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Wealth index is significantly associated with the early phase of fracture healing among fractured patients at the University of Gondar Specialized Hospital, Northwest Ethiopia

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Abstract

Introduction

Bone fracture is a cause of 5 million annual injuries globally. It contributes to profound physical impairment, a reduction in quality of life, long hospitalization time, and reduced institutional care. The socioeconomical impact of bone fracture will be high in the next 50 years in developing countries, including Ethiopia. This study aimed to assess the factors associated with the early phase of fracture healing among fractured adult patients at the University of Gondar Specialized hospital, Northwest Ethiopia.

Methods

A secondary data analysis was done from the previous institution-based prospective follow-up study from March to June 2015. An interviewer-administered pretested and structured questionnaire was used to collect the data. Early ossification of fractured bone was defined when the bone was ossified/calcified within 1 month of the fracture using X-ray findings. Data were entered into EpiInfo version 3.5.3 software and exported to SPSS version 20 for Windows for further analysis. Binary logistic regression analysis was employed to find factors associated with early ossification of a fractured bone. In the multivariable model, variables that had a p–value of < 0.05 were considered statistically significant. Also, a 95% CI for odds ratios was calculated to see the degree of association.

Results

In total, 118 participants with a bone fracture participated in this study. Of all, 36.4% of them had ossified bone during the early phase of bone healing. Dietary diversity score (DDS) [AOR = 18.6, 95% CI (4.10–84.34)], the type of fractured bone [AOR: = 0.13, 95% CI (0.03–0.50)], and household wealth index [AOR = 8.6, 95% CI (1.51–49.05)] were independently associated with the early phase of fractured bone healing/ossification.

Conclusion

Bone ossification during the first month of fracture was low. Dietary diversity score, type of fractured bone, and household wealth index were the factors associated with the early phase of bone ossification. So, improving dietary practice after the incident is essential. Also, health care providers will have to consider the fractured bone type and household assets during the clinical intervention for fractured bone.

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References

  • Allen MR, Hock JM, Burr DB (2004) Periosteum: biology, regulation, and response to osteoporosis therapies. Bone 35:1003–1012

    Article  CAS  PubMed  Google Scholar 

  • Askew A, Chakkalakal D, Fang X, McGuire M (2011) Delayed fracture healing in alcohol abusers — a preliminary retrospective study. Open Bone J 3:1–5

    Article  Google Scholar 

  • Bhattacharyya T, Levin R, Vrahas MS, Solomon DH (2005) Nonsteroidal anti-inflammatory drugs and nonunion of humeral shaft fractures. Arthritis Rheum 53(3):364–367

    Article  CAS  PubMed  Google Scholar 

  • Bishop JA, Palanca AA, Bellino MJ, Lowenberg DW (2012) Assessment of compromised fracture healing. J Am Acad Orthop Surg 20:273–282

    Article  PubMed  Google Scholar 

  • Boursinos LA, Karachalios T, Poultsides L, Malizos KN (2009) Do steroids, conventional non-steroidal anti-inflammatory drugs, and selective Cox-2 inhibitors adversely affect fracture healing? J Musculoskelet Neuronal Interact 9(1):44–52

    CAS  PubMed  Google Scholar 

  • Brinker MR, O’Connor DP, Monla YT, Earthman TP (2007) Metabolic and endocrine abnormalities in patients with non-unions. J Orthop Trauma 21:557–570

    Article  PubMed  Google Scholar 

  • Court-Brown CM, McQueen MM (2008) Non-unions of the proximal humerus: their prevalence and functional outcome. J Trauma 64(6):1517–1521

    PubMed  Google Scholar 

  • Day SM, DeHeer DH (2001) Reversal of the detrimental effects of chronic protein malnutrition on long bone fracture healing. J Orthop Trauma 15:47–53

    Article  CAS  PubMed  Google Scholar 

  • Dhanwal DK, Sahoo S, Gautam VK, Saha R (2013) Hip fracture patients in India have vitamin D deficiency and secondary hyperparathyroidism. Osteoporos Int 24(2):553–557

