In patients with chronic obstructive pulmonary disease, the levels of cytokines IL-1β, IL-4, IL-8, TNFα, and IFNγ depended on the degree of bronchial obstruction and severity and period of the disease. The maximum levels of IL-4, IL-8, and TNFα were observed in severe chronic obstructive pulmonary disease during exacerbation. The highest concentration of IL-1β and IFNγ were recorded during activation of inflammation in patients with moderate bronchial obstruction. The revealed correlations between the tested cytokines and spirometry parameters make it possible to consider the levels of these proteins as quantitative markers of systemic inflammation progression.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 6, pp. 732-735, June, 2022
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Kubysheva, N.I., Postnikova, L.B., Soodaeva, S.K. et al. Comparative Study of the Levels of IL-1β, IL-4, IL-8, TNFα, and IFNγ in Stable Course and Exacerbation of Chronic Obstructive Pulmonary Disease of Varying Severity. Bull Exp Biol Med 173, 745–748 (2022). https://doi.org/10.1007/s10517-022-05622-z
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DOI: https://doi.org/10.1007/s10517-022-05622-z