Abstract
Dichlorvos (Dich), an organophosphate substance, is widely used as an insecticide with various side effects on humans. Petroselinum crispum with antioxidant properties (PC) has many therapeutic benefits. This study examines the detoxification feature of PC on Dich-induced hepatotoxicity in male Wistar rats. Sixty-four male Wistar rats were grouped into eight including sham (normal saline), Dich (4 mg/kg/day), PC 1, 2, 3 (100, 150, 200 mg/kg/day, respectively) and Dich+PC 1, 2, 3 (100, 150, 200 mg/kg/day, respectively). All treatments were applied intraperitoneally (i.p) at 10 A.M. daily for 4 weeks. A day after the last treatment, the animals were sacrificed by cervical dislocation. The histopathological changes and apoptosis processes were assessed by light and fluorescent microscopy methods. The serum levels of hepatic enzymes, nitrite oxide (NO), and total antioxidant capacity (TAC) were evaluated. Dich significantly increased NO level, hepatic enzymes activity, apoptosis, mean diameter of hepatocytes (DH), and central hepatic vein diameter (CHVD) and also decreased TAC, mean weight of liver, and a total weight of rats compared to the sham group (P < 0.01). In all doses of PC and Dich+PC groups, a significant decrease was detected in values of apoptosis, hepatic enzymes activity, NO level, mean DH, and CHVD while an increase in TAC level, means of liver weight, and a total weight of rats was observed compared to the Dich group (P < 0.01). PC by antioxidant property can recover the catastrophic liver changes induced by Dich administration.
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23 June 2022
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s00580-022-03370-0
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We gratefully acknowledge the financial support of Kermanshah University of Medical Science (Grant no. 95594).
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Ethical approval was obtained from the ethics committee of the Kermanshah University of Medical Science (Ethics Certificate No. 95350). All information collected from this study was kept strictly confidential. All procedures performed in the study were in accordance with the ethical standards of the university research and ethics committee. Consent for participation was understood by completion and submission of the survey.
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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s00580-022-03370-0
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Salahshoor, M.R., Abdolmaleki, A., Jalili, C. et al. RETRACTED ARTICLE: Determination of histopathological and biomedical parameters in protective effects of Petroselinum crispum on hepatotoxicity induced by dichlorvos in male Wistar rats. Comp Clin Pathol 29, 501–509 (2020). https://doi.org/10.1007/s00580-019-03087-7
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DOI: https://doi.org/10.1007/s00580-019-03087-7