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Heterotopic ossification is related to change in disc space angle after Prestige-LP cervical disc arthroplasty

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Abstract

Purpose

To investigate the influence of the immediate post-operative change in disc space angle relative to preoperation on heterotopic ossification (HO) occurrence following cervical disc arthroplasty (CDA) and on clinical and radiographic outcomes.

Methods

Eighty-four patients with single-level Prestige-LP arthroplasty were retrospectively reviewed. HO was assessed based on McAfee classification. Radiological parameters, including index disc space angle (DSA), functional spinal unit angle, cervical lordosis, segmental range of motion (SROM), migration and subsidence of the prosthesis, prosthesis–endplate coverage ratio, and complications, were evaluated. Clinical features and outcome scores were also evaluated.

Results

A significant association between immediate post-operative DSA change and HO occurrence was found. Patients with a more than 5° increase in immediate post-operative DSA lordosis had a significantly higher incidence of HO and more severe HO than patients with a less than 5° DSA increase after CDA. No correlation was observed between clinical outcomes and post-operative DSA increase or HO occurrence. Both groups maintained cervical sagittal alignment. However, patients with a more than 5° DSA increase exhibited larger anterior migration amount and lower prosthesis–endplate coverage ratio compared to a less than 5° increase in DSA, and more lordotic DSA and less SROM at the final follow-up compared with those at preoperation. No significant difference in other complications was found between the groups.

Conclusion

Patients with a more than 5° increase in immediate post-operative DSA showed adverse effects on HO formation. Overcorrected DSA was associated with poor prosthesis stability, inadequate endplate coverage, and limited SROM, although it did not affect the clinical outcomes.

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Acknowledgements

We thank Dr. Junfeng Zeng MD for his excellent assistance in collecting radiographs and related data. We also thank Drs. Zhiwei Guo and Tingkui Wu for their assistance and helpful suggestions for the statistical analysis.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, China

    Lingyun Hu, Hao Liu, Yang Meng, Yi Yang, Guangzhou Li, Chen Ding & Beiyu Wang

  2. Department of Orthopaedic Surgery, Nanchong Central Hospital, Second Clinical Medical College of North Sichuan Medical College, No. 97 Renmin South Rd, Nanchong, 637000, Sichuan, China

    Lingyun Hu

  3. Department of Radiology, Nanchong Central Hospital, Second Clinical Medical College of North Sichuan Medical College, No. 97 Renmin South Rd, Nanchong, 637000, Sichuan, China

    Jianying Zhang

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  1. Lingyun Hu
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Correspondence to Hao Liu.

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Electronic supplementary material

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Supplementary material 1 (PPTX 867 kb)

Supplemental Fig. 1 The ball and socket design of Prestige-LP cervical disc. (TIF 1257 kb)

586_2019_6053_MOESM3_ESM.tif

Supplemental Fig. 2 Compared to the relatively parallel lower endplate preparation (Above), the angled lower endplate preparation facilitates a larger open shell of the prosthesis toward the ventral aspect (Below). An arrowhead represents heterotopic ossification. FU, follow-up. (TIF 9447 kb)

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Hu, L., Zhang, J., Liu, H. et al. Heterotopic ossification is related to change in disc space angle after Prestige-LP cervical disc arthroplasty. Eur Spine J 28, 2359–2370 (2019). https://doi.org/10.1007/s00586-019-06053-7

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  • DOI: https://doi.org/10.1007/s00586-019-06053-7

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