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Cardiac output response to exercise in patients before allogenic hematopoietic stem cell transplantation

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Abstract

Introduction

High-dose chemotherapy for remission induction can induce cardiac toxicity prior to hematopoietic stem cell transplantation (HSCT). However, the details of cardiac function in patients undergoing HSCT are unclear, particularly during exercise. The aim of present study was to evaluate cardiac output responses to exercise in patients after high-dose chemotherapy before HSCT compared with in age-matched healthy controls.

Methods

Twenty-nine patients before HSCT (age 44.6 ± 15.2 years) and 13 controls (45.8 ± 16.0 years) performed the 6-min walk test (6MWT). Cardiac output (CO), stroke volume (SV), heart rate (HR), and cardiac index (CI) were continuously measured during the 6MWT using the noninvasive thoracic impedance method.

Results

No significant difference was observed in the six-minute walk distance (6MD) between the two groups. SV, CO, and CI both at rest and the end of the 6MWT in the patients were significantly lower, compared with the controls, but there was no significant difference in HR. In all subjects, the 6MD was positively correlated with SV, CO, CI, and HR after the 6MWT.

Conclusion

These findings suggest that cardiac output response to exercise indicates exercise intolerance, which may not be detected by 6MD in patients before HSCT.

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Acknowledgements

The authors would like thank Azusa Yoshida for her help in collecting data.

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Authors and Affiliations

  1. Department of Rehabilitation, Kanazawa University Hospital, Takaramachi 13-1, Kanazawa, Ishikawa, 920-8641, Japan

    Shinya Yoshida & Tetsutaro Yahata

  2. School of Health Sciences, Kanazawa University, Kodatsuno 5-11-80, Kanazawa, Ishikawa, 920-0942, Japan

    Fujiko Someya

Authors
  1. Shinya Yoshida
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  2. Fujiko Someya
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  3. Tetsutaro Yahata
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Corresponding author

Correspondence to Shinya Yoshida.

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Yoshida, S., Someya, F. & Yahata, T. Cardiac output response to exercise in patients before allogenic hematopoietic stem cell transplantation. Int J Clin Oncol 23, 1173–1177 (2018). https://doi.org/10.1007/s10147-018-1315-2

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  • DOI: https://doi.org/10.1007/s10147-018-1315-2

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