Abstract
Introduction
This study estimated the direct medical costs of osteoporotic fractures from a large claims database in Korea.
Materials and methods
We compared the medical costs of hip, vertebral, and wrist fractures between two age groups (50–64 years vs 65 years and older). We used a generalized linear model to investigate the drivers of osteoporotic fracture medical costs.
Results
Hip fractures had the highest costs, regardless of age, followed by vertebral and wrist. The cost of hip fracture was USD 7285 for those aged 65 years and over and USD 6589 for those aged 50–64 years. The length of hospital days was higher in hip fracture patients, regardless of age, followed by vertebral and wrist. As the number of hospitalizations increased, the medical cost increased by 33.0% (p < 0.0001). Patients older than 65 years who were hospitalized for a fracture had a longer total length of hospital stay, compared to patients aged 50–64, regardlessness of the site of the fracture. The cost of treating fractures among those 65 years and older increased by 31.8% compared to those 50–64 years old (p < 0.0001). The direct medical costs increased by 8.6% as the number of fractures increased (p = 0.041).
Conclusions
We identified that osteoporotic fracture-related medical costs and hospitalization days increased with age. Interventions are effective in reducing fracture risk the potential to yield substantial cost savings.
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References
Sk L (2000) Treatment of osteoporosis. Korean J Med 58:698–703
Cho CH et al (2013) Comparative analysis between male and female osteoporotic compression fractures in elderly patients. Korean J Neurotrauma 9:131–134
Svedbom A et al (2018) Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures—results from the ICUROS. Osteoporos Int 29:557–566
Randell A et al (2000) Deterioration in quality of life following hip fracture: a prospective study. Osteoporos Int 11:460–466
Weycker D et al (2016) Hospitalizations for osteoporosis-related fractures: economic costs and clinical outcomes. Bone Rep 5:186–191
Budhia S et al (2012) Osteoporotic fractures. Pharmacoeconomics 30:147–170
Hansen L et al (2013) A health economic analysis of osteoporotic fractures: who carries the burden? Arch Osteopor 8:126
Statistic Korea (2017) 2017 elderly people statistics
Homepage, Bank of Korea. Economic Statistics System. Available from: http://ecos.bok.or.kr/flex/EasySearch.jsp?topCode=036Y001
Park C et al (2011) The incidence and residual lifetime risk of osteoporosis-related fractures in Korea. J Bone Miner Metab 29:744–751
Kim HY et al (2017) Healthcare costs of osteoporotic fracture in Korea: information from the national health insurance claims database, 2008–2011. J Bone Metab 24:125–133
Burge R et al (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res 22:465–475
Choi SH et al (2020) Incidence and management trends of osteoporotic vertebral compression fractures in South Korea: a nationwide population-based study. Asian Spine J 14:220
Kim J et al (2016) Economic burden of osteoporotic fracture of the elderly in South Korea: a national survey. Value Health Region Issues 9:36–41
Kim L et al (2013) Developing the inpatient sample for the National Health Insurance claims data. Health Policy Manag 23:152–161
Kim L, Kim J-A, Kim S (2014) A guide for the utilization of health insurance review and assessment service national patient samples. Epidemiol Health 36:2
Health Insurnace Review & Assessment Service (HIRA) Homepage., Heathcare Bigdata Hub page https://opendata.hira.or.kr/home.do
World Health Organization, International Classification of Diseases-10.https://www.who.int/classifications/icd/icdonlineversions/en/
World Health Organization, Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group [meeting held in Rome from 22 to 25 June 1992]. 1994.
