Abstract
Purpose
Patients' physiological functions and health-related quality of life (QOL) are useful for planning physical therapy after allogeneic hematopoietic stem-cell transplantation (allo-HSCT), but have not been extensively examined prior to transplantation. We investigated whether physiological functions and health-related QOL were reduced in patients before undergoing allo-HSCT.
Methods
All patients (n = 110) who underwent allo-HSCT between May 2007 and April 2010 at Hyogo College of Medicine Hospital were included in this study and evaluated for hand-grip and knee-extensor strength; 6-min walk test (6MWT) and health-related QOL (SF-36) were also used for evaluation.
Results
Grip strength, knee-extensor strength, 6MWT, and all eight SF-36 health-related QOL subscale scores significantly decreased in HSCT patients compared to population norms (all, P < 0.01). Health-related QOL is associated with various confounding factors such as fatigue and sex. Loss of physiological function is also associated with confounding factors; one such association was found between skeletal muscle strength and previous HSCT treatment.
Conclusion
Health-related QOL and loss of physiological function have a variety confounding factors. Patients scheduled for HSCT may have physiological weaknesses prior to transplant, which need to be considered when planning an exercise regimen during and after transplantation.
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Acknowledgments
The authors are grateful to the study participants, the physiotherapists at the Rehabilitation Department, and the physicians at the Division of Hematology in Hyogo College of Medicine Hospital.
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The authors declare no conflict of interest.
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Morishita, S., Kaida, K., Ikegame, K. et al. Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation. Support Care Cancer 20, 821–829 (2012). https://doi.org/10.1007/s00520-011-1156-2
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DOI: https://doi.org/10.1007/s00520-011-1156-2