Abstract
Bio-actuated micro-pumps do not need any external power source and pose no risk of electrical or heat shock for the biological materials in lab-on-chip systems. Several different designs of bio-actuated micro-pumps based on the use of the contractile force of cultured cardiomyocites have been proposed earlier. Here we present a novel type of a bio-actuated micro-pump representing a microfluidic channel with a contractile wall. The flow inside the channel is generated by the peristaltic movement of its wall caused by the propagation of an excitation-contraction wave along the channels surface. The directional flow generated by the pump was demonstrated by tracking of polystyrene microspheres, moving in the direction of the propagation of the excitation-contraction wave with an average velocity of 6–8 μm/min. The suggested design of a micro-pump allows the control of pumping direction, which might be useful for targeted delivery of fluids and substances in lab-on-chip systems. Prospects of future development and implementation of this kind of bio-actuated peristaltic pumps are discussed.
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This research work was partially supported by the Russian Foundation for Basic Research grant 16-34-60225.
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Shutko, A.V., Gorbunov, V.S., Guria, K.G. et al. Biocontractile microfluidic channels for peristaltic pumping. Biomed Microdevices 19, 72 (2017). https://doi.org/10.1007/s10544-017-0216-x
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DOI: https://doi.org/10.1007/s10544-017-0216-x