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Sympathetic nervous activity and hemoglobin levels in de novo Parkinson’s disease

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Abstract

Purpose

Sympathetic nervous denervation may be associated with the development of anemia. We aimed to investigate the association between sympathetic nervous denervation and hemoglobin levels in patients with Parkinson’s disease (PD).

Methods

As indices of sympathetic nervous denervation, we investigated resting norepinephrine levels, increased norepinephrine levels after tilt-up, cardiac uptake of 123I-metaiodobenzylguanidine, supine blood pressure, and the degree of orthostatic hypotension in 132 patients with de novo PD.

Results

Older age, female sex, severe motor dysfunction, and lower body mass index were associated with decreased hemoglobin levels. After adjustment for these covariables, resting norepinephrine levels were negatively associated with hemoglobin levels. Hemoglobin levels were not associated with cardiac sympathetic denervation or orthostatic intolerance.

Conclusion

Hemoglobin levels in PD seem to be closely related to noradrenergic nervous activity and nigrostriatal dopaminergic degeneration. In contrast to expectations, decreased hemoglobin levels were associated with increased whole-body sympathetic nervous activity in PD.

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References

  1. Hirsch E, Graybiel AM, Agid YA (1998) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson’s disease. Nature 334:345–348

    Article  Google Scholar 

  2. Logroscino G, Chen H, Wing A, Ascherio A (2006) Blood donations, iron stores, and risk of Parkinson’s disease. Mov Disord 21:835–838

    Article  Google Scholar 

  3. Savica R, Grossardt BR, Carlin JM, Icen M, Bower JH, Ahlskog JE, Maraganore DM, Steensma DP, Rocca WA (2009) Anemia or low hemoglobin levels preceding Parkinson disease: a case-control study. Neurology 73:1381–1387

    Article  CAS  Google Scholar 

  4. Hong CT, Huang YH, Liu HY, Chiou HY, Chan L, Chien LN (2016) Newly diagnosed anemia increases risk of Parkinson’s disease: a population-based cohort study. Sci Rep 6:29651

    Article  CAS  Google Scholar 

  5. Rozani V, Giladi N, Gurevich T, EL-Ad B, Tsamir J, Hemo B, Peretz C (2019) Anemia in men and increased Parkinson’s disease risk: a population-based large scale cohort study. Parkinsonism Relat Disord 5:2–9. https://doi.org/10.1016/j.parkreldis.2019.03.010

    Article  Google Scholar 

  6. Madden KS (2017) Sympathetic neural-immune interactions regulate hematopoiesis, thermoregulation and inflammation in mammals. Dev Comp Immunol 66:92–97

    Article  CAS  Google Scholar 

  7. Biaggioni I, Robertson D, Krantz S, Jones M, Haile V (1994) The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann Intern Med 121:181–186

    Article  CAS  Google Scholar 

  8. Winkler AS, Marsden J, Parton M, Watkins PJ, Chaudhuri KR (2001) Erythropoietin deficiency and anaemia in multiple system atrophy. Mov Disord 16:233–239

    Article  CAS  Google Scholar 

  9. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease. A clinic-pathological study of 100 cases. J Neurol Neurosurg Psychiatr 55:181–184

    Article  CAS  Google Scholar 

  10. Spiegel J, Hellwig D, Samnick S, Jost W, Möllers MO, Fassbender K, Kirsch CM, Dillmann U (2007) Striatal FP-CIT uptake differs in the subtypes of early Parkinson’s disease. J Neural Transm 114:331–335

    Article  CAS  Google Scholar 

  11. Nagamachi S, Wakamatsu H, Kiyohara S, Fujita S, Futami S, Tamura S, Nakazato M, Yamashita S, Arita H, Nishii R, Kawai K (2008) Usefulness of rCBF analysis in diagnosing Parkinson’s disease: supplemental role with MIBG myocardial scintigraphy. Ann Nucl Med 22:557–564

    Article  Google Scholar 

  12. Fanciulli A, Jordan J, Biaggioni I, Calandra-Buonaura G, Cheshire WP, Cortelli P, Eschlboeck S, Grassi G, Hilz MJ, Kaufmann H, Lahrmann H, Mncia G, Mayer G, Norcliffe-Kaufmann L, Pavy-Le Traon A, Raj SR, Robertoson D, Rocha I, Struhal W, Thijs R, Tsioufis KP, van Dijk JG, Wenning GK (2018) Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS): Endorsed by the European Academy of Neurology (EAN) and the European Society of Hypertension (ESH). Clin Auton Res 28:355–362

    Article  Google Scholar 

  13. Gibbons CH, Freeman R (2015) Clinical implication of delayed orthostatic hypotension: a 10-year follow-up study. Neurology 85:1362–1367

