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Efficacy of analgesia promoted by lidocaine and articaine in third molar extraction surgery. A split-mouth, randomized, controlled trial

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Abstract

Purpose

The aim of this study was to compare the analgesic efficacy of 4% articaine associated with epinephrine (1:100,000), and 2% lidocaine associated with epinephrine (1:100,000) in third molar extraction surgery.

Methods

Sixty patients who underwent surgeries to extract upper and lower third molars were included in this split-mouth, double-blind, randomized, controlled trial. The groups in this study were divided according to the anesthetic solution used to provide local anesthesia during extraction of upper and lower third molars: (1) 4% articaine associated with epinephrine (1:100,000); (2) 2% lidocaine associated with epinephrine (1:100,000). The time to the beginning and end of the sensation of analgesia, pain sensation according to the VAS scale, and number of anesthetic tubes necessary for supplementation were analyzed.

Results

It was found that the onset time for analgesia was shorter on the side anesthetized with articaine compared to the side anesthetized with lidocaine (122.1 ± 52.90 s vs. 144.5 ± 68.85 s) (p < 0.05). In addition, the number of tubes used for anesthetic supplementation was also reduced on the articaine side compared to the lidocaine side (0.26 ± 0.48 vs. 0.50 ± 0.75) (p < 0.05). There were no differences between the anesthetic solutions in the other evaluated parameters.

Conclusion

It can be concluded that the use of 4% articaine associated with epinephrine (1:100,000) reduced the time of onset of analgesia and the necessity for anesthetic supplementation in third molar extraction surgeries compared to the use of 2% lidocaine associated with epinephrine (1:100,000).

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Data Availability

The datasets generated and/or analysed during the current study is available from corresponding author on request.

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Funding

This study was financed by the Brazilian agencies CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, 426954/2018–1) and FAPEMIG (Fundação de Apoio a Pesquisa do Estado de Minas Gerais—APQ-02211–21).

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Authors and Affiliations

  1. Universidade Federal de Uberlândia - UFU, School of Dentistry, Department of Periodontology, Pará, Av., 1760-1844 - Umuarama, Uberlândia, MG, 38405-320, Brazil

    Samara de Souza Santos, Mariana Silva Bonatto, Pedro Gomes Junqueira Mendes, Ana Vitória Borges Martins, Davisson Alves Pereira & Guilherme José Pimentel Lopes de Oliveira

Authors
  1. Samara de Souza Santos
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  2. Mariana Silva Bonatto
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  3. Pedro Gomes Junqueira Mendes
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  4. Ana Vitória Borges Martins
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  5. Davisson Alves Pereira
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  6. Guilherme José Pimentel Lopes de Oliveira
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Contributions

Study design and concept: GJO, DAP, MSB; methodology: SSS, PGJM, AVBM, DAP, MSB; data obtention: SSS, PGJM, AVBM; data curation: GJO; writing of the paper: SSS, DAP, GJO; approval of the final version: all the authors; project supervision: GJO.

Corresponding author

Correspondence to Guilherme José Pimentel Lopes de Oliveira.

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Ethics approval

This study was approved by the Ethics Committee for Research of the Federal University of Uberlândia (CAAE: 49164821.0.0000.5152). The study was conducted in accordance with the precepts of the Declaration of Helsinki. The study was previously registered in the Brazilian Clinical Trials Registry (REBEC—U1111-1269–7450).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Competing interests

The authors declare no competing interests.

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de Souza Santos, S., Bonatto, M.S., Mendes, P.G.J. et al. Efficacy of analgesia promoted by lidocaine and articaine in third molar extraction surgery. A split-mouth, randomized, controlled trial. Oral Maxillofac Surg 28, 919–924 (2024). https://doi.org/10.1007/s10006-024-01223-4

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