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Meta-analysis of hypertension and osteoporotic fracture risk in women and men

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Abstract

Summary

The present meta-analysis synthesized evidence from 10 articles encompassing 28 independent studies to verify the association between hypertension and osteoporotic fracture risk in women and men. Our results indicate that the risk of osteoporotic fracture among individuals with hypertension was higher than that among individuals without hypertension.

Introduction

Epidemiological studies have suggested that hypertension is related to osteoporotic fracture. However, discrepancies exist in the reported findings. In this study, a systematic review of relevant published articles was conducted to verify the association between hypertension and osteoporotic fracture risk in women and men.

Methods

PubMed (1953_October 5th, 2016) and Embase (1974_October 5th, 2016) were systematically searched for relevant articles. Odds ratios (ORs) and confidence intervals (CIs) were derived using random effect models. Categorical, subgroup, heterogeneity, publication bias, and meta-regression analyses were conducted.

Results

We analyzed 10 articles encompassing 28 independent studies, 1,430,431 participants, and 148,048 osteoporotic fracture cases. The risk of osteoporotic fracture among individuals with hypertension was higher (pooled OR = 1.33, 95% CI 1.25–1.40; I 2 = 72.3%, P < 0.001) than that among individuals without hypertension. The association between hypertension and fracture risk was slightly stronger in women (pooled OR = 1.52, 95% CI 1.30–1.79) than in men (pooled OR = 1.35, 95% CI 1.26–1.44). Studies conducted in Asia revealed results that were consistent with those of studies performed in Europe.

Conclusions

Hypertension is associated with osteoporotic fracture risk. However, the biological mechanisms underlying the effect of hypertension on osteoporotic fracture remain to be elucidated.

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Acknowledgements

The work was funded by the National Natural Science Foundation of China (Grant No. 81573235), Health and Family Commission of Wuhan Municipality (Grant No. WG15D20), and Wuhan Jiang’an District Science and Technology Bureau (Grant No. 2014111904).

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    C. Li, Y. Zeng, L. Tao & Q. Wang

  2. Hospital Infection Management Office, PUAI Hospital, Wuhan, 430032, China

    S. Liu

  3. Women and Children Medical Center of Jiang-an District, Wuhan, 430017, China

    Z. Ni

  4. Department of Medical Rehabilitation, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China

    Q. Huang

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  1. C. Li
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  2. Y. Zeng
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Correspondence to Q. Wang.

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Li, C., Zeng, Y., Tao, L. et al. Meta-analysis of hypertension and osteoporotic fracture risk in women and men. Osteoporos Int 28, 2309–2318 (2017). https://doi.org/10.1007/s00198-017-4050-z

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