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The relationship between periodontal status and hyperglycemia after kidney transplantation

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Abstract

Objectives

Several factors have been associated with hyperglycemia after kidney transplantation (KTx), including systemic inflammation. This study aimed to investigate the relationship between periodontal status and hyperglycemia in KTx patients.

Materials and methods

Forty-four KTx patients were included in this cross-sectional study. Periodontitis severity was categorized into stage I to IV. Fasting blood glucose (FBG) was measured, and hyperglycemia was analyzed at different FBG cutoff points (100 mg/dL, 110 mg/dL, 120 mg/dL, 126 mg/dL, 140 mg/dL). Age, history of smoking, prior type 2 diabetes (T2D), and prior cardiovascular disease (CVD) were considered cofounders. Multivariable logistic regression modelling was performed with periodontitis as the exposure and hyperglycemia as the outcome. Pathway analysis was performed with FBG as a continuous outcome.

Results

Periodontitis had increased odds of hyperglycemia from 120 mg/dL FBG cutoff, even after adjustment. In addition, periodontitis severity was positively associated with FBG level (β = 0.323, SE = 0.127, P = 0.011).

Conclusion

The findings suggest that periodontitis may be related to increase of hyperglycemia and FBG levels in KTx patients.

Clinical relevance

Periodontitis severity and cardiovascular disease were positively associated with FBG levels in KTx patients. Clinicians and patients should be aware of the potential benefit of periodontal care for better glycemic control management.

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Acknowledgements

The authors thank the hospital staff for their help with data collection.

Funding

This study was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Brasil (CAPES) [Finance Code 001 and PROCAD grant 88881.357834/2019–01].

Author information

Authors and Affiliations

  1. Dentistry Graduate Program, Federal University of Maranhão, Avenida Dos Portugueses, São Luís, 196665080-805, Brazil

    Samira V. Gomes, Vandilson Rodrigues, Danila L. Nunes-dos-Santos & Antonio L. A. Pereira

  2. School of Dentistry and Oral Health, Griffith University, Gold Coast, QLD, Australia

    Vandilson Rodrigues & Marco A. Peres

  3. National Dental Research Institute Singapore, National Dental Centre Singapore, Singapore, Singapore

    Marco A. Peres

  4. Oral Health ACP, Health Services and Systems Research Programme, Duke-NUS Medical School, Singapore, Singapore

    Marco A. Peres

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  1. Samira V. Gomes
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  2. Vandilson Rodrigues
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  4. Antonio L. A. Pereira
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Contributions

SVG, VPR, DLNS, and ALAP designed the study. SVG and D.L.N.S. contributed to data acquisition. VPR, ALAP, and MAP performed statistical analysis and interpreted the data. VPR, SVG, and MAP drafted the manuscript. All authors revised the manuscript and approved the final version.

Corresponding author

Correspondence to Vandilson Rodrigues.

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Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Research Ethics Committee of the Federal University of Maranhão (no. 1.572.392, CAAE: 55991616.6.0000.5087).

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All participants signed informed consent forms prior to the present study.

Conflict of interest

The authors declare no competing interests.

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Gomes, S.V., Rodrigues, V., Nunes-dos-Santos, D.L. et al. The relationship between periodontal status and hyperglycemia after kidney transplantation. Clin Oral Invest 26, 397–406 (2022). https://doi.org/10.1007/s00784-021-04011-6

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  • DOI: https://doi.org/10.1007/s00784-021-04011-6

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