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Does B12 deficiency lead to change in brain metabolites in pediatric population? A MR spectroscopy study

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Abstract

Objectives

The aim of this study is to examine metabolite changes in different brain regions of the children with vitamin B12 deficiency disease using MR spectroscopy.

Methods

Eighteen children with serum vit. B12 deficiency and 12 healthy volunteer children were included in the study. All children were examined with single-voxel spectroscopy examination via 1.5-Tesla MRI. The spectra were obtained from the left frontal periventricular white matter, left lentiform nucleus and left cerebellar hemisphere. The comparisons between patient group and control group were made with ratios calculated as NAA/Cr, Cho/Cr, mI/Cr, and Glx/Cr. All brain images were also examined in terms of brain atrophy, abnormal brain parenchyma intensity changes, or myelination status.

Results

The children were between 3 months and 16 years old in the patient group, and between 3 months and 15 years old in the control group. There were no statistical differences in terms of metabolite ratios in the three different brain regions between the patients and control group. In two patients, periventricular white matter hyperintensities were observed. In four patients, brain atrophy was detected.

Discussion

MR spectroscopy examination demonstrated that there were no statistical differences in terms of all metabolite ratios in left frontal periventricular white matter, left lentiform nucleus and left cerebellar hemisphere.

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Authors and Affiliations

  1. Department of Radiology, Harran University School of Medicine, Sanliurfa-Mardin Highway 18.Km, 63300, Sanliurfa, Turkey

    Dilek Sen Dokumaci

  2. Department of Radiology, Sanliurfa Training and Research Hospital, 63250, Sanliurfa, Turkey

    Ferit Dogan

  3. Department of Pediatrics, Sanliurfa Training and Research Hospital, 63250, Sanliurfa, Turkey

    Suleyman Geter & Veysi Almaz

  4. Department of Pediatrics, Harran University School of Medicine, 63300, Sanliurfa, Turkey

    Mustafa Calik

Authors
  1. Dilek Sen Dokumaci
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  2. Ferit Dogan
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  3. Suleyman Geter
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  4. Veysi Almaz
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  5. Mustafa Calik
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Correspondence to Dilek Sen Dokumaci.

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This study has been presented as an e-poster at the annual meeting of European Society of Neuroradiology (ESNR), Malmö, Sweden, September 2017.

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Dokumaci, D.S., Dogan, F., Geter, S. et al. Does B12 deficiency lead to change in brain metabolites in pediatric population? A MR spectroscopy study. Neurol Sci 40, 2319–2324 (2019). https://doi.org/10.1007/s10072-019-03990-5

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  • DOI: https://doi.org/10.1007/s10072-019-03990-5

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