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Blood Cytokines of the Ovarian Vein Basin in Different Stages of Pelvic Varicose Veins

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We analyzed the blood concentration of pro- and anti-inflammatory cytokines in the ovarian vein basin area in women of the reproductive age with primary pelvic varices. Increase in the disease severity was accompanied by a significant increase in proinflammatory cytokines (TNFα, IL-1β, IL-2, IL-6, and IL-8) and the proinflammatory index (IL-6/IL-10), whereas anti-inflammatory cytokine production changed ambiguously (increase of IL-4 at stage I, decrease of IL-10 at stage II, significant decrease of IL-4 and IL-10 at stage III). Control of these changes in female patients should probably be an important component of treatment measures and prevention of morphofunctional disorders occurring at disease progression, in particular at stage III of the disease.

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Authors and Affiliations

  1. Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia

    M. A. Darenskaya, D. A. Stupin, S. I. Kolesnikov, N. V. Semenova & L. I. Kolesnikova

  2. Irkutsk State Medical University, Ministry of health of the Russian Federation, Irkutsk, Russia

    A. A. Semendyaev, D. A. Stupin & K. V. Pesterev

  3. Irkutsk State University, Irkutsk, Russia

    L. I. Kolesnikova

Authors
  1. M. A. Darenskaya
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  2. A. A. Semendyaev
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  3. D. A. Stupin
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  4. S. I. Kolesnikov
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  5. N. V. Semenova
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  6. K. V. Pesterev
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  7. L. I. Kolesnikova
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Corresponding author

Correspondence to M. A. Darenskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 3, pp. 286-290, March, 2023

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Darenskaya, M.A., Semendyaev, A.A., Stupin, D.A. et al. Blood Cytokines of the Ovarian Vein Basin in Different Stages of Pelvic Varicose Veins. Bull Exp Biol Med 175, 311–314 (2023). https://doi.org/10.1007/s10517-023-05858-3

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  • DOI: https://doi.org/10.1007/s10517-023-05858-3

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