    Article  CAS  PubMed  Google Scholar 

  • Ettehad H, Mirbolook A, Mohammadi F, Mousavi M, Ebrahimi H, Shirangi A (2014) Changes in the serum level of vitamin D during healing of tibial and femoral shaft fractures. Trauma Mon 19(1):25

    Article  Google Scholar 

  • Fentaw Y, Woldie H, Mekonnen S, Tesgay AT (2017) Change in serum level of vitamin D and associated factors at the early phase of bone healing among fractured adult patients at University of Gondar teaching hospital, Northwest Ethiopia: a prospective follow up study. Nutr J 16:54. https://doi.org/10.1186/s12937-017-0277-y

    Article  PubMed  PubMed Central  Google Scholar 

  • Foote J, Murphy S, Wilkens L, Basiotis P, Carlson A (2004) Dietary variety increases the probability of nutrient adequacy among adults. J Nutr 134:1779–1785

    Article  CAS  PubMed  Google Scholar 

  • Gerstenfeld LC, Cullinane DM, Barnes GL, Graves DT, Einhorn TA (2003) Fracture healing as a postnatal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88(5):873–884

    Article  CAS  PubMed  Google Scholar 

  • Gruber R, Koch H, Doll BA, Tegtmeier F, Einhorn TA, Hollinger JO (2006) Fracture healing in the elderly patient. Exp Gerontol 41(11):1080–1093

    Article  PubMed  Google Scholar 

  • Gustilo RB, Gruninger RP, Davis T (1987) Classification of type III (severe) open fractures relative to treatment and results. Orthopaedics 10:1781–1788

    CAS  Google Scholar 

  • Hatley A, Hedlund J, Diarra MM, Oshaug A (2000) Food variety, socioeconomic status and nutritional status in urban and rural areas in Koutiala (Mali). Public Health Nutr 3:57–65

    Article  Google Scholar 

  • Hernandez RK, Do TP, Critchlow CW, Dent RE, Jick SS (2012) Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database. Acta Orthop 83:653–660

    Article  PubMed  PubMed Central  Google Scholar 

  • Hernigou J, Schuind F (2013) Smoking as a predictor of a negative outcome in diaphyseal fracture healing. Int Orthop 37(5):883–887

    Article  PubMed  PubMed Central  Google Scholar 

  • Howe LD, Hargreaves JR, Huttly SR (2008) Issues in the construction of wealth indices for the measurement of socioeconomic position in low-income countries. Emerg Themes Epidemiol 5:3

    Article  PubMed  PubMed Central  Google Scholar 

  • Jones ET (2003) Skeletal growth and development as related to trauma. J Forensic Sci 17:189–198

    Google Scholar 

  • Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637–650

    Article  CAS  PubMed  Google Scholar 

  • Kennedy G, Ballard T, Dop MC (2011) Guidelines for measuring household and individual dietary diversity. FAO, Rome, p 56

  • Kozin SH (2001) Incidence, mechanism, and natural history of scaphoid fractures. Hand Clin 17:515–524

    Article  CAS  PubMed  Google Scholar 

  • Lindaman LM (2001) Bone healing in children. Clin Podiatr Med Surg 18(1):97–108

    CAS  PubMed  Google Scholar 

  • Lu C, Miclau T, Hu D, Hansen E, Tsui K, Puttlitz C, Marcucio RS (2005) Cellular basis for age-related changes in fracture repair. J Orthop Res 23(6):1300–1307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • MacKenzie EJ, Bosse MJ, Pollak AN et al (2005) Long-term persistence of disability following severe lower-limb trauma. Results of a seven-year follow-up. J Bone Joint Surg Am 87:1801–1809

    PubMed  Google Scholar 

  • Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M (2013) Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 229:176–185

    Article  CAS  PubMed  Google Scholar 

  • Marsell R, Einhorn TA (2011) The biology of fracture healing. Injury 42(6):551–555

    Article  PubMed  PubMed Central  Google Scholar 

  • Marsh DR, Li G (1999) The biology of fracture healing: optimizing outcome. Br Med Bull 55:856–889

    Article  CAS  PubMed  Google Scholar 

  • McKibbin B (1978) The biology of fracture healing in long bones. J Bone Joint Surg 60-B(2):150–162

