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Quantification of vascular changes in macular telangiectasia type 2 with AngioTool software

  • Retinal Disorders
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Abstract

Purpose

To compare AngioTool (AT) vascular parameters (VP) between MacTel2 eyes and normal eyes. Secondary outcome measures were to correlate VP with BCVA and to analyze VP between various grades of Simple MacTel Classification.

Methods

This is a retrospective study. SD OCTA images of the superficial vascular complex (SVC) and deep capillary complex (DVC) were exported into Image J and AT. The explant area (EA), vessel area (VA), vessel percentage area (VPA), total number of junctions (TNJ), junction density (JD), total vessel length (TVL), average vessel length (AVL), total number of endpoints (TNE) and mean E lacunarity (MEL) were studied.

Results

Group 1 had 120 MacTel2 eyes. Group 2 had 60 age-matched normal eyes. All VP were significantly different between the two groups except EA and TNE in both complexes. None of the VP had a correlation with BCVA. Interquadrant analysis (IQA) in SVC and DVC showed statistical significance in VPA, AVL and JD and in AVL, TNE, JD, VPA respectively. Post hoc analysis in SVC and DVC showed statistical significance in TNJ, JD, TVL and AVL between grade 1 and grade 3, and in VA, VPA, TNJ, JD, TVL and MEL between grade 0 and grade 3 respectively.

Conclusion

VP were affected in MacTel2 eyes. VP did not correlate with BCVA. Occurrence of pigmentation is an important event in the progression of disease. AT may provide quantitative markers to measure disease progression.

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No funding was received for this research.

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Authors and Affiliations

  1. Department of Vitreo-Retina Services, Aravind Eye Hospital, Chennai, Tamil Nadu, India

    Indu Govindaraj, Maanasi Mahalingam, Uma Maheswari, H. S. Yeshwanth Kumar, B. S. Suganya, Vishnu Subramanian & Anand Rajendran

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  1. Indu Govindaraj
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  2. Maanasi Mahalingam
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  3. Uma Maheswari
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  4. H. S. Yeshwanth Kumar
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  5. B. S. Suganya
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  6. Vishnu Subramanian
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  7. Anand Rajendran
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Corresponding author

Correspondence to Anand Rajendran.

Ethics declarations

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Ethics Committee of Aravind eye Hospital, Chennai, Tamilnadu, India (Project code : AEH/CHN/EC/DODNB/03/2022) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The study or the data have not been published or presented elsewhere.

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Supplementary Information

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417_2024_6487_MOESM1_ESM.jpg

Supplementary file1 Supplementary Figure. SD OCTA image analysis of the deep vascular complex. a. Deep vascular complex (DVC) slab of eye with MacTel2, b. A specific ROI size of 1085*997□m was set for superior, inferior, nasal, and temporal with the edge of the ROI starting at the edge of the avascular zone. c. Cropped image with 4 quadrants d,e. Output image of the quadrants in Angiotool (AT) f. The results of the vascular parameters derived from the AT software. (JPG 297 KB)

417_2024_6487_MOESM2_ESM.docx

Supplementary file2 Supplementary table : Inter-quadrant analysis of vascular parameters in SVC and DVC in age matched healthy eyes. (DOCX 20 KB)

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Govindaraj, I., Mahalingam, M., Maheswari, U. et al. Quantification of vascular changes in macular telangiectasia type 2 with AngioTool software. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06487-w

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  • DOI: https://doi.org/10.1007/s00417-024-06487-w

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