Abstract
The objective of this study was to investigate the relationship of echocardiographic epicardial fat thickness (EFT) and neutrophil to lymphocyte ratio (NLR) with different types of non-valvular atrial fibrillation (AF) in a clinical setting. A total of 197 consecutive patients were enrolled in the study. Seventy-one patients had paroxysmal non-valvular AF, 63 patients had persistent/permanent non-valvular AF, and 63 patients had sinus rhythm (control group). EFT was measured with echocardiography, while NLR was measured by dividing neutrophil count by lymphocyte count. EFT was significantly higher in patients with paroxysmal non-valvular AF compared with those in the sinus rhythm group (6.6 ± 0.7 vs. 5.0 ± 0.9 mm, p < 0.001). Persistent/permanent non-valvular AF patients had a significantly larger EFT compared with those with paroxysmal AF (8.3 ± 1.1 vs. 6.6 ± 0.7 mm, p < 0.001). EFT had a significant relationship with paroxysmal non-valvular AF (odds ratio 4.672, 95 % CI 2.329–9.371, p < 0.001) and persistent/permanent non-valvular AF (OR 24.276, 95 % CI 9.285–63.474, p < 0.001). NLR was significantly higher in those with paroxysmal non-valvular AF compared with those in the sinus rhythm group (2.5 ± 0.6 vs. 1.8 ± 0.4, p < 0.001). Persistent/permanent non-valvular AF patients had a significantly larger NLR when compared with paroxysmal non-valvular AF patients (3.4 ± 0.6, vs. 2.5 ± 0.6, p < 0.001). NLR (>2.1) had a significant relationship with non-valvular AF (OR 11.313, 95 % CI 3.025–42.306, b 2.426, p < 0.001). EFT and NLR are highly associated with types of non-valvular AF independent of traditional risk factors. EFT measured by echocardiography and NLR appears to be related to the duration and severity of AF.
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Ertaş F, Kaya H, Kaya Z, Bulur S, Köse N, Gül M, Kahya Eren N, Cağlıyan CE, Köroğlu B, Vatan B, Acar G, Yüksel M, Bilik MZ, Gedik S, Simşek Z, Akıl MA, Yılmaz R, Oylumlu M, Arıbaş A, Yıldız A, Aydın M, Yeter E, Kanadaşı M, Ergene O, Ozhan H, Ulgen MS (2013) Epidemiology of atrial fibrillation in Turkey: preliminary results of the multicenter AFTER study. Turk Kardiyol Dern Ars 41(2):99–104. doi:10.5543/tkda.2013.18488
Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S et al (2010) European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery, guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 31:2369–2429
Shen XH, Chen Q, Shi Y, Li HW (2010) Association of neutrophil/lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention. Chin Med J 123:3438–3443
Kaya H, Ertas F, Islamoglu Y, Kaya Z, Atilgan ZA, Cil H, Caliskan A, Aydin M, Oylumlu M, Soydinç MS (2013) Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost. doi:10.1177/1076029612452116
Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H et al (2003) Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108:2460–2466
Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS et al (2008) Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: The Framingham Heart Study. Circulation 117:605–613
Ertas F, Kaya H, Acet H, Cil H, Akyüz A, Islamoğlu Y, Tekbaş E, Aritürk Z, Aydin M, Soydinç S (2012) Increased echocardiographic epicardial fat thickness is related to impaired diurnal blood pressure profiles. Blood Press 21(3):202–208. doi:10.3109/08037051.2011.649538
Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG et al (2007) Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: The Framingham Heart Study. Circulation 116:1234–1241
Psychari SN, Apostolou TS, Sinos L, Hamodraka E, Liakos G, Kremastinos DT (2005) Relation of elevated C-reactive protein and interleukin-6 levels to left atrial size and duration of episodes in patients with atrial fibrillation. Am J Cardiol 95:764–767
Sata N, Hamada N, Horinouchi T, Amitani S, Yamashita T, Moriyama Y et al (2004) C-reactive protein and atrial fibrillation. Is inflammation a consequence or a cause of atrial fibrillation? Jpn Heart J 45:441–445
Watanabe E, Arakawa T, Uchiyama T, Kodama I, Hishida H (2006) Highsensitivity C-reactive protein is predictive of successful cardioversion for atrial fibrillation and maintenance of sinus rhythm after conversion. Int J Cardiol 108:346–353
Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, Di Mario U et al (2003) Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res 11:304–310
Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H et al (1989) Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 2:358–367
Korantzopoulos P, Kolettis TM, Galaris D, Goudevenos JA (2007) The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation. Int J Cardiol 115(2):135–143
