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Neurophysiological examination combined with functional intraoperative navigation using TMS in patients with brain tumor near the central region—a pilot study

  • Original Article - Brain Tumors
  • Published:
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Abstract

Objective

Feasibility and value of non-invasive transcranial magnetic brain stimulation (TMS MAGVENTURE® MagPro R30 Denmark) for preoperative diagnosis and surgical planning of brain tumor operations in everyday clinical practice.

Methods

A prospective monocentric study was conducted, which included preoperative neurological and electrophysiological examination, TMS, and display of functional data in the navigation system (LOCALITE® TMS Navigator Germany). During surgery, the TMS data were correlated with the intraoperative monitoring (IOM). Twenty-four hours to 96 h and after at least 3 months, follow-ups with neurological, electrophysiological examinations and TMS stimulation were performed.

Results

Twenty-five patients with tumors in or near by the primary motor cortex region were included in the study. Twenty-one patients completed preoperative and first postoperative TMS and the neurological examination. Eight of 21 patients showed slight worsening of primary motor cortex function, 8 patients had an unchanged state, and 4 patients showed an improvement early after surgery. The changes of the electrophysiological examination like significant delay of the latency and/or reduced amplitudes matched well with the postoperative neurological outcome: if patients showed a worsening of the SEP’s and MEP’s, the postoperative results revealed deterioration.

Conclusion

A preoperatively performed TMS using the MAGVENTURE® MagPro R30 and the LOCALITE® TMS Navigator could be established in our clinical daily practice and allowed a safe and reliable mapping of the primary motor cortex in order to minimize the risk of postoperative neurological deficits and improve the neurological outcome of the patients.

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Author notes

  1. Katharina Köhlert and Katja Jähne contributed equally (joined-first author)

Authors and Affiliations

  1. Department of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany

    Katharina Köhlert, Katja Jähne & Jürgen Meixensberger

  2. Department of Neurology, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany

    Dorothee Saur

Authors
  1. Katharina Köhlert
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  2. Katja Jähne
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  3. Dorothee Saur
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  4. Jürgen Meixensberger
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Corresponding author

Correspondence to Katja Jähne.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Informed consent was obtained from all participants of the study.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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This article is part of the Topical Collection on Brain Tumors

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Köhlert, K., Jähne, K., Saur, D. et al. Neurophysiological examination combined with functional intraoperative navigation using TMS in patients with brain tumor near the central region—a pilot study. Acta Neurochir 161, 1853–1864 (2019). https://doi.org/10.1007/s00701-019-04004-1

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  • DOI: https://doi.org/10.1007/s00701-019-04004-1

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