    Article  CAS  Google Scholar 

  • Montgomery M, Gragnolati M, Burke K, Paredes E (2000) Measuring living standards with proxy variables. Demography 37(2):155–174

    Article  CAS  PubMed  Google Scholar 

  • Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958–969

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murray CJL, Lopez AD (1996) Global health statistics: a compendium of incidence, prevalence and mortality estimates for over 200 conditions. Harvard University Press, Cambridge, MA, USA

    Google Scholar 

  • Neyens J, Halfens R, Spreeuwenberg M, Meijers J, Luiking Y, Verlaan G, Schols J (2013) Malnutrition is associated with an increased risk of falls and impaired activity in elderly patients in Dutch residential long-term care (LTC): a cross-sectional study. Arch Gerontol Geriatr 56:265–269

    Article  PubMed  Google Scholar 

  • Nich C, Takakubo Y, Pajarinen J, Ainola M, Salem A, Sillat T, Rao AJ et al (2013) Macrophages—key cells in the response to wear debris from joint replacements. J Biomed Mater Res A 101:3033–3045

    Article  PubMed  PubMed Central  Google Scholar 

  • Nordberg E (1994) Injuries in Africa. East Afr Med J 7(6):339–345

    Google Scholar 

  • Nuti R, Martini G, Valenti R, Gambera D, Gennari L, Salvadori S et al (2004) Vitamin D status and bone turnover in women with acute hip fracture. Clin Orthop Relat Res 422:208–213

    Article  Google Scholar 

  • Omran AR (1977) Epidemiological transition in the United States, the health sector in population change. Popul Bull 32:1–42

    CAS  PubMed  Google Scholar 

  • Parchi P, Andreani L, Piolanti N, Niccolai F, Cervi V, Lisanti M (2014) Effect of vitamin D in fracture healing in a child. Arch Osteoporos 9:170

    Article  PubMed  Google Scholar 

  • Parker MJ, Raghavan R, Gurusamy K (2007) Incidence of fracture-healing complications after femoral neck fractures. Clin Orthop Relat Res 458:175–179

    Article  PubMed  Google Scholar 

  • Patel RA, Wilson RF, Patel PA, Palmer RM (2013) The effect of smoking on bone healing: a systematic review. Bone Joint Res 2(6):102–111

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Phieffer LS, Goulet JA (2006) Delayed unions of the tibia. Instr Course Lect 55:389–401

    PubMed  Google Scholar 

  • Pscherer S, Sandmann GH, Ehnert S, Nussler AK, Stockle U, Freude T (2015) Delayed fracture healing in diabetics with distal radius fractures. Acta Chir Orthop Traumatol Cechoslov 82(4):268–273

    CAS  Google Scholar 

  • Ramason R, Selvaganapathi N, Binte-Ismail HN, Chin-Wong CW, Rajamoney NG, Chong SM (2014) Prevalence of vitamin D deficiency in patients with hip fracture seen in an orthogeriatric service in sunny Singapore. Geriatr Orthop Surg Rehabil 5(2):82–86

    Article  PubMed  PubMed Central  Google Scholar 

  • Roberts SJ, van Gastel N, Carmeliet G, Luyten FP (2015) Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath. Bone 70C:10–18

    Article  Google Scholar 

  • Robinson CM, Court-Brown CM, McQueen MM, Wakefield AE (2004) Estimating the risk of nonunion following nonoperative treatment of a clavicular fracture. J Bone Jt Surg Am 86-A:1359–1365

    Article  Google Scholar 

  • Rodrigo MD (2007) Peak bone mass measured by phalangeal BMD and its association with nutritional status, socio-economic status and physical activity. Osteoporos Int 18

  • Rosenberg GA, Sferra JJ (2000) Treatment strategies for acute fractures and nonunions of the proximal fifth metatarsal. J Am Acad Orthop Surg 8:332–338

    Article  CAS  PubMed  Google Scholar 

  • Ruel M, Graham J, Murphy S, Allen L (2004) Validating simple indicators of dietary and animal source food intake that accurately reflect nutrient adequacy in developing countries. Report submitted to GL-CRSP. Global Livestock Collaborative Research Support Program, University of California, Davis, CA

