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Risk of cerebro- and cardiovascular disease in patients with scrub typhus

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Abstract

We analyzed the National Health Insurance Service-National Sample Cohort (NHIS-NSC) data to evaluate whether scrub typhus infection is associated with increased risk of subsequent cardio- and cerebrovascular disease. Compared with the control group, the scrub typhus group showed a greater incidence rate of cardiovascular disease (14.5 vs. 9.0 cases per 1000 person-years). In contrast, the scrub typhus group showed no difference in incidence rate of cerebrovascular disease (12.0 vs. 13.3 cases per 1000 person-years). Based on the NHIS-NSC data, patients with scrub typhus are at greater risk of developing cardiovascular disease long term compared with that of the general population.

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References

  1. Ross R (1999) Atherosclerosis - an inflammatory disease. N Engl J Med 340(2):115–126

    Article  CAS  Google Scholar 

  2. Chung WS, Lin CL, Hsu WH, Kao CH (2014) Scrub typhus increases the risk of developing acute coronary syndrome: a nationwide cohort study. Heart 100(23):1844–1850

    Article  Google Scholar 

  3. Smeeth L, Thomas SL, Hall AJ, Hubbard R, Farrington P, Vallance P (2004) Risk of myocardial infarction and stroke after acute infection or vaccination. N Engl J Med 351(25):2611–2618

    Article  CAS  Google Scholar 

  4. Player MS, Mainous AG 3rd, Everett CJ, Diaz VA, Knoll ME, Wright RU (2014) Chlamydia pneumoniae and progression of subclinical atherosclerosis. Eur J Prev Cardiol 21(5):559–565

    Article  Google Scholar 

  5. Udell JA, Zawi R, Bhatt DL, Keshtkar-Jahromi M, Gaughran F, Phrommintikul A, Ciszewski A, Vakili H, Hoffman EB, Farkouh ME, Cannon CP (2013) Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis. JAMA 310(16):1711–1720

    Article  CAS  Google Scholar 

  6. Epstein SE, Zhu J, Najafi AH, Burnett MS (2009) Insights into the role of infection in atherogenesis and in plaque rupture. Circulation 119(24):3133–3141

    Article  CAS  Google Scholar 

  7. Chiu B, Viira E, Tucker W, Fong IW (1997) Chlamydia pneumoniae, cytomegalovirus, and herpes simplex virus in atherosclerosis of the carotid artery. Circulation 96(7):2144–2148

    Article  CAS  Google Scholar 

  8. Chung MH, Lee JS, Baek JH, Kim M, Kang JS (2012) Persistence of Orientia tsutsugamushi in humans. J Korean Med Sci 27(3):231–235

    Article  CAS  Google Scholar 

  9. Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci 83(4):1140–1144

    Article  CAS  Google Scholar 

Download references

Funding

This research was supported by the Basic Science Research Programs (NRF-2015R1D1A1A01060251 and 2018R1D1A3B07049557) of the National Research Foundation of Korea, which are funded by the Ministry of Education. This study was supported by research funds from Biomedical Research Institute, Chonbuk National University Hospital, and from Chonbuk National University in 2019.

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Author notes

  1. Lae Young Jung and Juhyung Lee contributed equally to this work.

Authors and Affiliations

  1. Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea

    Lae Young Jung, Mir Jeon, Joo-Hee Hwang & Chang-Seop Lee

  2. Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Republic of Korea

    Lae Young Jung, Juhyung Lee, Joo-Hee Hwang & Chang-Seop Lee

  3. Department of Preventive Medicine, Chonbuk National University, Jeonju, Republic of Korea

    Juhyung Lee

  4. Department of Preventive Medicine, Konyang University College of Medicine, Daejeon, Republic of Korea

    Jee-Young Hong

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  1. Lae Young Jung
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  2. Juhyung Lee
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  3. Mir Jeon
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  4. Joo-Hee Hwang
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  6. Chang-Seop Lee
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Corresponding authors

Correspondence to Jee-Young Hong or Chang-Seop Lee.

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The authors declare that they have no conflict of interest.

Ethical approval and informed consent

The Institutional Review Board of Konyang University approved the study protocol with exemption of the requirement for informed consent (approval No. KYU-2018-011-01).

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Jung, L.Y., Lee, J., Jeon, M. et al. Risk of cerebro- and cardiovascular disease in patients with scrub typhus. Eur J Clin Microbiol Infect Dis 39, 451–454 (2020). https://doi.org/10.1007/s10096-019-03743-4

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  • DOI: https://doi.org/10.1007/s10096-019-03743-4

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