. https://doi.org/10.1186/s12910-020-00560-9

    Article  PubMed  PubMed Central  Google Scholar 

  66. Sürder D, Radrizzani M, Turchetto L, Cicero VL, Soncin S, Muzzarelli S, Auricchio A, Moccetti T (2013) Combined delivery of bone marrow-derived mononuclear cells in chronic ischemic heart disease: rationale and study design. Clin Cardiol 36(8):435–441. https://doi.org/10.1002/clc.22148

    Article  PubMed  PubMed Central  Google Scholar 

  67. Heldman AW, DiFede DL, Fishman JE, Zambrano JP, Trachtenberg BH, Karantalis V, Mushtaq M, Williams AR, Suncion VY, McNiece IK, Ghersin E, Soto V, Lopera G, Miki R, Willens H, Hendel R, Mitrani R, Pattany P, Feigenbaum G, Oskouei B, Hare JM (2014) Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial. JAMA 311(1):62–73. https://doi.org/10.1001/jama.2013.282909

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Aderinto N, Abdulbasit MO, Olatunji D (2023) Stem cell-based combinatorial therapies for spinal cord injury: a narrative review of current research and future directions. Ann Med Surg 85(8):3943–3954. https://doi.org/10.1097/MS9.0000000000001034

    Article  Google Scholar 

  69. Choudry F, Hamshere S, Saunders N, Veerapen J, Bavnbek K, Knight C, Pellerin D, Locca D, Westwood M, Rakhit R, Crake T, Kastrup J, Parmar M, Agrawal S, Jones D, Martin J, Mathur A (2016) A randomized double-blind control study of early intra-coronary autologous bone marrow cell infusion in acute myocardial infarction: the REGENERATE-AMI clinical trial†. Eur Heart J 37(3):256–263. https://doi.org/10.1093/eurheartj/ehv493

    Article  PubMed  Google Scholar 

  70. Quyyumi AA, Vasquez A, Kereiakes DJ, Klapholz M, Schaer GL, Abdel-Latif A, Frohwein S, Henry TD, Schatz RA, Dib N, Toma C, Davidson CJ, Barsness GW, Shavelle DM, Cohen M, Poole J, Moss T, Hyde P, Kanakaraj AM, Druker V, Losordo DW (2017) PreSERVE-AMI: a randomized, double-blind, placebo-controlled clinical trial of intracoronary administration of autologous CD34+ cells in patients with left ventricular dysfunction post STEMI. Circ Res 120(2):324–331. https://doi.org/10.1161/CIRCRESAHA.115.308165

    Article  CAS  PubMed  Google Scholar 

  71. Wollert KC, Meyer GP, Müller-Ehmsen J, Tschöpe C, Bonarjee V, Larsen AI, May AE, Empen K, Chorianopoulos E, Tebbe U, Waltenberger J, Mahrholdt H, Ritter B, Pirr J, Fischer D, Korf-Klingebiel M, Arseniev L, Heuft HG, Brinchmann JE, Messinger D, Bauersachs J (2017) Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial. Eur Heart J 38(39):2936–2943. https://doi.org/10.1093/eurheartj/ehx188

    Article  CAS  PubMed  Google Scholar 

  72. Butler J, Epstein SE, Greene SJ, Quyyumi AA, Sikora S, Kim RJ, Anderson AS, Wilcox JE, Tankovich NI, Lipinski MJ, Ko YA, Margulies KB, Cole RT, Skopicki HA, Gheorghiade M (2017) Intravenous allogeneic mesenchymal stem cells for nonischemic cardiomyopathy: safety and efficacy results of a phase II-A randomized trial. Circ Res 120(2):332–340. https://doi.org/10.1161/CIRCRESAHA.116.309717

    Article  CAS  PubMed  Google Scholar 

  73. Nicolau JC, Furtado RHM, Silva SA, Rochitte CE, Rassi A Jr, Moraes JBMC Jr, Quintella E, Costantini CR, Korman APM, Mattos MA, Castello HJ Jr, Caixeta A, Dohmann HFR, de Carvalho ACC, MiHeart AMII (2018) Stem-cell therapy in ST-segment elevation myocardial infarction with reduced ejection fraction: a multicenter, double-blind randomized trial. Clin Cardiol 41(3):392–399. https://doi.org/10.1002/clc.22882

    Article  PubMed  PubMed Central  Google Scholar 

  74. Hare JM, DiFede DL, Rieger AC, Florea V, Landin AM, El-Khorazaty J, Khan A, Mushtaq M, Lowery MH, Byrnes JJ, Hendel RC, Cohen MG, Alfonso CE, Valasaki K, Pujol MV, Golpanian S, Ghersin E, Fishman JE, Pattany P, ... Heldman AW (2017) Randomized comparison of allogeneic versus autologous mesenchymal stem cells for nonischemic dilated cardiomyopathy: POSEIDON-DCM Trial. J Am Coll Cardiol 69(5):526–537. https://doi.org/10.1016/j.jacc.2016.11.009

Download references

Author information

Authors and Affiliations

  1. Department of Medicine and Surgery, University of Ilorin, Ilorin, Nigeria

    Gbolahan Olatunji, Emmanuel Kokori & Emmanuel Ayanleke

  2. Department of Medicine and Surgery, Obafemi Awolowo University, Osun, Nigeria

    Ismaila Yusuf

  3. Department of Medicine and Surgery, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria

    Olakanmi Damilare, Samson Afolabi, Busayo Adetunji, Gbolahan Aboderin & Nicholas Aderinto

  4. Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

    Saad Mohammed

  5. College of Medicine, University of Ibadan, Ibadan, Nigeria

    Olumide Akinmoju

Authors
  1. Gbolahan Olatunji
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emmanuel Kokori
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ismaila Yusuf
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Emmanuel Ayanleke
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Olakanmi Damilare
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Samson Afolabi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Busayo Adetunji
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Saad Mohammed
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Olumide Akinmoju
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Gbolahan Aboderin
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Nicholas Aderinto
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

NA contributed to the study conception and design. Nicholas Aderinto and Gbolahan Olatunji performed material preparation, data collection, and analysis. All authors wrote the first draft of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Nicholas Aderinto.

Ethics declarations

Ethical standards

The manuscript does not contain clinical studies or patient data.

Consent to participate

Not applicable.

Conflict of interest

The authors declare no competing interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Olatunji, G., Kokori, E., Yusuf, I. et al. Stem cell-based therapies for heart failure management: a narrative review of current evidence and future perspectives. Heart Fail Rev 29, 573–598 (2024). https://doi.org/10.1007/s10741-023-10351-0

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10741-023-10351-0

Keywords

Search

Navigation