    Article  Google Scholar 

  14. Takaku F, Hirashima K, Okinaka S (1961) Effect of bilateral section of the splanchnic nerve on erythropoiesis. Nature 191:500–501

    Article  CAS  Google Scholar 

  15. Vasamsetti SB, Florentin J, Coppin E, Stiekema LCA, Zheng KH, Nisar MU, Sembrat J, Levinthal DJ, Rojas M, Stroes ESG, Kim K, Dutta P (2018) Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation. Immunity 49:93–106.e7

    Article  CAS  Google Scholar 

  16. Lang E, Qadri SM, Lang F (2012) Killing me softly—suicidal erythrocyte death. Int J Biochem Cell Biol 44:1236–1243

    Article  CAS  Google Scholar 

  17. Méndez-Ferrer S, Lucas D, Battista M, Frenette PS (2008) Haematopoietic stem cell release is regulated by circadian oscillations. Nature 452:442–447

    Article  Google Scholar 

  18. Valbusa F, Labat C, Salvi P, Vivian ME, Hanon O, Benetos A, PARTAGE investigators (2012) Orthostatic hypotension in very old individuals living in nursing homes: the PARTAGE study. J Hypertens 30:53–60

    Article  CAS  Google Scholar 

  19. Szewczyk-krolikowski K, Tomlinson P, Nithi K, Wade-Martins R, Talbot K, Ben-Shlomo Y, Hu MT (2014) The influence of age and gender on motor and non-motor features of early Parkinson’s disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort. Parkinsonism Relat Disord 20:99–105

    Article  Google Scholar 

  20. Goldstein DS, Holmes C, Kopin IJ, Sharabi Y (2011) Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases. J Clin Invest 121:3320–3330

    Article  CAS  Google Scholar 

  21. Williams-Gray CH, Wijeyekoon R, Yarnall AJ, Lawson RA, Breen DP, Evans JR, Cummins GA, Duncan GW, Khoo TK, Burn DJ, Barker RA, ICICLE-PD study group (2016) Serum immune markers and disease progression in an incident Parkinson’s disease cohort (ICICLE-PD). Mov Disord 31:995–1003

    Article  CAS  Google Scholar 

  22. Petrosyan I, Blaison G, Andrès E, Federici L (2012) Anemia in the elderly: etiologic profile in a prospective cohort of 95 hospitalized patients. Eur J Intern Med 23:524–528

    Article  Google Scholar 

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Funding

There was no sponsorship or funding for this report.

Author information

Authors and Affiliations

  1. Department of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan

    Tadashi Umehara, Tomotaka Shiraishi, Takeo Sato, Hiromasa Matsuno, Teppei Komatsu, Shusaku Omoto, Hidetomo Murakami & Yasuyuki Iguchi

  2. Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan

    Tadashi Umehara, Hisayoshi Oka & Atsuo Nakahara

Authors
  1. Tadashi Umehara
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  2. Hisayoshi Oka
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  3. Atsuo Nakahara
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  4. Tomotaka Shiraishi
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  5. Takeo Sato
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  6. Hiromasa Matsuno
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  7. Teppei Komatsu
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  8. Shusaku Omoto
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  9. Hidetomo Murakami
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  10. Yasuyuki Iguchi
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Contributions

TU: designed and conceptualized study, major role in acquisition of data, analyzed data, interpreted data, drafted/revised the manuscript for intellectual content; HO: major role in acquisition of data, interpreted data, manuscript review; AN: major role in acquisition of data, manuscript review; TS: major role in acquisition of data, manuscript review; TS: major role in acquisition of data, manuscript review; HM: major role in acquisition of data, manuscript review; TK: major role in acquisition of data, manuscript review; SO: major role in acquisition of data, manuscript review; HM: major role in reviewing the manuscript; YI: major role in reviewing the manuscript.

Corresponding author

Correspondence to Tadashi Umehara.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study has been approved by the Ethics Committee of Jikei University School of Medicine and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All subjects gave written informed consent before enrollment.

Disclosures

Dr. Tadashi Umehara, Dr. Hisayoshi Oka, Dr. Atsuo Nakahara, Dr. Tomotaka Shiraishi, Dr. Takeo Sato, Dr. Hiromasa Matsuno, Dr. Teppei Komatsu, Dr. Shusaku Omoto, Dr. Hidetomo Murakami and Dr. Yasuyuki Iguchi report no disclosures.

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Umehara, T., Oka, H., Nakahara, A. et al. Sympathetic nervous activity and hemoglobin levels in de novo Parkinson’s disease. Clin Auton Res 30, 273–278 (2020). https://doi.org/10.1007/s10286-020-00668-3

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  • DOI: https://doi.org/10.1007/s10286-020-00668-3

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