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Flattened fiber-optic ATR sensor enhanced by silver nanoparticles for glucose measurement

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Abstract

This paper proposes a novel fiber attenuated total reflection (ATR) sensor with silver nanoparticles (AgNPs) on the flattened structure based on mid-infrared spectroscopy for detecting low concentration of glucose with high precision. The flattened structure was designed to add the effective optical path length to improve the sensitivity. AgNPs were then deposited on the surface of the flattened area of the fiber via chemical silver mirror reaction for further improving the sensitivity by enhancing the infrared absorption. Combining the AgNPs modified flattened fiber ATR sensor with a CO2 laser showed a strong mid-infrared glucose absorption, with an enhancement factor of 4.30. The glucose concentration could be obtained by a five-variable partial least-squares model with a root-mean-square error of 4.42 mg/dL, which satisfies clinical requirements. Moreover, the fiber-based technique provides a pretty good method to fabricate miniaturized ATR sensors that are suitable to be integrated into a microfluidic chip for continuous glucose monitoring with high sensitivity.

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Funding

This work was supported by the National Natural Science Foundation of China (No.81571766), the National Key Research and Development Program of China (No.2017YFA0205103), and the 111 Project of China (No.B07014).

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Authors and Affiliations

  1. State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin, China

    Wenwen Li, Changyue Sun, Zhihua Pu, Penghao Zhang, Kexin Xu & Dachao Li

  2. Temperature Laboratory, Tianjin Institute of Metrological Supervision Testing, Tianjin, China

    Songlin Yu

  3. NHC Key Laboratory of Hormones and Development (Tianjin Medical University) , Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin, China

    Zhenqiang Song

Authors
  1. Wenwen Li
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  2. Changyue Sun
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  3. Songlin Yu
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  4. Zhihua Pu
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  5. Penghao Zhang
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  6. Kexin Xu
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  7. Zhenqiang Song
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  8. Dachao Li
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Correspondence to Zhenqiang Song or Dachao Li.

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Li, W., Sun, C., Yu, S. et al. Flattened fiber-optic ATR sensor enhanced by silver nanoparticles for glucose measurement. Biomed Microdevices 20, 104 (2018). https://doi.org/10.1007/s10544-018-0346-9

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  • DOI: https://doi.org/10.1007/s10544-018-0346-9

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