  • Sahn DE (2003) Exploring alternative measures of welfare in the absence of expenditure data. Rev Income Wealth 49(4):463–489

    Article  Google Scholar 

  • Savy M, Martin-Prevel Y, Sawadogo P, Kameli Y, Delpeuch F (2005) Use of variety/diversity scores for diet quality measurement: relation with nutritional status of women in a rural area in Burkina Faso. Eur J Clin Nutr 59:703–716

    Article  CAS  PubMed  Google Scholar 

  • Canadian Orthopaedic Trauma Society (2003) Nonunion following intramedullary nailing of the femur with and without reaming. Results of a multicenter randomized clinical trial. J Bone Joint Surg Am 11:2093–2096

    Article  Google Scholar 

  • St-Arnaud R, Naja RP (2011) Vitamin D metabolism, cartilage and bone fracture repair. Mol Cell Endocrinol 347(1–2):48–54

    Article  CAS  PubMed  Google Scholar 

  • Stover M, Callaci JJ (2012) Mesenchymal stem cells facilitate fracture repair in an alcohol-induced impaired healing model. J Orthop Trauma 26(12):712–718

    Article  PubMed  PubMed Central  Google Scholar 

  • [No authors listed] (1991) Dietary reference values for food energy and nutrients for the United Kingdom. Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy. Rep Health Soc Subj (Lond) 41:1–210

  • O'Connell Smeltzer SC, Bare BG, Hinkle JL (2010) Brunner & Suddarth's textbook of medical–surgical nursing. Lippincott Williams & Wilkins, Philadelphia, PA, 2227 pp

  • WHO (2002) The injury record book: A graphical overview of the global burden of injuries. WHO, Geneva

  • WHO (2013) World Health Organization body mass index (BMI) classification. WHO, Geneva

  • Wijnands KA, Brink PR, Weijers PH, Dejong CH, Poeze M (2012) Impaired fracture healing associated with amino acid disturbances. Am J Clin Nutr 95:1270–1277

    Article  CAS  PubMed  Google Scholar 

  • Woldemichael K, Berhanu N (2011) Magnitude and pattern of injury in Jimma University Specialized Hospital, Southwest Ethiopia. Ethiop J Health Sci 21(3): 155–165

  • Yokoyama K, Itoman M, Uchino M, Fukushima K, Nitta H, Kojima Y (2008) Immediate versus delayed intramedullary nailing for open fractures of the tibial shaft: a multivariate analysis of factors affecting deep infection and fracture healing. Indian J Orthop 42(4):410–419

    Article  PubMed  PubMed Central  Google Scholar 

  • Zura R, Braid-Forbes MJ, Jerry K, Mehta S, Einhorn TA, Watson JT, Della-Rocca GJ, Forbes K, Steen RG (2017) Bone fracture nonunion rate decreases with increasing age: a prospective inception cohort study. Bone 95:26–32

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors would like to express our sincere gratitude to those study participants for their willingness to participate in this study.

Funding

We did not accept any financial support for this project.

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Contributions

YFS and MTE designed the study, carried out statistical analysis, and writing this manuscript. MK and ATT participated in the proposal writing, reviewing, and approval. Finally, all the authors read, commented on, and approved this manuscript before sending it for publication.

Corresponding authors

Correspondence to Yalelet Fentaw Shiferaw or Melaku Tadege Engidaw.

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We, the authors, declare that there is no computing interest.

Ethics approval

An ethical clearance letter was obtained from the institutional review boards of the University of Gondar and the Institute of Public Health (IPH). We obtained a permission letter from the hospital administrative body. Informed written consent was obtained from each study participant after explaining the purpose of the study. The participant's ability to withdraw from the study at any time was disclosed unequivocally. Moreover, the confidentiality of the information was assured by removing personal identifiers during the primary data collection. Counselling related to dietary intake was given to all study participants at the end of the data collection.

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Shiferaw, Y.F., Engidaw, M.T., Kedir, M. et al. Wealth index is significantly associated with the early phase of fracture healing among fractured patients at the University of Gondar Specialized Hospital, Northwest Ethiopia. J Public Health (Berl.) 31, 583–590 (2023). https://doi.org/10.1007/s10389-021-01559-1

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