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Association between serum uric acid and new onset and progression of chronic kidney disease in a Japanese general population: Iki epidemiological study of atherosclerosis and chronic kidney disease

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Abstract

Background

Although several risk factors for chronic kidney disease (CKD) have been proposed, it remains unclear whether elevated serum uric acid (SUA) is negatively association with kidney function. The aim of this study was to elucidate the association between SUA and new onset and progression of CKD in a Japanese general population.

Methods

This was a population-based retrospective cohort study using annual health checkup data of residents of Iki Island. A total of 5,507 adults (979 with CKD and 4,528 without) were included. The outcomes were new onset of CKD among participants without CKD at baseline, and progression of CKD among those with CKD. A Cox proportional hazards model was used to evaluate the association between SUA and new onset and progression of CKD.

Results

During mean follow-up of 4.6 years, 757 cases of new onset of CKD and 193 with progression of CKD were observed. SUA was significantly associated with new onset of CKD (adjusted hazard ratio 1.13, [95% confidence interval 1.03–1.24] per standard deviation [SD] increase in SUA). In contrast, SUA was not significantly associated with progression of CKD (hazard ratio 1.08, [0.92–1.27] per SD increase). Similar results were obtained when classifying uric acid as categorical.

Conclusion

SUA was significantly associated with increased risk for new onset of CKD, but not with progression of CKD among a Japanese general population.

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Acknowledgements

We thank Richard Robins, PhD, from Edanz Group (https://en-author-services.edanz.com/ac) for editing a draft of this manuscript. This work was supported by JSPS KAKENHI Grant Numbers 18K17404 and 19H03912.

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Authors and Affiliations

  1. Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Kazuhiro Tada, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno, Kosuke Masutani & Hitoshi Nakashima

  2. Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma Jonan-ku, Fukuoka, 814-0180, Japan

    Kazuhiro Tada, Toshiki Maeda, Shunsuke Funakoshi, Atsushi Satoh, Miki Kawazoe, Chikara Yoshimura & Hisatomi Arima

  3. Nagasaki Prefecture Iki Hospital, Iki, Japan

    Shigeaki Mukoubara

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  1. Kazuhiro Tada
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Correspondence to Toshiki Maeda.

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Tada, K., Maeda, T., Takahashi, K. et al. Association between serum uric acid and new onset and progression of chronic kidney disease in a Japanese general population: Iki epidemiological study of atherosclerosis and chronic kidney disease. Clin Exp Nephrol 25, 751–759 (2021). https://doi.org/10.1007/s10157-021-02042-7

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  • DOI: https://doi.org/10.1007/s10157-021-02042-7

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