Aviles RJ, Martin DO, Apperson-Hansen C, Houghtaling PL, Rautaharju P, Kronmal RA, Tracy RP, Van Wagoner DR, Psaty BM, Lauer MS, Chung MK (2003) Inflammation as a risk factor for atrial fibrillation. Circulation 108:3006–3010
Malouf JF, Kanagala R, Al Atawi FO, Rosales AG, Davison DE, Murali NS, Tsang TS, Chandrasekaran K, Ammash NM, Friedman PA, Somers VK (2005) High sensitivity C-reactive protein: a novel predictor for recurrence of atrial fibrillation after successful cardioversion. J Am Coll Cardiol 46:1284–1287
Gualillo O, Gonzalez-Juanatey JR, Lago F (2007) The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives. Trends Cardiovasc Med 17(8):275–283
Iacobellis G, Corradi D, Sharma AM (2005) Epicardial adipose tissue: anatomical, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med 2:536–543
Venteclef N, Guglielmi V, Balse E, Gaborit B, Cotillard A, Atassi F, Amour J, Leprince P, Dutour A, Clément K, Hatem SN (2013) Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines. Eur Heart J [Epub ahead of print]
Abed HS, Wong CX, Brooks AG (2010) Periatrial fat volume is predictive of atrial fibrillation severity. Heart Rhythm 7(Suppl):S327
Batal O, Schoenhagen P, Shao M, Ayyad AE, Van Wagoner DR, Halliburton SS, Tchou PJ, Chung MK (2010) Left atrial epicardial adiposity and atrial fibrillation. Circ Arrhythm Electrophysiol 3(3):230–236. doi:10.1161/CIRCEP.110.957241
Kourliouros A, Karastergiou K, Nowell J, Gukop P, Tavakkoli Hosseini M, Valencia O, Mohamed Ali V, Jahangiri M (2011) Protective effect of epicardial adiponectin on atrial fibrillation following cardiac surgery. Eur J Cardiothorac Surg 39(2):228–232. doi:10.1016/j.ejcts.2010.05.006
Nakanishi K, Fukuda S, Tanaka A, Otsuka K, Sakamoto M, Taguchi H, Yoshikawa J, Shimada K, Yoshiyama M (2012) Peri-atrial epicardial adipose tissue is associated with new-onset nonvalvular atrial fibrillation. Circ J 76(12):2748–2754 Epub 2012 Aug 22
Iacobellis G, Willens HJ (2009) Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr 22(12):1311–1319
Fox CS, Gona P, Hoffmann U, Porter SA, Salton CJ, Massaro JM, Levy D, Larson MG, D’Agostino RB Sr, O’Donnell CJ, Manning WJ (2009) Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study. Circulation 119(12):1586–1591
Al Chekakie MO, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J, Santucci P, Wilber DJ, Akar JG (2010) Pericardial fat is independently associated with human atrial fibrillation. J Am Coll Cardiol 56(10):784–788
Horne BD, Anderson JL, John JM, Weaver A, Bair TL, Jensen KR et al (2005) Intermountain Heart Collaborative Study Group. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol 45:1638–1643
Zahorec R (2001) Ratio of neutrophil to lymphocyte counts rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 102(1):5–14
Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS (2008) Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 102(6):653–657
de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC (2010) Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 14(5):R192. doi:10.1186/cc9309 Epub 2010 Oct 29
Gibson PH, Cuthbertson BH, Croal BL, Rae D, El-Shafei H, Gibson G, Jeffrey RR, Buchan KG, Hillis GS (2010) Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 105(2):186–191. doi:10.1016/j.amjcard.2009.09.007 Epub 2009 Dec 3
Im SI, Shin SY, Na JO, Kim YH, Choi CU, Kim SH, Kim JW, Kim EJ, Han SW, Rha SW, Park CG, Seo HS, Oh DJ, Hwang C, Lim HE (2013) Usefulness of neutrophil/lymphocyte ratio in predicting early recurrence after radiofrequency catheter ablation in patients with atrial fibrillation. Int J Cardiol. doi:10.1016/j.ijcard.2013.05.042
Canpolat U, Aytemir K, Yorgun H, Sahiner L, Kaya EB, Kabakçı G, Tokgözoğlu L, Oto A (2013) Role of preablation neutrophil/lymphocyte ratio on outcomes of cryoballoon-based atrial fibrillation ablation. Am J Cardiol. doi:10.1016/j.amjcard.2013.04.015
Ertaş G, Sönmez O, Turfan M, Kul S, Erdoğan E, Tasal A, Bacaksiz A, Vatankulu MA, Altıntaş O, Uyarel H, Göktekin O (2013) Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation. J Neurol Sci 324(1–2):49–52. doi:10.1016/j.jns.2012.09.032
Iacobellis G, Leonetti F, Singh N, Sharma MA (2007) Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects. Int J Cardiol 115(2):272–273
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Acet, H., Ertaş, F., Akıl, M.A. et al. New inflammatory predictors for non-valvular atrial fibrillation: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio. Int J Cardiovasc Imaging 30, 81–89 (2014). https://doi.org/10.1007/s10554-013-0317-4
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DOI: https://doi.org/10.1007/s10554-013-0317-4