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Evaluation of the lamina cribrosa in different stages of diabetic retinopathy

  • Clinical Investigation
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Abstract

Purpose

To evaluate the relationship of the peripapillary retina nerve fiber layer (RNFL) and lamina cribrosa (LC) with diabetic retinopathy (DR) in type 2 diabetes mellitus (DM) cases.

Study design

Prospective comparative study.

Methods

This study included 50 non-DR (Group 1), 55 non-proliferative diabetic retinopathy (NPDR) (Group 2), 28 DM cases with proliferative diabetic retinopathy (PDR) (Group 3) and 45 healthy volunteers (Group 4). All participants were evaluated with visual acuity, intraocular pressure (IOP) with Goldman applanation tonometry, anterior segment biomicroscopy, 24 − 2 visual field testing, and dilated fundus examination. Retinal nerve fiber layer (RNFL) thickness, lamina cribrosa thickness (LCT) and anterior lamina cribrosa depth (ALCD) were examined by spectral-domain optical coherence tomography (OCT).

Results

There was no difference between the groups in terms of age and gender. Visual acuity (p < 0.001) was significantly different between the groups, while IOP (p = 0.068) was similar. Mean (p = 0.010), superior-temporal (p = 0.024), and superior-nasal (p = 0.011) RNFL thickness decreased significantly in correlation with the stage of DR. LCT decreased significantly as the stage of DR progressed in both vertical and horizontal radial OCT scans (p < 0.001). ALCD was not different between groups (p = 0.954 for horizontal scan, p = 0.867 for vertical scan).

Conclusion

Peripapillary RNFL and LCT significantly decreases as the DR stage progresses. The biomechanical effects of the LC may also be responsible for diabetes-induced neurodegeneration.

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Acknowledgements

Funding/ support: The authors did not receive any financial support from any public or private source.

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Authors and Affiliations

  1. Department of Ophthalmology, Kayseri City Education and Research Hospital, Kayseri, Turkey

    Semra Koca, Ender Sırakaya & Deniz Kılıc

  2. Department of Ophthalmology, Başakşehir Çam and Sakura City Hospital, İstanbul, Turkey

    Esra Vural

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  1. Semra Koca
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  2. Esra Vural
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Correspondence to Semra Koca.

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S. Koca, None; E. Vural, None; E. Sırakaya, None; D. Kılıc, None.

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Corresponding Author: Semra Koca

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Koca, S., Vural, E., Sırakaya, E. et al. Evaluation of the lamina cribrosa in different stages of diabetic retinopathy. Jpn J Ophthalmol 67, 280–286 (2023). https://doi.org/10.1007/s10384-023-00987-8

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  • DOI: https://doi.org/10.1007/s10384-023-00987-8

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