Skip to main content

Advertisement

SpringerLink
Log in

Association between ZNF184 and symptoms of Parkinson’s disease in southern Chinese

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Study objectives

The aim was to investigate the association between ZNF184 and symptoms of Parkinson’s disease (PD) in southern Chinese.

Methods

A total of 241 PD patients were recruited in this study. All patients were evaluated by Sniffin’ Sticks 16 (SS-16), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson’s disease Questionnaire (PDQ-39) and MDS-Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded.

Results

There was association of rapid eye movement sleep behavior disorder (RBD) under additive, dominant and overdominant model (p 0.039, additive; p 0.028, dominant; p 0.044, overdominant). We also found the association of excessive daytime sleepiness under the dominant model, the association of urgent urination or urinary incontinence under the recessive model and the association of sensitive to hot under the overdominant model (excessive daytime sleepiness: p 0.032, dominant; p 0.038, dominant; urgent urination or urgent incontinence: p 0.027, recessive; sensitive to hot: p, 0.027, overdominant).

Conclusions

ZNF184 rs9468199 was associated with the presence of RBD, excessive daytime sleepiness, urgent urination or urgent incontinence and sensitive to hot.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Abbreviations

CI:

confidence interval

MDS:

movement disorders society

MMSE:

Mini-Mental State Examination

MoCA:

Montreal Cognitive Assessment

NMSS:

non-motor symptoms scale

OR:

odds ratio

PD:

Parkinson’s disease

PDQ-39:

39-item Parkinson’s disease Questionnaire

RBD:

rapid eye movement sleep behavior disorder

RLS:

restless legs syndrome

SCOPA-AUT:

scales for Outcomes in Parkinson’s disease-autonomic questionnaire

SS-16:

Sniffin’ Sticks 16

UPDRS:

unified Parkinson’s disease rating scale

References

  1. Kalia LV, Lang AE (2015) Parkinson’s disease. Lancet 386(9996):896–912. https://doi.org/10.1016/s0140-6736(14)61393-3

    Article  CAS  PubMed  Google Scholar 

  2. Bene R, Antic S, Budisic M, Lisak M, Trkanjec Z, Demarin V, Podobnik-Sarkanji S (2009) Parkinson’s disease. Acta Clin Croat 48(3):377–380

    PubMed  Google Scholar 

  3. Blanca Ramirez M, Madero-Perez J, Rivero-Rios P, Martinez-Salvador M, Lara Ordonez AJ, Fernandez B, Fdez E, Hilfiker S (2017) LRRK2 and Parkinson’s disease: from lack of structure to gain of function. Curr Protein Pept Sci 18(7):677–686. https://doi.org/10.2174/1389203717666160311121748

    Article  CAS  PubMed  Google Scholar 

  4. Siddiqui IJ, Pervaiz N, Abbasi AA (2016) The Parkinson disease gene SNCA: evolutionary and structural insights with pathological implication. Sci Rep 6:24475. https://doi.org/10.1038/srep24475

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Koros C, Simitsi A, Stefanis L (2017) Genetics of Parkinson’s disease: genotype-phenotype correlations. Int Rev Neurobiol 132:197–231. https://doi.org/10.1016/bs.irn.2017.01.009

    Article  PubMed  Google Scholar 

  6. Gaig C, Vilas D, Infante J, Sierra M, Garcia-Gorostiaga I, Buongiorno M, Ezquerra M, Marti MJ, Valldeoriola F, Aguilar M, Calopa M, Hernandez-Vara J, Tolosa E (2014) Nonmotor symptoms in LRRK2 G2019S associated Parkinson’s disease. PLoS One 9(10):e108982. https://doi.org/10.1371/journal.pone.0108982

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Chang D, Nalls MA, Hallgrimsdottir IB, Hunkapiller J, van der Brug M, Cai F, Kerchner GA, Ayalon G, Bingol B, Sheng M, Hinds D, Behrens TW, Singleton AB, Bhangale TR, Graham RR (2017) A meta-analysis of genome-wide association studies identifies 17 new Parkinson’s disease risk loci. Nat Genet 49(10):1511–1516. https://doi.org/10.1038/ng.3955

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Li G, Cui S, Du J, Liu J, Zhang P, Fu Y, He Y, Zhou H, Ma J, Chen S (2018) Association of GALC, ZNF184, IL1R2 and ELOVL7 with Parkinson’s disease in Southern Chinese. Front Aging Neurosci 10:402. https://doi.org/10.3389/fnagi.2018.00402

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Goldwurm S, Menzies ML, Banyer JL, Powell LW, Jazwinska EC (1997) Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3. Genomics 40(3):486–489. https://doi.org/10.1006/geno.1996.4583

    Article  CAS  PubMed  Google Scholar 

  10. Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30(12):1591–1601. https://doi.org/10.1002/mds.26424

    Article  PubMed  Google Scholar 

  11. Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stern MB, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, van Hilten JJ, LaPelle N (2008) Movement disorder society-sponsored revision of the unified Parkinson’s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 23(15):2129–2170. https://doi.org/10.1002/mds.22340

