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Morphological study of cellulosic hydrogel nanofiber for biomedical application

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Abstract

In this work, water-insoluble and biocompatible hydrogel nanoweb was prepared via electrospinning. Sodium carboxymethyl cellulose (CMCNa), the cellulose derivative with water solubility and biocompatibility, was electrospun with help of building polymer, poly(ethylene oxide) (PEO). After removal of PEO, the CMCNa in the nanoweb was ionically crosslinked by FeCl3. The viscosity of the mixed solution was decreased with the increase of PEO content mainly due to the smaller molecular size of PEO comparing to CMCNa. The reduced interaction resulted from small molecular size decreased the viscosity with the increase of PEO content. The PEO also improved the spinnability of the solution by screening repulsive force between the CMCNa molecules. As a result, the increase of PEO content resulted in the decreases of the viscosity and the fiber diameter simultaneously. After extraction of PEO, the diameter was significantly reduced. The surface of the nanowebs became bumpy after crosslinking and fiber diameter increased with the increase of crosslinking time. The chemical structure changes of the nanowebs during the process were analyzed by FT-IR spectra. The cytotoxicity of the nanoweb was also assessed using MTT assay. Furthermore, the drug release behaviors of the nanowebs were evaluated using UV–Vis spectrometer. The nanoweb with increased fiber diameter showed more sustained release behavior because of its low specific surface area.

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Acknowledgments

This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science (NRF-2018R1A2B6003570). This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Ministry of Science and ICT for First-Mover Program for Accelerating Disruptive Technology Development (2018M3C1B9069748).

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Authors and Affiliations

  1. Department of Organic and Nano System Engineering, Konkuk University, Seoul, 05029, Republic of Korea

    Eunjoo Ko

  2. Department of Biological Engineering, Konkuk University, Seoul, 05029, Republic of Korea

    Ki Soo Park & Seokjoon Kim

  3. Division of Chemical Engineering, Konkuk University, Seoul, 05029, Republic of Korea

    Taeho Kim & Hyungsup Kim

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  1. Eunjoo Ko
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  2. Ki Soo Park
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Correspondence to Hyungsup Kim.

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Ko, E., Park, K.S., Kim, S. et al. Morphological study of cellulosic hydrogel nanofiber for biomedical application. Cellulose 26, 9107–9118 (2019). https://doi.org/10.1007/s10570-019-02725-1

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