Abstract
The main objective of this study was to compare the common treatment methods of clinical endometritis (CE) including injection of PGF2a and intrauterine infusion of cephapirin benzathine (CB) with intrauterine infusion of 50% dextrose solution (DEX) and intrauterine infusion of liquid paraffin (LP) in dairy cows. To this end, 188 lactating Holstein cows with clinical signs of endometritis were randomly assigned into five treatment groups and cytological smear was prepared. In group 1 (n = 37), cows were treated with intrauterine infusion of CB. In the second group (n = 53), the treatment protocol included intramuscular injection of 500-mg cloprostenol sodium in cows with corpus luteum (CL) in their ovaries. In group 3 (n = 43), cows were treated with intrauterine infusion of DEX solution. In group 4 (n = 35), cows were treated with intrauterine infusion of LP solution and 20 untreated cows were assigned into a control group (group 5). Clinical treatment rates were 62.2, 66, 60.5, 54.3, and 50% in CB, PG, DEX, LP, and control groups, respectively (P ≥ 0.05). In the cytological assessment, there was no significant difference in reduction in the neutrophil’s number in the second examination after treatment (P ≥ 0.05). Percentage of cows with clean vaginal discharge in the second examination is higher in cows with CL than cows without CL in all five groups, but this difference was not significant (P ≥ 0.05). According to the result of this study, future large studies are required for assessment of DEX and LP as alternative therapies for the treatment of CE instead of antibiotics.
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Acknowledgements
The authors thank the Pegah Milk Company (Shiraz, Iran) for giving permission to use their herd in the experiment; we also thank their staff for the preparation of the cows involved in this study and their assistance during the project.
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Makki is responsible in all part of this project. Ahmadi is the general coordinator and designer of clinical part of this project. Gheisari analyzed the data. Nazifi is responsible of the cytological part.
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Makki, M., Ahmadi, M.R., Gheisari, H.R. et al. Cure rate of postpartum endometritis after different treatments in high produce dairy cows. Comp Clin Pathol 26, 921–928 (2017). https://doi.org/10.1007/s00580-017-2466-7
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DOI: https://doi.org/10.1007/s00580-017-2466-7