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Prevalence and associated factors of myofascial pain in orthognathic patients with skeletal class II malocclusion

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Abstract

Orthognathic patients with skeletal class II malocclusion frequently suffer from myofascial pain (MP).

Purpose

This study aimed to evaluate the prevalence and associated factors of MP in these patients.

Methods

This cross-sectional study was performed in adult patients with skeletal Class II malocclusion requiring orthognathic surgery. They were divided according to the presence or absence of MP. The predictor variables were craniofacial morphology, sex, temporomandibular disorders, chronic pain, depression, and polymorphisms of dopamine receptors DRD2 (rs6275 and rs6276) and ANKK1 (rs1800497) genes. Data were submitted to statistical analyses using the linear regression model and Poisson regression with a significance level of 0.05.

Results

Sixty-five individuals were selected, of which 50 (76.92%) were females. A total of 21 (32.3%) patients had MP. Individuals with MP showed a decrease in the mandible gonial angle (p = 0.042) and an increased risk of having temporomandibular joint (TMJ) disc displacement (p = 0.003), TMJ pain (p = 0.030), chronic pain (p = 0.001), and severe depression (p = 0.015). Additionally, individuals carrying AA and AG genotypes in rs6275, and CC genotype in rs6276, were more likely to have MP (p < 0.05).

Conclusion

In this study, 32.3% of skeletal class II orthognathic patients had MP, which was associated with a decreased gonial angle, TMJ disc displacement, TMJ pain, chronic pain, depression, and polymorphisms in the DRD2 gene.

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Author information

Authors and Affiliations

  1. School of Health Sciences, Positivo University, Curitiba, PR, Brazil

    Lucas Caetano Uetanabaro, Jennifer Tsi Gerber, Katheleen Miranda dos Santos & Michelle Nascimento Meger

  2. Department of Stomatology, Federal University of Parana, 632 Prefeito Lothário Meissner Avenue, Curitiba, PR, 80210-170, Brazil

    Delson João da Costa, Aline Monise Sebastiani & Rafaela Scariot

  3. Department of Pediatric Dentistry, Ribeirão Preto Dental School, University of Sao Paulo, Ribeirão Preto, SP, Brazil

    Erika Calvano Küchler

Authors
  1. Lucas Caetano Uetanabaro
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  2. Jennifer Tsi Gerber
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  3. Katheleen Miranda dos Santos
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  4. Michelle Nascimento Meger
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  5. Delson João da Costa
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  6. Erika Calvano Küchler
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  7. Aline Monise Sebastiani
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  8. Rafaela Scariot
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Contributions

All authors contributed to the study conception and design. Lucas Caetano Uetanabaro contributed to investigation, data curation, writing the original draft. Jennifer Tsi Gerber contributed to statistical analysis, reviewing and editing the manuscript. Kathleen Miranda dos Santos contributed to data collection, data curation and reviewing the manuscript. Michelle Nascimento Meger performed the data curation and genotyping. Delson João da Costa contributed to the investigation, project administration, and supervision. Erika Calvano Küchler contributed to laboratorial analysis, funding acquisition, and reviewing the manuscript. Aline Monise Sebastiani and Rafaela Scariot contributed to project administration, funding acquisition, and reviewing the manuscript. All authors gave final approval and agreed to account for all aspects of the work.

Corresponding author

Correspondence to Aline Monise Sebastiani.

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Ethics approval

This project was approved by the local Ethics Committee under protocol number CAAE 80846317.8.0000.0093.

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Informed consent was obtained from all individual participants included in the study.

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The authors affirm that human research participants provided informed consent for publication.

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The authors declare no competing interests.

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Uetanabaro, L.C., Gerber, J.T., dos Santos, K.M. et al. Prevalence and associated factors of myofascial pain in orthognathic patients with skeletal class II malocclusion. Oral Maxillofac Surg 27, 25–31 (2023). https://doi.org/10.1007/s10006-022-01046-1

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  • DOI: https://doi.org/10.1007/s10006-022-01046-1

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