    Article  PubMed  Google Scholar 

  12. Chen W, Chen S, Kang WY, Li B, Xu ZM, Xiao Q, Liu J, Wang Y, Wang G, Chen SD (2012) Application of odor identification test in Parkinson’s disease in China: a matched case-control study. J Neurol Sci 316(1–2):47–50. https://doi.org/10.1016/j.jns.2012.01.033

    Article  PubMed  Google Scholar 

  13. Shen SS, Shen Y, Xiong KP, Chen J, Mao CJ, Huang JY, Li J, Han F, Liu CF (2014) Validation study of REM sleep behavior disorder questionnaire-Hong Kong (RBDQ-HK) in East China. Sleep Med 15(8):952–958. https://doi.org/10.1016/j.sleep.2014.03.020

    Article  PubMed  Google Scholar 

  14. Mandaviya PR, Joehanes R, Aissi D, Kuhnel B, Marioni RE, Truong V, Stolk L, Beekman M, Bonder MJ, Franke L, Gieger C, Huan T, Ikram MA, Kunze S, Liang L, Lindemans J, Liu C, McRae AF, Mendelson MM, Muller-Nurasyid M, Peters A, Slagboom PE, Starr JM, Tregouet DA, Uitterlinden AG, van Greevenbroek MMJ, van Heemst D, van Iterson M, Wells PS, Yao C, Deary IJ, Gagnon F, Heijmans BT, Levy D, Morange PE, Waldenberger M, Heil SG, van Meurs JBJ (2017) Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes. PLoS One 12(10):e0182472. https://doi.org/10.1371/journal.pone.0182472

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Garcia S, Cano-Martinez LJ, Coral-Vazquez RM, Coronel-Perez A, Gomez-Diaz B, Toledo-Lozano CG, Gallegos-Arreola MP, Davila-Maldonado L, Jimenez-Hernandez DA, Alcaraz-Estrada SL, Lopez-Hernandez LB (2017) Analysis of the rs13306560 functional variant in the promoter region of the MTHFR gene in sporadic Parkinson’s disease. Neuro Endocrinol Lett 38(4):257–260

    CAS  PubMed  Google Scholar 

  16. Liao Q, Li NN, Mao XY, Chang XL, Zhao DM, Zhang JH, Yu WJ, Tan EK, Peng R (2014) MTHFR C677T variant reduces risk of sporadic Parkinson’s disease in ethnic Chinese. Acta Neurol Scand 130(1):e30–e34. https://doi.org/10.1111/ane.12245

    Article  CAS  PubMed  Google Scholar 

  17. Liu L, Zhang L, Guo L, Yu Q, Li H, Teng J, Xie A (2018) MTHFR C677T and A1298C polymorphisms may contribute to the risk of Parkinson’s disease: a meta-analysis of 19 studies. Neurosci Lett 662:339–345. https://doi.org/10.1016/j.neulet.2017.10.060

    Article  CAS  PubMed  Google Scholar 

  18. Vallelunga A, Pegoraro V, Pilleri M, Biundo R, De Iuliis A, Marchetti M, Facchini S, Formento Dojot P, Antonini A (2014) The MTHFR C677T polymorphism modifies age at onset in Parkinson’s disease. Neurol Sci 35(1):73–77. https://doi.org/10.1007/s10072-013-1545-z

    Article  PubMed  Google Scholar 

  19. Yuan L, Song Z, Deng X, Xiong W, Yang Z, Deng H (2016) Association of the MTHFR rs1801131 and rs1801133 variants in sporadic Parkinson’s disease patients. Neurosci Lett 616:26–31. https://doi.org/10.1016/j.neulet.2016.01.031

    Article  CAS  PubMed  Google Scholar 

  20. Zahra C, Tabone C, Camilleri G, Felice AE, Farrugia R, Bezzina Wettinger S (2016) Genetic causes of Parkinson’s disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR. BMC Med Genet 17(1):65. https://doi.org/10.1186/s12881-016-0327-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Hashida H, Goto J, Zhao N, Takahashi N, Hirai M, Kanazawa I, Sakaki Y (1998) Cloning and mapping of ZNF231, a novel brain-specific gene encoding neuronal double zinc finger protein whose expression is enhanced in a neurodegenerative disorder, multiple system atrophy (MSA). Genomics 54(1):50–58. https://doi.org/10.1006/geno.1998.5516

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank all the patients who participated in this study.

Funding

This study was funded by the National Natural Science Foundation of China [grant numbers 81601010, 81701039]; Young Excellent Talents in Tongji University (22120180604), Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai [Grant No. PWZxq2017–08] and the Outstanding Leaders Training Program of Pudong new area health system of Shanghai [Grant No. PWRl2018–01].

Author information

Authors and Affiliations

  1. Department of Neurology, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China

    Bei Zhang, Can Cui, Hongxiang Yu & Gang Li

Authors
  1. Bei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Can Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hongxiang Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gang Li.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the ethic committee of shanghai East hospital affiliated to Tongji University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study. Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, B., Cui, C., Yu, H. et al. Association between ZNF184 and symptoms of Parkinson’s disease in southern Chinese. Neurol Sci 41, 2121–2126 (2020). https://doi.org/10.1007/s10072-020-04309-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-020-04309-5

Keywords

Search

Navigation