Choi HJ et al (2012) Burden of osteoporosis in adults in Korea: a national health insurance database study. J Bone Miner Metab 30:54–58
Ha Y-C et al (2016) Current trends and future projections of hip fracture in South Korea using nationwide claims data. Osteoporos Int 27:2603–2609
Choi YJ et al (2012) The prevalence of osteoporosis in Korean adults aged 50 years or older and the higher diagnosis rates in women who were beneficiaries of a national screening program: the Korea National Health and Nutrition Examination Survey 2008–2009. J Bone Miner Res 27:1879–1886
Taguchi Y et al (2018) Treatment costs and cost drivers among osteoporotic fracture patients in Japan: a retrospective database analysis. Arch Osteopor 13:45
Farhat GN, Cauley JA (2008) The link between osteoporosis and cardiovascular disease. Clin Cases Miner Bone Metab 5:19
Lv X-L et al (2018) Association between osteoporosis, bone mineral density levels and Alzheimer’s disease: a systematic review and meta-analysis. Int J Gerontol 12:76–83
Nakchbandi IA (2014) Osteoporosis and fractures in liver disease: relevance, pathogenesis and therapeutic implications. World J Gastroenterol WJG 20:9427
Oei L et al (2016) Osteoporotic vertebral fractures as part of systemic disease. J Clin Densitomet 19:70–80
Inoue D, Watanabe R, Okazaki R (2016) COPD and osteoporosis: links, risks, and treatment challenges. Int J Chron Obstruct Pulmon Dis 11:637
Pan M-L et al (2017) Iron deficiency anemia as a risk factor for osteoporosis in Taiwan: a nationwide population-based study. Nutrients 9:616
Okazaki R, Watanabe R, Inoue D (2016) Osteoporosis associated with chronic obstructive pulmonary disease. J Bone Metab 23:111–120
Li C et al (2017) Meta-analysis of hypertension and osteoporotic fracture risk in women and men. Osteoporos Int 28:2309–2318
Oh HJ et al (2018) Osteoporosis and osteoporotic fractures in gastrointestinal disease. J Bone Metab 25:213–217
Friedman SM et al (2010) Dementia and hip fractures: development of a pathogenic framework for understanding and studying risk. Geriatr Orthopaed Surg Rehab 1:52–62
Handzlik-Orlik G et al (2016) Osteoporosis in liver disease: pathogenesis and management. Therap Adv Endocrinol Metab 7:128–135
Hu X et al (2019) Relationship between senile osteoporosis and cardiovascular and cerebrovascular diseases. Exp Therap Med 17:4417–4420
Gregori D, Petrinco M, Bo S, Desideri A, Merletti F, Pagano E (2011) Regression models for analyzing costs and their determinants in health care: an introductory review. Int J Qual Health Care 23:331–341
Ng VK, Cribbie RA (2019) The gamma generalized linear model, log transformation, and the robust Yuen-Welch test for analyzing group means with skewed and heteroscedastic data. Commun Stat Simul Comput 48:2269–2286
Yang Y et al (2015) Inpatient cost of treating osteoporotic fractures in mainland China: a descriptive analysis. ClinicoEcon Outcomes Res CEOR 7:205
Chang C-Y et al (2016) The mortality and direct medical costs of osteoporotic fractures among postmenopausal women in Taiwan. Osteoporos Int 27:665–676
Leslie W et al (2013) Direct healthcare costs for 5 years post-fracture in Canada. Osteoporos Int 24:1697–1705
Wu J et al (2019) Healthcare resource utilization and direct medical costs for patients with osteoporotic fractures in China. Value Health Region Issues 18:106–111
El AA et al (2017) Direct medical costs of hospital treatment of fractures of the upper extremity of the femur. Pan Afr. Med. J. 27:133–133
Ye Z, Lu H, Liu P (2017) Association between essential hypertension and bone mineral density: a systematic review and meta-analysis. Oncotarget 8:68916
Yang S et al (2014) Association between hypertension and fragility fracture: a longitudinal study. Osteoporos Int 25:97–103
Moayeri A et al (2017) Fracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysis. Ther Clin Risk Manag 13:455
Lee P-H et al (2016) Risk and clinical predictors of osteoporotic fracture in East Asian patients with chronic obstructive pulmonary disease: a population-based cohort study. PeerJ 4:e2634
Katz S, Weinerman S (2010) Osteoporosis and gastrointestinal disease. Gastroenterol Hepatol 6:506
Buizert PJ et al (2009) Lipid levels: a link between cardiovascular disease and osteoporosis? J Bone Miner Res 24:1103–1109
Downey CL et al (2017) Dementia and osteoporosis in a geriatric population: Is there a common link? World J Orthoped 8:412
Chang K-H et al (2014) Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis. Age 36:967–975
Wang H-K et al (2014) Increased risk of hip fractures in patients with dementia: a nationwide population-based study. BMC Neurol 14:175
Pisani P et al (2016) Major osteoporotic fragility fractures: risk factor updates and societal impact. World J Orthoped 7:171
Siris ES et al (2009) Impact of osteoporosis treatment adherence on fracture rates in North America and Europe. Am J Med 122:S3–S13
Robinson LS et al (2016) Direct, indirect and intangible costs of acute hand and wrist injuries: a systematic review. Injury 47:2614–2626
Reber KC et al (2018) Development of a risk assessment tool for osteoporotic fracture prevention: a claims data approach. Bone 110:170–176
Klotzbuecher CM et al (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721–739
Lindsay R et al (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285:320–323
Johnell O et al (2001) Acute and long-term increase in fracture risk after hospitalization for vertebral fracture. Osteoporos Int 12:207–214
Funding
This study was funded by Amgen Korea.
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EK and HYK conceived the study design and were in charge of the analysis. EK, GB, and HYK drafted and revised the manuscript. HY interpreted the data and revised the manuscript.
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EK, GB, and HYK have disclosed that they have no significant relationships with or financial interest in any commercial companies related to this study or article. HY is a full-time employee of Amgen. However, the authors had full control of the findings and the results presented without supervision or interference from the sponsors of the work.
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No ethical approval was required because this study involved the retrospective analysis of dataset in which the data were properly anonymised.
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Kim, E.G., Bae, G., Kwon, HY. et al. Aging and direct medical costs of osteoporotic fractures. J Bone Miner Metab 39, 589–597 (2021). https://doi.org/10.1007/s00774-020-01192-0
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DOI: https://doi.org/10.1007/s00774-020-01192-0